{"id":10738,"date":"2023-03-25T16:15:46","date_gmt":"2023-03-25T16:15:46","guid":{"rendered":"https:\/\/www.africa-press.net\/djibouti\/politique\/comment-les-drogues-psychedeliques-remodelent-le-cerveau"},"modified":"2023-03-25T16:27:36","modified_gmt":"2023-03-25T16:27:36","slug":"comment-les-drogues-psychedeliques-remodelent-le-cerveau","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau","title":{"rendered":"Comment les drogues psych\u00e9d\u00e9liques remod\u00e8lent le cerveau"},"content":{"rendered":"

Africa-Press – Djibouti. <\/strong><\/span>Le me\u0301canisme par lequel les mole\u0301cules dites \u00ab\u00a0psyche\u0301de\u0301liques\u00a0\u00bb remode\u0300lent les connexions neuronales dans le cerveau vient d’e\u0302tre e\u0301lucide\u0301. Une perce\u0301e scientifique potentiellement importante, alors que la recherche en psychiatrie autour de ces mole\u0301cules est plus dynamique que jamais. Connues pour provoquer de puissantes hallucinations sensorielles, les drogues illicites comme le LSD, la DMT ou la psilocybine des champignons hallucinoge\u0300nes ont montre\u0301, lors d’essais cliniques, des re\u0301sultats e\u0301tonnants sur des cas de de\u0301pression re\u0301sistante aux traitements ou de troubles du stress post-traumatique. Durant son \u00ab\u00a0trip\u00a0\u00bb, plus ou moins dose\u0301, le patient est accompagne\u0301 par son psychiatre, qui profite de l’e\u0301tat de conscience modifie\u0301 pour une se\u0301ance de remodelage ce\u0301re\u0301bral. En France, depuis son autorisation fin 2020, la ke\u0301tamine est par exemple entre\u0301e dans l’arsenal the\u0301rapeutique courant contre les formes re\u0301sistantes aux antide\u0301presseurs.<\/p>\n

Les drogues psyche\u0301de\u0301liques agissent a\u0300 l’inte\u0301rieur des neurones<\/b><\/p>\n

Mais si, par empirisme, les psyche\u0301de\u0301liques se portent a\u0300 nouveau au chevet des troubles mentaux, on ne savait pas comment ces mole\u0301cules induisent cette fene\u0302tre de plasticite\u0301 ce\u0301re\u0301brale, permettant a\u0300 la psychothe\u0301rapie de voir ses effets ainsi transforme\u0301s sur les cas les plus se\u0301ve\u0300res. La plasticite\u0301 ce\u0301re\u0301brale est la capacite\u0301 e\u0301prouve\u0301e du cerveau a\u0300 re\u0301arranger ses re\u0301seaux de neurones, en faire croi\u0302tre de nouveaux et remodeler les connexions. L’e\u0301tude publie\u0301e dans la revue Science par une e\u0301quipe de l\u2019universite\u0301 de Californie a\u0300 Davis (Etats-Unis) montre, a\u0300 partir de tests sur des neurones in vitro, que les psyche\u0301de\u0301liques ont une fac\u0327on tre\u0300s particulie\u0300re de cibler le re\u0301cepteur de la se\u0301rotonine 2A (5-TH2AR) dans le cerveau.<\/p>\n

Au contraire d’autres mole\u0301cules ciblant le me\u0302me re\u0301cepteur mais n’induisant pas de neuroplasticite\u0301, la chimie de ces drogues leur permet de traverser la membrane cellulaire pour agir a\u0300 l’inte\u0301rieur des neurones. Or, les re\u0301cepteurs 5-TH2AR sont plus concentre\u0301s a\u0300 l’inte\u0301rieur qu\u2019en surface. Les expe\u0301riences mene\u0301es ont permis d’observer que la capacite\u0301 a\u0300 promouvoir la plasticite\u0301 neuronale d’une mole\u0301cule ciblant les re\u0301cepteurs 5-TH2A e\u0301tait corre\u0301le\u0301e a\u0300 son aptitude a\u0300 traverser la membrane des neurones. Ce qui sugge\u0300re que selon qu’ils se trouvent en surface ou a\u0300 l’inte\u0301rieur, ces re\u0301cepteurs n’activent pas les me\u0302mes voies de signalisation dans le cerveau.<\/p>\n

Des re\u0301cepteurs de la se\u0301rotonine 2A (5-HT2A) apparaissent en couleurs a\u0300 l’inte\u0301rieur d’un neurone (en blanc). Cre\u0301dits : DAVID OLSON\/UC DAVIS<\/p>\n

De\u0301velopper des the\u0301rapies cible\u0301es<\/b><\/p>\n

\u00ab\u00a0Les inhibiteurs se\u0301lectifs de la recapture de la se\u0301rotonine comme le Prozac ou le Paxil ge\u0301ne\u0301ralement prescrits contre la de\u0301pression pour augmenter les niveaux de se\u0301rotonine favorisent certes une certaine \u00ab\u00a0repousse des neurones\u00a0\u00bb, mais ils n’agissent que tre\u0300s, tre\u0300s lentement\u00a0\u00bb, pre\u0301cise David Olson qui a dirige\u0301 ces travaux. Les psyche\u0301de\u0301liques ont au contraire un effet imme\u0301diat majeur qui a pousse\u0301 David Oldon a\u0300 forger le terme de \u00ab\u00a0psychoplastoge\u0300nes\u00a0\u00bb pour de\u0301signer ces mole\u0301cules. \u00ab\u00a0Le but de notre e\u0301tude e\u0301tait de re\u0301soudre l’e\u0301nigme des effets singuliers de ces drogues\u00a0\u00bb, pre\u0301cise le chercheur. Car \u00ab\u00a0une fois que les me\u0301canismes sous-jacents des be\u0301ne\u0301fices observe\u0301s seront connus, nous pourrons peut-e\u0302tre de\u0301velopper des the\u0301rapies plus cible\u0301es\u00a0\u00bb, ajoute-t-il. La cible, c’est donc ce re\u0301cepteur intracellulaire de la plasticite\u0301 ce\u0301re\u0301brale a\u0300 partir duquel pourraient e\u0302tre mises au point des mole\u0301cules plus pre\u0301cises, de\u0301barrasse\u0301es du statut de stupe\u0301fiant qui ralentit aujourd’hui la recherche clinique.<\/p>\n

Pour plus d’informations et d’analyses sur la Djibouti<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Djibouti. Le me\u0301canisme par lequel les mole\u0301cules dites \u00ab\u00a0psyche\u0301de\u0301liques\u00a0\u00bb remode\u0300lent les connexions neuronales dans le cerveau vient d’e\u0302tre e\u0301lucide\u0301. Une perce\u0301e scientifique potentiellement importante, alors que la recherche en psychiatrie autour de ces mole\u0301cules est plus dynamique que jamais. Connues pour provoquer de puissantes hallucinations sensorielles, les drogues illicites comme le LSD, la […]<\/p>\n","protected":false},"author":82,"featured_media":10737,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,49,50],"class_list":["post-10738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-djibouti","tag-djibouti"],"yoast_head":"\nComment les drogues psych\u00e9d\u00e9liques remod\u00e8lent le cerveau - Djibouti<\/title>\n<meta name=\"description\" content=\"Le me\u0301canisme par lequel les mole\u0301cules dites "psyche\u0301de\u0301liques" remode\u0300lent les connexions neuronales dans le cerveau v ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comment les drogues psych\u00e9d\u00e9liques remod\u00e8lent le cerveau\" \/>\n<meta property=\"og:description\" content=\"Le me\u0301canisme par lequel les mole\u0301cules dites "psyche\u0301de\u0301liques" remode\u0300lent les connexions neuronales dans le cerveau v ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\" \/>\n<meta property=\"og:site_name\" content=\"Djibouti\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-25T16:15:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-25T16:27:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/djibouti\/sites\/52\/2023\/03\/postQueueImg_1679744774.49.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Comment les drogues psych\u00e9d\u00e9liques remod\u00e8lent le cerveau\",\"datePublished\":\"2023-03-25T16:15:46+00:00\",\"dateModified\":\"2023-03-25T16:27:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\"},\"wordCount\":687,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/djibouti\/sites\/52\/2023\/03\/postQueueImg_1679744774.49.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Djibouti\",\"Djibouti\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\",\"url\":\"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/comment-les-drogues-psychedeliques-remodelent-le-cerveau\",\"name\":\"Comment les drogues psych\u00e9d\u00e9liques remod\u00e8lent le cerveau - 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