{"id":31968,"date":"2022-11-26T23:00:00","date_gmt":"2022-11-26T23:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/cameroun\/?p=31968"},"modified":"2022-11-22T21:16:23","modified_gmt":"2022-11-22T21:16:23","slug":"interview-notre-immunite-ne-depend-pas-seulement-de-notre-patrimoine-genetique","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/cameroun\/toutes-les-actualites\/interview-notre-immunite-ne-depend-pas-seulement-de-notre-patrimoine-genetique","title":{"rendered":"INTERVIEW. \u00ab\u00a0Notre immunit\u00e9 ne d\u00e9pend pas seulement de notre patrimoine g\u00e9n\u00e9tique\u00a0\u00bb"},"content":{"rendered":"

Africa-Press – Cameroun. <\/strong><\/span>Alain Fischer, est immunologue et de\u0301sormais connu du public pour son ro\u0302le de pre\u0301sident du Conseil d’orientation de la strate\u0301gie vaccinale.<\/p>\n

Sciences et Avenir : Notre corps a une capacite\u0301 extraordinaire a\u0300 se de\u0301fendre, a\u0300 se re\u0301parer lui-me\u0302me, notamment a\u0300 travers son syste\u0300me immunitaire. Mais finalement, qu’est-ce que le syste\u0300me immunitaire ?<\/p>\n

Alain Fischer : Une approche classique consiste a\u0300 dire qu’il s’agit d’un syste\u0300me de de\u0301fense contre des microorganismes e\u0301trangers. La re\u0301alite\u0301 est plus subtile ! Car ce syste\u0300me est a\u0300 l’e\u0301quilibre avec des virus, bacte\u0301ries, champignons pre\u0301sents sous notre peau, au niveau des muqueuses, notamment dans la gorge et dans l’intestin. Il serait donc plus juste de dire que l’immunite\u0301 est une triade : un syste\u0300me qui, a\u0300 la fois, nous e\u0301vite d’e\u0302tre contamine\u0301 par des microbes pathoge\u0300nes, mais aussi tole\u0300re des microbes utiles et, troisie\u0300mement, gra\u0302ce a\u0300 toutes sortes de me\u0301canismes de contro\u0302le, e\u0301vite des re\u0301ponses immunitaires inapproprie\u0301es contre nos propres constituants, ce qu’on appelle le soi.<\/p>\n

On parle d’immunite\u0301 inne\u0301e et d’immunite\u0301 acquise. Que signifient ces notions ?<\/p>\n

Ce sont les deux composantes de la re\u0301ponse immunitaire aux pathoge\u0300nes. La premie\u0300re est partage\u0301e par toutes nos cellules : elles posse\u0300dent, a\u0300 leur surface comme a\u0300 l’inte\u0301rieur, des capteurs qui les avertissent de la pre\u0301sence de mole\u0301cules venant de bacte\u0301ries, de virus ou de champignons, ou encore de signaux de danger. En quelques heures, notre organisme produit alors des substances capables soit d’avoir par elles-me\u0302mes un effet anti-infectieux comme les interfe\u0301rons, soit de recruter des cellules du syste\u0300me immunitaire, telles les cellules phagocytaires qui peuvent inge\u0301rer, et parfois dige\u0301rer, les microbes pathoge\u0300nes. La mise en jeu de cette re\u0301ponse inne\u0301e va induire en quelques jours la re\u0301ponse dite acquise ou adaptative, c’est-a\u0300-dire la production de lymphocytes T et de lymphocytes B. Dans certains contextes de\u0301finis par la re\u0301ponse inne\u0301e, les lymphocytes T vont s’orienter vers telle ou telle direction de re\u0301ponse, les lymphocytes B produire tels ou tels anticorps. Il y a en re\u0301alite\u0301 toute une se\u0301rie d’effecteurs d’immunite\u0301 dont l’organisation et l’orchestration de\u0301pendent du contexte.<\/p>\n

Comment cette construction fabuleuse, qui permet de contrer l’immense diversite\u0301 des pathoge\u0300nes, s’est-elle mise en place ?<\/p>\n

Tous les e\u0302tres vivants, des monocellulaires les plus simples aux plantes et mammife\u0300res les plus sophistique\u0301s, ont un syste\u0300me de de\u0301fense. Sans de\u0301fense immunitaire, pas de pre\u0301servation de l’espe\u0300ce ! Le fameux CRISPR lui-me\u0302me est un syste\u0300me de de\u0301fense des bacte\u0301ries contre les virus … Notre immunite\u0301 inne\u0301e, dont les bases sont partage\u0301es avec d’autres espe\u0300ces comme les insectes, date de plus de 750 millions d’anne\u0301es. L’immunite\u0301 adaptative, elle, est apparue a\u0300 peu pre\u0300s vers 500 millions d’anne\u0301es. C’est une forme d’adaptation permanente a\u0300 l’environnement.<\/p>\n

Pour plus d’informations et d’analyses sur la Cameroun<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Cameroun. Alain Fischer, est immunologue et de\u0301sormais connu du public pour son ro\u0302le de pre\u0301sident du Conseil d’orientation de la strate\u0301gie vaccinale. Sciences et Avenir : Notre corps a une capacite\u0301 extraordinaire a\u0300 se de\u0301fendre, a\u0300 se re\u0301parer lui-me\u0302me, notamment a\u0300 travers son syste\u0300me immunitaire. Mais finalement, qu’est-ce que le syste\u0300me immunitaire ? […]<\/p>\n","protected":false},"author":82,"featured_media":31967,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,50,49],"class_list":["post-31968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-cameroun","tag-cameroun"],"yoast_head":"\nINTERVIEW. 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