{"id":112427,"date":"2026-02-07T15:16:49","date_gmt":"2026-02-07T15:16:49","guid":{"rendered":"https:\/\/www.africa-press.net\/cotedivoire\/politique\/avancees-de-lia-dans-linterpretation-du-genome"},"modified":"2026-02-07T15:27:43","modified_gmt":"2026-02-07T15:27:43","slug":"avancees-de-lia-dans-linterpretation-du-genome","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome","title":{"rendered":"Avanc\u00e9es de l’IA dans l’interpr\u00e9tation du g\u00e9nome"},"content":{"rendered":"

Africa-Press – C\u00f4te d’Ivoire. <\/strong><\/span>AlphaGenome, outil d’intelligence artificielle (IA) de Google rendu public mercredi, fait un pas de plus dans la compre\u0301hension du ge\u0301nome, en analysant comment des portions de l’ADN re\u0301gulent l’activite\u0301 des ge\u0300nes dans la cellule.<\/p>\n

Le de\u0301chiffrage de l’ensemble du ge\u0301nome humain en 2003, \u00ab\u00a0nous a donne\u0301 le livre de la vie, mais le lire reste un de\u0301fi\u00a0\u00bb, a rappele\u0301 Pushmeet Kohli, vice-pre\u0301sident de la recherche chez Google DeepMind, a\u0300 l’occasion de la pre\u0301sentation d’AlphaGenome dans la revue Nature.<\/p>\n

\u00ab\u00a0Nous avons le texte\u00a0\u00bb – la succession de 3 milliards de paires de nucle\u0301otides A, T, C et G qui composent l’ADN -, mais \u00ab\u00a0comprendre la grammaire (…) et la manie\u0300re dont cela gouverne la vie constitue la prochaine frontie\u0300re majeure de la recherche\u00a0\u00bb, a-t-il souligne\u0301 devant la presse.<\/p>\n

Seules 2% des se\u0301quences d’ADN \u00ab\u00a0codent\u00a0\u00bb directement des prote\u0301ines, indispensables au fonctionnement des organismes vivants.<\/p>\n

Les 98% restants ont un ro\u0302le de \u00ab\u00a0chef d’orchestre\u00a0\u00bb: elles coordonnent, prote\u0300gent et re\u0301gulent l’expression de l’information ge\u0301ne\u0301tique dans chacune de nos cellules. Ces se\u0301quences, appele\u0301es \u00ab\u00a0non codantes\u00a0\u00bb, contiennent de nombreux variants associe\u0301s a\u0300 des maladies.<\/p>\n

Ce sont elles qu’e\u0301tudie AlphaGenome, venant comple\u0301ter les autres mode\u0300les de\u0301veloppe\u0301s par le laboratoire d’IA de Google: AlphaMissense (analyse des se\u0301quences codantes de l’ADN), AlphaProteo (conception de prote\u0301ines) et AlphaFold (pre\u0301diction de la structure de prote\u0301ines, prix Nobel de chimie en 2024).<\/p>\n

Le mode\u0300le d’apprentissage profond (dans lequel un re\u0301seau de neurones apprend a\u0300 reconnai\u0302tre automatiquement des motifs complexes) a e\u0301te\u0301 entrai\u0302ne\u0301 avec des donne\u0301es provenant de grands consortiums publics, qui ont mesure\u0301 expe\u0301rimentalement ces proprie\u0301te\u0301s dans des centaines de types de cellules et de tissus chez l’homme et la souris.<\/p>\n

Il est capable d’analyser une longue se\u0301quence d’ADN et de \u00ab\u00a0pre\u0301dire\u00a0\u00bb l’influence de chaque paire de nucle\u0301otides sur diffe\u0301rents processus biologiques dans la cellule: activer ou re\u0301primer l’expression d’un ge\u0300ne, piloter l’assemblage de l’ARN (une \u00ab\u00a0copie\u00a0\u00bb de l’ADN qui transmet l’information ge\u0301ne\u0301tique dans la cellule)…<\/p>\n

– \u00ab\u00a0Fondamental\u00a0\u00bb mais \u00ab\u00a0pas parfait\u00a0\u00bb –<\/p>\n

D’autres mode\u0300les existaient de\u0301ja\u0300. Mais ils devaient faire un compromis entre la longueur des se\u0301quences analyse\u0301es et la finesse de la re\u0301solution.<\/p>\n

Or, une longue se\u0301quence – jusqu’a\u0300 un million de paires de nucle\u0301otides – est \u00ab\u00a0ne\u0301cessaire pour comprendre l’environnement re\u0301gulateur complet d’un ge\u0300ne unique\u00a0\u00bb, explique Ziga Avsec, un des co-auteurs du projet.<\/p>\n

Et la finesse de la re\u0301solution permet d’e\u0301tudier l’effet de variants ge\u0301ne\u0301tiques en comparant les pre\u0301dictions de se\u0301quences mute\u0301es a\u0300 celles de se\u0301quences non mute\u0301es.<\/p>\n

Autre avance\u0301e, AlphaGenome mode\u0301lise simultane\u0301ment l’influence de la se\u0301quence sur onze processus biologiques, alors que les scientifiques devaient jusqu’a\u0300 pre\u0301sent utiliser plusieurs mode\u0300les.<\/p>\n

Cet outil \u00ab\u00a0peut acce\u0301le\u0301rer notre compre\u0301hension du ge\u0301nome en aidant a\u0300 cartographier l’emplacement des e\u0301le\u0301ments fonctionnels et a\u0300 de\u0301terminer leurs ro\u0302les au niveau mole\u0301culaire\u00a0\u00bb, estime Natasha Latysheva, e\u0301galement co-autrice.<\/p>\n

\u00ab\u00a0Nous espe\u0301rons que les chercheurs enrichiront avec davantage de donne\u0301es et de modalite\u0301s\u00a0\u00bb le mode\u0300le, de\u0301ja\u0300 teste\u0301 par 3.000 scientifiques de 160 pays et de\u0301sormais disponible en open source pour la recherche non-commerciale, souligne M. Kohli.<\/p>\n

\u00ab\u00a0Identifier pre\u0301cise\u0301ment les diffe\u0301rences dans nos ge\u0301nomes qui nous rendent plus ou moins susceptibles de de\u0301velopper des milliers de maladies est une e\u0301tape cle\u0301 vers de meilleurs traitements\u00a0\u00bb, note Ben Lehner, responsable de la ge\u0301nomique ge\u0301ne\u0301rative et synthe\u0301tique au Wellcome Sanger Institute de Cambridge.<\/p>\n

Le chercheur, qui n’a pas participe\u0301 au projet mais a teste\u0301 le mode\u0300le, le juge \u00ab\u00a0tre\u0300s performant\u00a0\u00bb, mais encore \u00ab\u00a0loin d’e\u0302tre parfait\u00a0\u00bb.<\/p>\n

\u00ab\u00a0Les mode\u0300les d’IA ne sont bons que dans la mesure ou\u0300 les donne\u0301es utilise\u0301es pour les entrai\u0302ner le sont\u00a0\u00bb, or la plupart des jeux de donne\u0301es existants \u00ab\u00a0sont trop petits et insuffisamment standardise\u0301s\u00a0\u00bb, explique-t-il dans une re\u0301action a\u0300 l’organisme britannique Science Media Center (SMC).<\/p>\n

AlphaGenome n’est pas une \u00ab\u00a0solution miracle a\u0300 toutes les questions biologiques\u00a0\u00bb, l’expression des ge\u0300nes \u00ab\u00a0e\u0301tant influence\u0301e par des facteurs environnementaux complexes\u00a0\u00bb, mais il constitue un \u00ab\u00a0outil fondamental\u00a0\u00bb, abonde Robert Goldstone, responsable de la ge\u0301nomique au Francis Crick Institute, cite\u0301 dans le me\u0302me texte.<\/p>\n

Selon lui, ce nouvel outil permettra aux scientifiques \u00ab\u00a0d’e\u0301tudier et de simuler de manie\u0300re programmatique les bases ge\u0301ne\u0301tiques des maladies complexes\u00a0\u00bb.<\/p>\n

Pour plus d’informations et d’analyses sur la C\u00f4te d’Ivoire<\/span>, suivez Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – C\u00f4te d’Ivoire. AlphaGenome, outil d’intelligence artificielle (IA) de Google rendu public mercredi, fait un pas de plus dans la compre\u0301hension du ge\u0301nome, en analysant comment des portions de l’ADN re\u0301gulent l’activite\u0301 des ge\u0300nes dans la cellule. Le de\u0301chiffrage de l’ensemble du ge\u0301nome humain en 2003, \u00ab\u00a0nous a donne\u0301 le livre de la vie, […]<\/p>\n","protected":false},"author":82,"featured_media":112426,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[29],"class_list":["post-112427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-cote-divoire"],"yoast_head":"\nAvanc\u00e9es de l'IA dans l'interpr\u00e9tation du g\u00e9nome - C\u00f4te d'Ivoire<\/title>\n<meta name=\"description\" content=\"AlphaGenome, outil d'intelligence artificielle (IA) de Google rendu public mercredi, fait un pas de plus dans la compre\u0301 ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avanc\u00e9es de l'IA dans l'interpr\u00e9tation du g\u00e9nome\" \/>\n<meta property=\"og:description\" content=\"AlphaGenome, outil d'intelligence artificielle (IA) de Google rendu public mercredi, fait un pas de plus dans la compre\u0301 ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\" \/>\n<meta property=\"og:site_name\" content=\"C\u00f4te d'Ivoire\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-07T15:16:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-07T15:27:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/cote\/sites\/43\/2026\/02\/sm_1770465432.523752.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Avanc\u00e9es de l’IA dans l’interpr\u00e9tation du g\u00e9nome\",\"datePublished\":\"2026-02-07T15:16:49+00:00\",\"dateModified\":\"2026-02-07T15:27:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\"},\"wordCount\":844,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/cote\/sites\/43\/2026\/02\/sm_1770465432.523752.jpg\",\"keywords\":[\"C\u00d4TE D'IVOIRE\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\",\"url\":\"https:\/\/www.africa-press.net\/cotedivoire\/toutes-les-actualites\/avancees-de-lia-dans-linterpretation-du-genome\",\"name\":\"Avanc\u00e9es de l'IA dans l'interpr\u00e9tation du g\u00e9nome - 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