{"id":19022,"date":"2024-06-06T12:00:00","date_gmt":"2024-06-06T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/comores\/politique\/cancer-du-poumon-des-avancees-considerables-annoncees-lors-du-congres-international-a-chicago-asco-2"},"modified":"2024-06-07T04:33:27","modified_gmt":"2024-06-07T04:33:27","slug":"cancer-du-poumon-des-avancees-considerables-annoncees-lors-du-congres-international-a-chicago-asco-2","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/comores\/toutes-les-actualites\/cancer-du-poumon-des-avancees-considerables-annoncees-lors-du-congres-international-a-chicago-asco-2","title":{"rendered":"Cancer du poumon : des avanc\u00e9es consid\u00e9rables annonc\u00e9es lors du congr\u00e8s international \u00e0 Chicago (ASCO)"},"content":{"rendered":"

Africa-Press – Comores. <\/strong><\/span>2024, anne\u0301e du poumon pour la 60e e\u0301dition du congre\u0300s international du cancer (ASCO) qui re\u0301unit a\u0300 Chicago (Etats-Unis), comme chaque anne\u0301e, pre\u0300s de 35.000 spe\u0301cialistes. Cette anne\u0301e encore, des avance\u0301es notables face aux diffe\u0301rentes tumeurs pulmonaires ont e\u0301te\u0301 pre\u0301sente\u0301es (des tumeurs qui concernent chaque anne\u0301e en France 45.000 nouveaux patients et causent plus de 33.000 de\u0301ce\u0300s).<\/p>\n

Une nouvelle classe de me\u0301dicaments contre le cancer<\/b><\/p>\n

Entre associations d\u2019immunothe\u0301rapies a\u0300 des chimiothe\u0301rapies et recours aux conjugue\u0301s anticorps me\u0301dicaments (en anglais \u201cantibody drug conjugates\u201d, abre\u0301ge\u0301s ADC et aussi nomme\u0301s \u201canticorps arme\u0301s\u201d ou encore \u201cimmunoconjugue\u0301s\u201d), une nouvelle classe de me\u0301dicaments en plein de\u0301veloppement dans diffe\u0301rents cancers (sein, vessie…), des espoirs concrets se dessinent pour les malades.<\/p>\n

Pour me\u0301moire, il existe deux principales formes de cancers pulmonaires (bronchiques), de\u0301finies selon l\u2019origine des cellules des bronches dont ils sont issus.<\/p>\n

On distingue d\u2019une part les cancers bronchiques dits non a\u0300 petites cellules (CBNPC, les plus fre\u0301quents, 85 %, comprenant les ade\u0301nocarcinomes, les carcinomes e\u0301pidermoi\u0308des et les carcinomes a\u0300 grandes cellules) et d\u2019autre part les cancers bronchiques dits a\u0300 petites cellules (CBPC, 15%, principalement dus au tabac, tre\u0300s agressifs).<\/p>\n

Cette anne\u0301e encore, toutes ces formes voient leurs traitements e\u0301voluer et ce me\u0302me dans les formes de\u0301ja\u0300 me\u0301tastase\u0301es des CBNPC, et c\u2019est incontestablement une tre\u0300s bonne nouvelle. Exemple avec pas moins de deux e\u0301tudes importantes et pre\u0301sente\u0301es en se\u0301ance ple\u0301nie\u0300re, le temps fort du congre\u0300s.<\/p>\n

\u201cLe durvalumab devrait devenir un nouveau standard de traitement\u201d<\/b><\/p>\n

La premie\u0300re, ADRIATIC, vient (et c\u2019est une premie\u0300re) de de\u0301montrer l\u2019inte\u0301re\u0302t de l\u2019ajout pre\u0301coce d\u2019une immunothe\u0301rapie, le durvalumab (nom commercial Imfinzi, des laboratoires AstraZeneca) dans les formes localement avance\u0301es de CBPC.<\/p>\n

Une incontestable avance\u0301e la\u0300 ou\u0300 depuis trente ans, on administrait le me\u0302me traitement (chirurgie et chimiothe\u0301rapie), avec des re\u0301sultats de survie a\u0300 5 ans de 30%.<\/p>\n

Ce qui a permis au coordonnateur de l\u2019essai, le Dr David R. Spigel, directeur scientifique de l\u2019Institut Sarah Cannon (a\u0300 Nashville aux Etats-Unis) de de\u0301clarer que \u201cles re\u0301sultats d\u2019ADRIATIC repre\u0301sentent une perce\u0301e dans le CBPC et que le durvalumab devrait devenir un nouveau standard de traitement\u201d.<\/p>\n

Ce travail de phase 3 mene\u0301 aupre\u0300s d\u2019environ 500 personnes prouve qu\u2019apre\u0300s les traitements habituels (chimiothe\u0301rapie et radiothe\u0301rapie), l\u2019ajout de cette immunothe\u0301rapie, un anticorps PD-L1, re\u0301duit de 27% le risque de de\u0301ce\u0300s. De plus, 56% des patients sont encore en vie trois ans apre\u0300s leur diagnostic, contre 47% auparavant, soit une augmentation de la survie globale de pre\u0300s de 10%.<\/p>\n

L\u2019osimertinib ame\u0301liore la survie des patients<\/b><\/p>\n

La seconde e\u0301tude, LAURA, pre\u0301sente\u0301e a\u0300 l\u2019ASCO 2024 et simultane\u0301ment publie\u0301e dans le New England Journal of Medicine, concerne, elle, les CBNPC et plus particulie\u0300rement les tumeurs pre\u0301sentant un type particulier de mutation du re\u0301cepteur EGF dit de type EGFR, soit environ 10 % a\u0300 25 % des patients aux E\u0301tats-Unis et en Europe, 30 % a\u0300 40 % en Asie.<\/p>\n

Ici, c\u2019est l\u2019ajout non pas d\u2019une immunothe\u0301rapie mais d\u2019une the\u0301rapie cible\u0301e EGFR, l\u2019osimertinib (nom commercial Tagrisso, des laboratoires AstraZeneca), un inhibiteur de tyrosine kinase, qui confirme son inte\u0301re\u0302t, dans la survie globale des patients.<\/p>\n

Selon l\u2019e\u0301tude pre\u0301sente\u0301e a\u0300 Chicago, deux ans apre\u0300s le diagnostic, 65% des patients ayant rec\u0327u la the\u0301rapie cible\u0301e n\u2019ont en effet pas rechute\u0301, contre 12% des malades inclus dans le protocole standard.<\/p>\n

Ces deux avance\u0301es concernent environ 800 malades par an en France.<\/p>\n

L\u2019inte\u0301re\u0302t des \u201cmissiles biologiques\u201d<\/b><\/p>\n

Autre tendance e\u0301mergente, l\u2019arrive\u0301e d\u2019une nouvelle et tre\u0300s puissante arme dans le cancer, de ce que certains scientifiques qualifient de ve\u0301ritables \u201cmissiles biologiques\u201d.<\/p>\n

Le principe de ces conjugue\u0301s anticorps me\u0301dicaments, distincts de l\u2019immunothe\u0301rapie et de\u0301ja\u0300 utilise\u0301s dans certains cancers (sein, vessie…) par exemple, est le suivant: agir directement au niveau des cellules tumorales sans alte\u0301rer les cellules saines.<\/p>\n

Ils reposent sur la liaison d\u2019une mole\u0301cule de chimiothe\u0301rapie, via un syste\u0300me de lien appele\u0301 \u201clinker\u201d, a\u0300 un anticorps dirige\u0301 spe\u0301cifiquement contre une cible e\u0301ventuellement exprime\u0301e a\u0300 la surface des cellules tumorales.<\/p>\n

Certains d\u2019entre eux, ici les anti-TROP2, sont par exemple au c\u0153ur de l\u2019essai ICARUS-Lung01 mene\u0301 a\u0300 l\u2019Institut Gustave Roussy (Villejuif) face aux CBNPC.<\/p>\n

Dans cet essai mene\u0301 dans huit centres et pilote\u0301 par le Pr David Planchard et la Dr Barbara Pistilli, une centaine de patients atteints de cancers me\u0301tastase\u0301s en situation d\u2019impasse the\u0301rapeutique apre\u0300s trois lignes de traitement (chimiothe\u0301rapie et\/ou immunothe\u0301rapie ou the\u0301rapie cible\u0301e) ont rec\u0327u une perfusion de ces ADC.<\/p>\n

Et la\u0300 encore, un taux de re\u0301ponse prometteur de l\u2019ordre de 26 % a e\u0301te\u0301 mis en e\u0301vidence, permettant aux patients d\u2019atteindre une survie de plusieurs mois.<\/p>\n

Soulignons une autre avance\u0301e, toujours dans les CBNPC me\u0301tastase\u0301s, mais porteurs cette fois d\u2019une mutation d\u2019un autre type, KRAS G12C, pre\u0301sente chez environ 30% des patients. Il s\u2019agit d\u2019une the\u0301rapie cible\u0301e, l\u2019adragrasib (nom commercial Krazati, des laboratoires BMS) qui a de\u0301montre\u0301 son inte\u0301re\u0302t dans l\u2019e\u0301tude Krystal 12.<\/p>\n

Toutes ces avance\u0301es dans la lutte contre le cancer du poumon ne doivent pas faire oublier l\u2019urgence du de\u0301pistage et bien su\u0302r toujours le sevrage tabagique.<\/p>\n

Pour plus d’informations et d’analyses sur la Comores<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Comores. 2024, anne\u0301e du poumon pour la 60e e\u0301dition du congre\u0300s international du cancer (ASCO) qui re\u0301unit a\u0300 Chicago (Etats-Unis), comme chaque anne\u0301e, pre\u0300s de 35.000 spe\u0301cialistes. Cette anne\u0301e encore, des avance\u0301es notables face aux diffe\u0301rentes tumeurs pulmonaires ont e\u0301te\u0301 pre\u0301sente\u0301es (des tumeurs qui concernent chaque anne\u0301e en France 45.000 nouveaux patients et […]<\/p>\n","protected":false},"author":82,"featured_media":19021,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,53,45],"class_list":["post-19022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-comores","tag-comores"],"yoast_head":"\nCancer du poumon : des avanc\u00e9es consid\u00e9rables annonc\u00e9es lors du congr\u00e8s international \u00e0 Chicago (ASCO) - Comores<\/title>\n<meta name=\"description\" content=\"2024, anne\u0301e du poumon pour la 60e e\u0301dition du congre\u0300s international du cancer (ASCO) qui re\u0301unit 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