{"id":57122,"date":"2023-11-30T17:00:00","date_gmt":"2023-11-30T17:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/cameroun\/politique\/quatre-enfants-sourds-retrouvent-laudition-grace-a-la-therapie-genique"},"modified":"2023-12-01T23:04:38","modified_gmt":"2023-12-01T23:04:38","slug":"quatre-enfants-sourds-retrouvent-laudition-grace-a-la-therapie-genique","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/cameroun\/toutes-les-actualites\/quatre-enfants-sourds-retrouvent-laudition-grace-a-la-therapie-genique","title":{"rendered":"Quatre enfants sourds retrouvent l’audition gr\u00e2ce \u00e0 la th\u00e9rapie g\u00e9nique"},"content":{"rendered":"

Africa-Press – Cameroun. <\/strong><\/span>Les chercheurs ont injecte\u0301 dans l\u2019oreille interne des enfants un ge\u0300ne de secours pour remplacer celui de l\u2019otoferline, une prote\u0301ine indispensable au fonctionnement des cellules sensorielles de l\u2019audition, expliquent-ils dans le magazine ame\u0301ricain MIT Technology Review. \u00ab\u00a0Cette premie\u0300re correction ge\u0301ne\u0301tique d\u2019un sens humain est de bon augure pour la suite\u00a0\u00bb, commente Natalie Loundon qui dirige le service d\u2019audiophonologie pe\u0301diatrique a\u0300 l\u2019ho\u0302pital Necker \u2013 Enfants malades a\u0300 Paris.<\/p>\n

Une ope\u0301ration de\u0301licate, consistant a\u0300 injecter un vecteur viral dans l’oreille<\/p>\n

En effet, plusieurs autres essais cliniques du me\u0302me type sont en cours dans le monde, deux aux E\u0301tats-Unis et un en France. \u00ab\u00a0Nous commenc\u0327ons les premiers recrutements d\u2019enfants\u00a0\u00bb, pre\u0301cise Natalie Loundon qui agit pour le compte de la socie\u0301te\u0301 de biotechnologie Sensorion responsable de l\u2019essai clinique franc\u0327ais. La socie\u0301te\u0301 fabrique aussi le vecteur the\u0301rapeutique mis au point par les chercheurs de l\u2019Institut Pasteur qui travaillent maintenant dans le nouvel Institut national de l\u2019audition a\u0300 Paris.<\/p>\n

\u00ab\u00a0Nous be\u0301ne\u0301ficions de toute l\u2019expe\u0301rience scientifique de\u0301veloppe\u0301e a\u0300 l\u2019Institut Pasteur par la chercheuse Christine Petit et son e\u0301quipe depuis leur de\u0301couverte du ge\u0300ne de l\u2019otoferline en 1999\u00a0\u00bb, ajoute Natalie Loundon. La technique consiste a\u0300 injecter dans le liquide de l\u2019oreille interne un vecteur viral inoffensif de type AAV portant le ge\u0300ne fonctionnel de l\u2019otoferline et capable de cibler spe\u0301cifiquement les cellules cilie\u0301es internes responsables de l\u2019audition.<\/p>\n

Cette ope\u0301ration est de\u0301licate, car il faut acce\u0301der a\u0300 la cochle\u0301e en respectant les structures fines de l\u2019oreille interne afin d\u2019y injecter le vecteur dans le liquide qui baigne les cellules, mais elle est de\u0301ja\u0300 pratique\u0301e depuis des anne\u0301es en chirurgie de l\u2019oreille, notamment lors de la mise en place des implants cochle\u0301aires. Ces implants, qui permettent de re\u0301habiliter l\u2019audition dans les cas de surdite\u0301s profondes, comportent 12 a\u0300 22 e\u0301lectrodes pour stimuler directement le nerf auditif dans la cochle\u0301e.<\/p>\n

\u00ab\u00a0Ce premier succe\u0300s (…) ouvre la voie a\u0300 d\u2019autres approches visant des surdite\u0301s nettement plus fre\u0301quentes\u00a0\u00bb<\/p>\n

Dans la the\u0301rapie ge\u0301nique, il s\u2019agit de restaurer le fonctionnement normal de toute la structure avec ses 3500 cellules cilie\u0301es en y introduisant le ge\u0300ne de secours. \u00ab\u00a0Cette correction peut agir rapidement car nous savons que le de\u0301veloppement physiologique et anatomique de l\u2019oreille n\u2019est pas affecte\u0301 par la mutation du ge\u0300ne de l\u2019otoferline, celle-ci supprimant seulement la communication entre les cellules sensorielles du son et le nerf auditif\u00a0\u00bb, souligne la chercheuse.<\/p>\n

En 2018, cette the\u0301rapie ge\u0301nique avait de\u0301ja\u0300 montre\u0301 son efficacite\u0301 chez des souris porteuses de la mutation. Elle semble corriger de\u0301finitivement la surdite\u0301 car les cellules cilie\u0301es cochle\u0301aires ne se divisent plus une fois l\u2019oreille forme\u0301e in utero et elles pourraient donc exprimer le ge\u0300ne de secours durant toute la vie. La mutation du ge\u0300ne de l\u2019otoferline est tre\u0300s rare, mais le nombre d\u2019enfants concerne\u0301s reste sous-e\u0301value\u0301 car la surdite\u0301 qu\u2019elle entrai\u0302ne a\u0300 la naissance n\u2019est de\u0301piste\u0301e que par la mesure des potentiels e\u0301voque\u0301s auditifs, un test plus pre\u0301cis mais pas encore ge\u0301ne\u0301ralise\u0301 dans les maternite\u0301s en France.<\/p>\n

\u00ab\u00a0Ce premier succe\u0300s de the\u0301rapie ge\u0301nique d\u2019une surdite\u0301 conge\u0301nitale d\u2019origine ge\u0301ne\u0301tique ouvre ne\u0301anmoins la voie a\u0300 d\u2019autres approches visant des surdite\u0301s nettement plus fre\u0301quentes telles que celles dues aux mutations du ge\u0300ne GJB2\u00a0\u00bb, souligne aussi Natalie Loundon.<\/p>\n

Pour plus d’informations et d’analyses sur la Cameroun<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Cameroun. Les chercheurs ont injecte\u0301 dans l\u2019oreille interne des enfants un ge\u0300ne de secours pour remplacer celui de l\u2019otoferline, une prote\u0301ine indispensable au fonctionnement des cellules sensorielles de l\u2019audition, expliquent-ils dans le magazine ame\u0301ricain MIT Technology Review. \u00ab\u00a0Cette premie\u0300re correction ge\u0301ne\u0301tique d\u2019un sens humain est de bon augure pour la suite\u00a0\u00bb, commente Natalie […]<\/p>\n","protected":false},"author":82,"featured_media":57121,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,50,49],"class_list":["post-57122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-cameroun","tag-cameroun"],"yoast_head":"\nQuatre enfants sourds retrouvent l'audition gr\u00e2ce \u00e0 la th\u00e9rapie g\u00e9nique - 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