{"id":20641,"date":"2023-09-27T11:00:00","date_gmt":"2023-09-27T11:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/benin\/?p=20641"},"modified":"2023-09-25T20:31:36","modified_gmt":"2023-09-25T20:31:36","slug":"bpco-une-nouvelle-approche-pour-regenerer-des-poumons-endommages","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/benin\/toutes-les-actualites\/bpco-une-nouvelle-approche-pour-regenerer-des-poumons-endommages","title":{"rendered":"BPCO\u00a0: une nouvelle approche pour r\u00e9g\u00e9n\u00e9rer des poumons endommag\u00e9s"},"content":{"rendered":"

Africa-Press – Benin. <\/strong><\/span>Re\u0301ge\u0301ne\u0301rer les poumons. Voila un re\u0302ve de pneumologues et de patients dont les poumons sont tre\u0300s endommage\u0301s, comme dans la bronchopneumopathie chronique obstructive (BPCO), l\u2019emphyse\u0300me, une affection qui concerne 480 millions de patients dans le monde – 3,5 millions en France – et face a\u0300 laquelle aucun traitement curatif n\u2019existe.<\/p>\n

Re\u0301ge\u0301ne\u0301rer les poumons gra\u0302ce aux propres cellules souches des patients<\/b><\/p>\n

Ce re\u0302ve de re\u0301ge\u0301ne\u0301ration semble toutefois en bonne voie de concre\u0301tisation, si on en croit les tous premiers re\u0301sultats d\u2019un essai tout re\u0301cemment pre\u0301sente\u0301 au congre\u0300s international de la socie\u0301te\u0301 europe\u0301enne de pneumologie (European Respiratory Society) qui s’est de\u0301roule\u0301 a\u0300 Milan du 9 au 14 septembre 2023. En attente de publication mais pre\u0301sente\u0301s en confe\u0301rence de presse, ils reposent sur les travaux d\u2019une e\u0301quipe de pneumologues chinois de l’universite\u0301 Tongji (Shanghai) conduits avec le laboratoire Regend Therapeutics Ltd.<\/p>\n

Pour mener a\u0300 bien cette premie\u0300re re\u0301ge\u0301ne\u0301ration chez l\u2019humain des tissus pulmonaires abi\u0302me\u0301s, les chercheurs ont eu l\u2019ide\u0301e de recourir aux propres cellules souches des patients, les cellules proge\u0301nitrices P63+, de\u0301ja\u0300 connues lors de travaux mene\u0301s ante\u0301rieurement chez l\u2019animal, pour leur capacite\u0301 a\u0300 re\u0301parer le tissu le\u0301se\u0301 au niveau des alve\u0301oles, ces petits sacs ae\u0301riens au niveau desquels s\u2019effectuent les e\u0301changes gazeux lors de la respiration.<\/p>\n

Dans un premier temps, ils ont introduit dans les bronches un petit cathe\u0301ter contenant une brosse afin de collecter les cellules proge\u0301nitrices des voies respiratoires. Ces cellules ont e\u0301te\u0301 clone\u0301es pour qu\u2019elles se multiplient et ont e\u0301te\u0301 transplante\u0301es par bronchoscopie dans les poumons de 17 patients suivis ensuite durant 24 semaines afin d\u2019e\u0301valuer dans ce premier essai dit de phase 1 la tole\u0301rance de cette approche et son efficacite\u0301.<\/p>\n

\u00ab\u00a0La BPCO a de\u0301sespe\u0301re\u0301ment besoin de nouveaux traitement plus efficaces\u00a0\u00bb<\/b><\/p>\n

Selon l\u2019auteur principal, le professeur Wei Zuo qui a pre\u0301sente\u0301 les re\u0301sultats en confe\u0301rence de presse, la qualite\u0301 de vie des patients s\u2019est ame\u0301liore\u0301e apre\u0300s 12 semaines, la qualite\u0301 de l’e\u0301change d’air entre les poumons et la circulation sanguine e\u0301tant passe\u0301e de 30 % avant le traitement a\u0300 40 % ensuite. Autre parame\u0300tre mesure\u0301, la distance parcourue lors d\u2019un test de marche de 6 minutes, passe\u0301e de 410 me\u0300tres avant le traitement a\u0300 447 me\u0300tres a\u0300 24 semaines.<\/p>\n

Ce travail est certes tre\u0300s pre\u0301liminaire, mais il est prometteur. Et comme l\u2019a souligne\u0301 le Pr Omar Usmani, de l’Imperial Colle\u0300ge de Londres (Royaume-Uni), responsable de l’European Respiratory, \u00ab\u00a0ces re\u0301sultats sont encourageants, la BPCO a de\u0301sespe\u0301re\u0301ment besoin de nouveaux traitement plus efficaces\u00a0\u00bb.<\/p>\n

Un essai dit de phase 2, e\u0301valuant son efficacite\u0301 dans un groupe de patients plus important, doit de\u0301sormais de\u0301marrer. Il a de\u0301ja\u0300 e\u0301te\u0301 approuve\u0301 par la National Medical Products de Chine Administration (NMPA), l’e\u0301quivalent chinois de la Food and Drugs Administration (FDA) ame\u0301ricaine.<\/p>\n

Pour plus d’informations et d’analyses sur la Benin<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Benin. Re\u0301ge\u0301ne\u0301rer les poumons. Voila un re\u0302ve de pneumologues et de patients dont les poumons sont tre\u0300s endommage\u0301s, comme dans la bronchopneumopathie chronique obstructive (BPCO), l\u2019emphyse\u0300me, une affection qui concerne 480 millions de patients dans le monde – 3,5 millions en France – et face a\u0300 laquelle aucun traitement curatif n\u2019existe. Re\u0301ge\u0301ne\u0301rer les […]<\/p>\n","protected":false},"author":82,"featured_media":20640,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,50,45],"class_list":["post-20641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-benin","tag-benin"],"yoast_head":"\nBPCO\u00a0: une nouvelle approche pour r\u00e9g\u00e9n\u00e9rer des poumons endommag\u00e9s - B\u00e9nin<\/title>\n<meta name=\"description\" content=\"Re\u0301ge\u0301ne\u0301rer les poumons. 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