{"id":16006,"date":"2022-02-25T16:50:07","date_gmt":"2022-02-25T16:50:07","guid":{"rendered":"https:\/\/www.africa-press.net\/cameroun\/politique\/malaria-bloquer-une-proteine-permettrait-daffamer-le-parasite-responsable-du-paludisme"},"modified":"2022-02-25T18:28:23","modified_gmt":"2022-02-25T18:28:23","slug":"malaria-bloquer-une-proteine-permettrait-daffamer-le-parasite-responsable-du-paludisme","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/cameroun\/toutes-les-actualites\/malaria-bloquer-une-proteine-permettrait-daffamer-le-parasite-responsable-du-paludisme","title":{"rendered":"Malaria: Bloquer une prot\u00e9ine permettrait d\u2019affamer le parasite responsable du paludisme"},"content":{"rendered":"

Africa-Press – Cameroun. <\/strong><\/span>On pourrait un jour \u00eatre en mesure de litt\u00e9ralement faire mourir de faim le parasite responsable du paludisme en bloquant l’action d’une prot\u00e9ine. C’est ce qu’ont d\u00e9couvert des chercheurs internationaux dans le cadre d’un projet dirig\u00e9 par un scientifique qu\u00e9b\u00e9cois.<\/p>\n

Les chercheurs ont constat\u00e9 que la neutralisation de la prot\u00e9ine PfPX1 r\u00e9duit de plus de 75 % la croissance in vitro de Plasmodium falciparum, le protozoaire qui cause la forme la plus virulente du paludisme.<\/p>\n

On a montr\u00e9 dans nos travaux que cette prot\u00e9ine-l\u00e0 \u00e9tait super importante pour que le parasite puisse transporter l’h\u00e9moglobine jusque dans un organisme, la vacuole digestive, a expliqu\u00e9 Dave Richard, professeur \u00e0 la Facult\u00e9 de m\u00e9decine de l’Universit\u00e9 Laval et chercheur au Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval.<\/p>\n

C’est int\u00e9ressant parce que, pr\u00e9sentement, il n’y a pas d’agent contre [le paludisme] qui ciblerait justement l’\u00e9tape du transport de l’h\u00e9moglobine.<\/p>\n

Le parasite du paludisme est transmis aux humains par la piq\u00fbre d’un moustique. Une fois dans l’organisme, il se r\u00e9fugie dans les globules rouges, o\u00f9 il \u00e9chappe \u00e0 la d\u00e9tection du syst\u00e8me immunitaire et se nourrit de l’h\u00e9moglobine, la prot\u00e9ine qui transporte l’oxyg\u00e8ne vers les cellules du corps.<\/p>\n

Cependant, ce parasite a besoin de la prot\u00e9ine PfPX1 pour transf\u00e9rer l’h\u00e9moglobine vers l’\u00e9quivalent de son syst\u00e8me digestif, la vacuole digestive mentionn\u00e9e par M. Richard. Sans cette prot\u00e9ine, il est incapable de se nourrir. Et comme la prot\u00e9ine PfPX1 n’est pas pr\u00e9sente chez l’humain, on pourrait en bloquer l’action sans risquer de nuire au patient.<\/p>\n

On pourrait donc envisager la mise au point, dans quelques ann\u00e9es, d’un m\u00e9dicament qui emp\u00eacherait le parasite de se nourrir du sang de ses victimes, ce qui entra\u00eenerait sa mort.<\/p>\n

Le d\u00e9fi consistera maintenant \u00e0 trouver le financement n\u00e9cessaire \u00e0 la mise au point de cette th\u00e9rapie, ce qui n’est pas toujours simple quand on conna\u00eet le manque d’app\u00e9tit des grandes firmes pharmaceutiques pour la mise au point de m\u00e9dicaments qui s’adresseront principalement aux personnes plus pauvres de la plan\u00e8te.<\/p>\n

Souvent, dans notre domaine, \u00e7a va \u00eatre la Fondation Bill & Melinda Gates, a dit M. Richard. Ils donnent vraiment beaucoup d’argent justement pour la mise au point de m\u00e9dicaments et de vaccins contre des maladies davantage n\u00e9glig\u00e9es.<\/p>\n

Le paludisme a infect\u00e9 quelque 241 millions de personnes en 2020, faisant 627 000 morts. L’Organisation mondiale de la sant\u00e9 a approuv\u00e9 un premier vaccin contre la maladie l’an dernier, mais comme la pand\u00e9mie de coronavirus nous l’a brutalement rappel\u00e9, de nouvelles souches dangereuses peuvent toujours \u00e9merger.<\/p>\n

Des souches r\u00e9sistantes \u00e0 l’art\u00e9misinine, le principal antiparasitaire utilis\u00e9 contre le paludisme, ont d’ailleurs fait leur apparition en Asie du Sud-Est.<\/p>\n

En plus de l’Universit\u00e9 Laval, les chercheurs qui signent l’article paru dans la revue mBio sont rattach\u00e9s \u00e0 l’Universit\u00e9 Purdue, \u00e0 l’Universit\u00e9 de l’Alberta, au Centre de biologie de l’Acad\u00e9mie tch\u00e8que des sciences et \u00e0 l’Universit\u00e9 Notre-Dame.<\/p>\n

Pour plus d’informations et d’analyses sur la Cameroun<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Cameroun. On pourrait un jour \u00eatre en mesure de litt\u00e9ralement faire mourir de faim le parasite responsable du paludisme en bloquant l’action d’une prot\u00e9ine. C’est ce qu’ont d\u00e9couvert des chercheurs internationaux dans le cadre d’un projet dirig\u00e9 par un scientifique qu\u00e9b\u00e9cois. Les chercheurs ont constat\u00e9 que la neutralisation de la prot\u00e9ine PfPX1 r\u00e9duit […]<\/p>\n","protected":false},"author":82,"featured_media":16005,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21,11,10],"tags":[36,50,49],"class_list":["post-16006","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-communaute","category-homepage-french","category-toutes-les-actualites","tag-africa-press","tag-africa-press-cameroun","tag-cameroun"],"yoast_head":"\nMalaria: Bloquer une prot\u00e9ine permettrait d\u2019affamer le parasite responsable du paludisme - Cameroun<\/title>\n<meta name=\"description\" content=\"On pourrait un jour \u00eatre en mesure de litt\u00e9ralement faire mourir de faim le parasite responsable du paludisme en bloquan ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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