{"id":11603,"date":"2022-11-28T12:00:00","date_gmt":"2022-11-28T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/congo-brazzaville\/?p=11603"},"modified":"2022-11-22T21:27:22","modified_gmt":"2022-11-22T21:27:22","slug":"le-covid-19-pourrait-accelerer-le-developpement-de-la-maladie-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/congo-brazzaville\/toutes-les-actualites\/le-covid-19-pourrait-accelerer-le-developpement-de-la-maladie-de-parkinson","title":{"rendered":"Le Covid-19 pourrait acc\u00e9l\u00e9rer le d\u00e9veloppement de la maladie de Parkinson"},"content":{"rendered":"

Africa-Press – Congo Brazzaville. <\/strong><\/span>De l\u2019huile sur le feu des maladies neurode\u0301ge\u0301ne\u0301ratives ? Le Covid affecte un grand nombre d\u2019organes, dont le cerveau. Les proble\u0300mes neurologiques sont d\u2019ailleurs tre\u0300s fre\u0301quents parmi les personnes souffrant d’un Covid long. Plusieurs e\u0301tudes ont montre\u0301 que l\u2019infection au coronavirus cause de l\u2019inflammation dans le cerveau, suivie d\u2019une mortalite\u0301 neuronale accrue. Cette inflammation est de\u0301clenche\u0301e principalement par des micro-he\u0301morragies qui asphyxient les cellules ce\u0301re\u0301brales, mais le virus lui-me\u0302me pourrait participer directement a\u0300 cette inflammation. Des chercheurs australiens de l\u2019Universite\u0301 de Queensland ont montre\u0301 que le SARS-CoV-2 active des cellules immunitaires du cerveau et cause ainsi un e\u0301tat inflammatoire. Ce processus serait amplifie\u0301 chez des personnes atteintes par la maladie de Parkinson, ce qui pourrait acce\u0301le\u0301rer le de\u0301veloppement de cette maladie neurode\u0301ge\u0301ne\u0301rative. Leur de\u0301couverte a e\u0301te\u0301 publie\u0301e le 1er novembre 2022 dans le journal Molecular Psychiatry.<\/p>\n

Le coronavirus active un processus inflammatoire dans le cerveau<\/b><\/p>\n

Des analyses des cerveaux de personnes de\u0301ce\u0301de\u0301es a\u0300 cause du Covid avaient de\u0301ja\u0300 mis en e\u0301vidence une inflammation du tissu ce\u0301re\u0301bral ainsi qu\u2019une suractivation de cellules microgliales. Ces cellules sont des macrophages qui s\u2019activent lorsque la re\u0301ponse immunitaire inne\u0301e est de\u0301clenche\u0301e, ce qui arrive notamment lors d\u2019une infection. Une fois active\u0301es, les cellules microgliales produisent une prote\u0301ine (NLRP3). Cette prote\u0301ine forme l\u2019inflammasome, mole\u0301cule qui provoque une cascade inflammatoire qui finit par entrainer la mort cellulaire des cellules infecte\u0301es. Mais si cette activation se poursuit dans le temps, elle peut ge\u0301ne\u0301rer une inflammation chronique.<\/p>\n

Les chercheurs ont e\u0301tudie\u0301 l\u2019activation de ces cellules microgliales chez des souris exprimant le re\u0301cepteur humain ACE2, utilise\u0301 par le coronavirus pour pe\u0301ne\u0301trer les cellules. Apre\u0300s l\u2019infection, une suractivation de ces cellules immunitaires a e\u0301te\u0301 observe\u0301e dans le cerveau ainsi qu\u2019une production accrue de NLRP3. Des e\u0301tudes in vitro ont ensuite montre\u0301 que le coronavirus parvient a\u0300 infecter ces macrophages, mais n\u2019arrive pas a\u0300 se re\u0301pliquer dans ces cellules. Les cellules microgliales seraient donc active\u0301es directement par le virus, de\u0301tectant sa pre\u0301sence gra\u0302ce a\u0300 l\u2019infection. Et puisque le virus ne peut pas s\u2019y re\u0301pliquer, ces cellules ne seraient pas en danger.<\/p>\n

L\u2019inflammation neurologique est empire\u0301e par l\u2019\u03b1-synucle\u0301ine<\/b><\/p>\n

Le coronavirus de\u0301clenche donc directement la production de l\u2019inflammasome et l\u2019e\u0301tat inflammatoire qui s’ensuit et qui est similaire a\u0300 celui observe\u0301 dans certaines maladies neurode\u0301ge\u0301ne\u0301ratives. \u00ab\u00a0Cela pourrait expliquer pourquoi les personnes qui ont eu le Covid sont plus susceptibles de de\u0301velopper des sympto\u0302mes proches de ceux de la maladie de Parkinson\u00a0\u00bb, affirme Eduardo Albornoz Balmaceda, auteur de l\u2019e\u0301tude, dans un communique\u0301.<\/p>\n

Pire : ce processus inflammatoire est amplifie\u0301 lorsque l\u2019infection survient en pre\u0301sence d\u2019\u03b1-synucle\u0301ine, prote\u0301ine qui s\u2019accumule dans la maladie de Parkinson. \u00ab\u00a0Pour quelqu\u2019un de pre\u0301dispose\u0301 pour cette pathologie (et qui a donc de\u0301ja\u0300 une accumulation d\u2019\u03b1-synucle\u0301ine, ndlr), avoir le Covid-19 pourrait e\u0302tre comme jeter de l\u2019huile sur le feu qui menace son cerveau, ajoute Trent Woodruff, directeur de la recherche. La me\u0302me chose pourrait s\u2019appliquer aux pre\u0301dispositions a\u0300 la maladie d\u2019Alzheimer ou autres pathologies lie\u0301es a\u0300 ces inflammasomes.\u00a0\u00bb<\/p>\n

Pour plus d’informations et d’analyses sur la Congo Brazzaville<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Congo Brazzaville. De l\u2019huile sur le feu des maladies neurode\u0301ge\u0301ne\u0301ratives ? Le Covid affecte un grand nombre d\u2019organes, dont le cerveau. Les proble\u0300mes neurologiques sont d\u2019ailleurs tre\u0300s fre\u0301quents parmi les personnes souffrant d’un Covid long. Plusieurs e\u0301tudes ont montre\u0301 que l\u2019infection au coronavirus cause de l\u2019inflammation dans le cerveau, suivie d\u2019une mortalite\u0301 neuronale […]<\/p>\n","protected":false},"author":82,"featured_media":11602,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,47,46],"class_list":["post-11603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-congo-brazzaville","tag-congo-brazzaville"],"yoast_head":"\nLe Covid-19 pourrait acc\u00e9l\u00e9rer le d\u00e9veloppement de la maladie de Parkinson - Congo Brazzaville<\/title>\n<meta name=\"description\" content=\"De l\u2019huile sur le feu des maladies neurode\u0301ge\u0301ne\u0301ratives ? 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