{"id":10175,"date":"2023-06-30T19:28:48","date_gmt":"2023-06-30T19:28:48","guid":{"rendered":"https:\/\/www.africa-press.net\/comores\/politique\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection"},"modified":"2023-06-30T21:44:45","modified_gmt":"2023-06-30T21:44:45","slug":"voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection","title":{"rendered":"Voici comment la cellule cause sa propre mort lors d\u2019une infection"},"content":{"rendered":"

Africa-Press – Comores. <\/strong><\/span>Lors d\u2019une infection, l\u2019organisme tout entier se met on ordre de bataille pour combattre l\u2019envahisseur et l\u2019empe\u0302cher de se multiplier et prendre le dessus. Tout ce qui compte est la survie de l\u2019ensemble, me\u0302me si cela implique de se sacrifier pour les autres. C\u2019est ce que peuvent faire les cellules qui ont e\u0301te\u0301 infecte\u0301es : se suicider avant que le pathoge\u0300ne ait le temps de se re\u0301pliquer et infecter les cellules autour. Un type de suicide cellulaire nomme\u0301 pyroptose, ou\u0300 tel un samourai\u0308 en de\u0301tresse, la cellule s\u2019e\u0301ventre pour causer sa propre mort et ainsi sauver ses proches. Une e\u0301tude des universite\u0301s suisses de Basel et Lausanne, publie\u0301e le 17 mai 2023 dans le journal Nature, vient de mettre en e\u0301vidence l\u2019outil qu\u2019elles utilisent pour faire ce hara-kiri cellulaire.<\/p>\n

Une mort cellulaire contro\u0302le\u0301e jusqu\u2019au dernier moment<\/b><\/p>\n

La pyroptose est cause\u0301e par l\u2019activation de l\u2019inflammasome, un complexe de prote\u0301ines qui se forme lorsque la cellule reconnai\u0302t des signaux inflammatoires, tels que des composants viraux ou bacte\u0301riens (comme leur mate\u0301riel ge\u0301ne\u0301tique ou leurs prote\u0301ines). Cela active une cascade inflammatoire qui aboutit par l\u2019e\u0301clatement de la cellule. Auparavant, les experts pensaient que cet e\u0301clatement e\u0301tait du\u0302 a\u0300 la pression osmotique : des pores dans la membrane permettraient le passage d\u2019eau de l\u2019exte\u0301rieur de la cellule vers son inte\u0301rieur, jusqu\u2019au point ou\u0300 la pression a\u0300 l\u2019inte\u0301rieur de la cellule serait tellement importante qu\u2019elle la faire exploser comme un ballon trop gonfle\u0301. Cette nouvelle recherche montre que la cellule en pyroptose n\u2019e\u0301clate pas mais ge\u0301ne\u0300re des entailles qui finissent par causer l\u2019ouverture de la membrane.<\/p>\n

Une file de prote\u0301ines qui se\u0301pare la membrane comme une plaie<\/b><\/p>\n

Le poignard que les cellules utilisent pour faire ces plaies est une prote\u0301ine nomme\u0301e Ninjurin 1, tre\u0300s bien conserve\u0301e lors de l\u2019e\u0301volution et pre\u0301sente chez une bonne partie des espe\u0300ces eucaryotes. C\u2019est une prote\u0301ine transmembranaire, c\u2019est-a\u0300-dire qu\u2019elle se localise dans la membrane cellulaire et la traverse, se terminant a\u0300 l\u2019exte\u0301rieur de la cellule. Dans cette e\u0301tude, les chercheurs montrent qu\u2019en temps normal, cette prote\u0301ine est isole\u0301e, tel un clou a\u0300 travers la membrane qui ne met pas en pe\u0301ril la solidite\u0301 de cette barrie\u0300re. Mais en changeant de conformation lors de la pyroptose, elle peut se joindre a\u0300 d\u2019autres copies d\u2019elle-me\u0302me et cre\u0301er ainsi des entailles sur la membrane.<\/p>\n

Ces Ninjurin 1 assemble\u0301es forment de longs filaments en se mettant en file, l\u2019une apre\u0300s l\u2019autre. Des filaments qui pouvaient atteindre quelques microme\u0300tres de long (sachant que la plupart des cellules font entre 10 et 100 microme\u0300tres de diame\u0300tre), se\u0301parant ainsi la membrane (comme une coupure de la peau) et causant la mort de la cellule.<\/p>\n

En observant cette prote\u0301ine sous microscope, les chercheurs ont remarque\u0301 que ces filaments peuvent e\u0302tre double\u0301s. C\u2019est-a\u0300-dire que cette file de prote\u0301ines peut e\u0302tre forme\u0301e par des couples, comme une file d\u2019enfants qui se tiennent par la main en bino\u0302me pour une sortie scolaire. Et qu\u2019ensuite elles peuvent se la\u0302cher, se\u0301parant les deux filaments comme une fermeture e\u0301clair qui s\u2019ouvre, ce qui faciliterait l\u2019e\u0301cartement de la membrane.<\/p>\n

Cette prote\u0301ine est essentielle pour ce type de mort cellulaire<\/b><\/p>\n

Les chercheurs ont confirme\u0301 cette fonction le\u0301tale pour la cellule en cre\u0301ant des versions mute\u0301es de Ninjurin 1 qui ne peuvent pas s\u2019assembler. Les cellules avec ces prote\u0301ines mute\u0301es n\u2019e\u0301clataient plus lors de la pyroptose, prouvant que c\u2019est bien Ninjurin 1 qui leur porte le coup de gra\u0302ce. Et que, sans elle, la cascade inflammatoire conse\u0301cutive a\u0300 une infection n\u2019aboutit pas au de\u0301ce\u0300s de la cellule infecte\u0301e.<\/p>\n

Cependant, les chercheurs ne savent pas encore comment cette cascade inflammatoire cause le changement de conformation de Ninjurin 1 et son assemblage en filaments. L\u2019arme que la cellule suicidaire utilise pour son hara-kiri a e\u0301te\u0301 trouve\u0301e, mais on ne sait pas encore quelle main porte le coup fatal.<\/p>\n

Pour plus d’informations et d’analyses sur la Comores<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Comores. Lors d\u2019une infection, l\u2019organisme tout entier se met on ordre de bataille pour combattre l\u2019envahisseur et l\u2019empe\u0302cher de se multiplier et prendre le dessus. Tout ce qui compte est la survie de l\u2019ensemble, me\u0302me si cela implique de se sacrifier pour les autres. C\u2019est ce que peuvent faire les cellules qui ont […]<\/p>\n","protected":false},"author":82,"featured_media":10174,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,53,45],"class_list":["post-10175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-comores","tag-comores"],"yoast_head":"\nVoici comment la cellule cause sa propre mort lors d\u2019une infection - Comores<\/title>\n<meta name=\"description\" content=\"Lors d\u2019une infection, l\u2019organisme tout entier se met on ordre de bataille pour combattre l\u2019envahisseur et l\u2019empe\u0302cher de ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Voici comment la cellule cause sa propre mort lors d\u2019une infection\" \/>\n<meta property=\"og:description\" content=\"Lors d\u2019une infection, l\u2019organisme tout entier se met on ordre de bataille pour combattre l\u2019envahisseur et l\u2019empe\u0302cher de ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\" \/>\n<meta property=\"og:site_name\" content=\"Comores\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-30T19:28:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-30T21:44:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/centrafricaine\/sites\/48\/2023\/06\/sm_1688144916.528392.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"899\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/comores\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Voici comment la cellule cause sa propre mort lors d\u2019une infection\",\"datePublished\":\"2023-06-30T19:28:48+00:00\",\"dateModified\":\"2023-06-30T21:44:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\"},\"wordCount\":766,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/centrafricaine\/sites\/48\/2023\/06\/sm_1688144916.528392.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Comores\",\"Comores\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\",\"url\":\"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/voici-comment-la-cellule-cause-sa-propre-mort-lors-dune-infection\",\"name\":\"Voici comment la cellule cause sa propre mort lors d\u2019une infection - 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