{"id":12591,"date":"2023-05-16T13:21:28","date_gmt":"2023-05-16T13:21:28","guid":{"rendered":"https:\/\/www.africa-press.net\/djibouti\/politique\/un-medicament-oral-destine-a-eliminer-une-contamination-radioactive-teste-chez-lhumain"},"modified":"2023-05-16T14:31:46","modified_gmt":"2023-05-16T14:31:46","slug":"un-medicament-oral-destine-a-eliminer-une-contamination-radioactive-teste-chez-lhumain","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/djibouti\/toutes-les-actualites\/un-medicament-oral-destine-a-eliminer-une-contamination-radioactive-teste-chez-lhumain","title":{"rendered":"Un m\u00e9dicament oral destin\u00e9 \u00e0 \u00e9liminer une contamination radioactive test\u00e9 chez l’humain"},"content":{"rendered":"

Africa-Press – Djibouti. <\/strong><\/span>La guerre en Ukraine fait planer depuis plusieurs mois un risque nucle\u0301aire, d’abord avec la menace d’une attaque atomique, et tre\u0300s re\u0301cemment, avec la situation critique a\u0300 la centrale nucle\u0301aire de Zaporijjia. Hasard du calendrier, les National Institutes of Health (NIH) – agences nationales ame\u0301ricaines de recherche me\u0301dicale – ont annonce\u0301, le 15 mai 2023, le de\u0301but d’un essai chez l’humain d’un me\u0301dicament destine\u0301 a\u0300 e\u0301liminer une contamination radioactive.<\/p>\n

Jusqu’a\u0300 7,5 grammes pour la dose la plus forte<\/b><\/p>\n

Sa simple e\u0301vocation est lourde de profondes craintes : la contamination radioactive interne survient lorsque des e\u0301le\u0301ments radioactifs sont absorbe\u0301s a\u0300 travers une peau blesse\u0301e, lorsqu’ils sont inhale\u0301s ou inge\u0301re\u0301s, apre\u0300s l’explosion d’une bombe sale ou un accident dans une centrale nucle\u0301aire. Cette contamination endommage l’ADN, les tissus, les organes…<\/p>\n

Comment lutter contre un tel mal ? L’une des solutions est de retirer les e\u0301le\u0301ments radioactifs du corps aussi rapidement que possible, lorsque la contamination a eu lieu. Et c’est la\u0300 qu’intervient le me\u0301dicament HOPO 14-1. Lors d’un premier essai clinique chez l’humain (phase 1), l’entreprise SRI International, fonde\u0301e par l’Universite\u0301 de Stanford, va d’abord tester l’innocuite\u0301, la tole\u0301rance et l’e\u0301volution du me\u0301dicament dans le corps humain, a\u0300 l’aide de doses croissantes de produit.<\/p>\n

Pour cette e\u0301tude, 42 participants ont e\u0301te\u0301 recrute\u0301s, a\u0302ge\u0301s de 18 a\u0300 65 ans. Ils seront divise\u0301s en 7 groupes de six personnes : \u00ab\u00a0Chaque participant du premier groupe recevra une dose de 100 milligrammes (mg) de HOPO 14-1. Les groupes suivants recevront des doses de plus en plus e\u0301leve\u0301es du me\u0301dicament a\u0300 l’e\u0301tude jusqu’a\u0300 7500 mg dans le groupe final, si des doses plus faibles sont juge\u0301es su\u0302res\u00a0\u00bb, expliquent les NIH – qui financent l’e\u0301tude – dans un communique\u0301. Chaque participant sera e\u0301troitement surveille\u0301, au moins durant 14 jours, afin de mesurer l’absorption, la distribution dans l’organisme, et l’e\u0301limination du me\u0301dicament.<\/p>\n

Une simple capsule a\u0300 inge\u0301rer<\/b><\/p>\n

La Food and Drug Administration, l’organisme de re\u0301gulation des me\u0301dicaments aux Etats-Unis, approuve deux produits destine\u0301s a\u0300 limiter la contamination radioactive interne. Leur efficacite\u0301 est base\u0301e sur la me\u0302me mole\u0301cule : le DTPA. Administre\u0301s par voie intraveineuse, ils peuvent e\u0301liminer trois e\u0301le\u0301ments radioactifs : le curium, le plutonium et l’ame\u0301ricium.<\/p>\n

\u00ab\u00a0En revanche, HOPO 14-1 a e\u0301te\u0301 formule\u0301 sous forme de capsule orale, ce qui serait plus facile qu’un me\u0301dicament intraveineux a\u0300 stocker, a\u0300 de\u0301ployer et a\u0300 administrer en cas d’urgence, remarquent les agences sanitaires ame\u0301ricaines. La recherche pre\u0301clinique a montre\u0301 que HOPO 14-1 peut e\u0301liminer efficacement de nombreux contaminants radioactifs, y compris l’uranium et le neptunium en plus du plutonium, de l’ame\u0301ricium et du curium\u00a0\u00bb. En outre, HOPO 14-1, dont le compose\u0301 actif prend le nom de 3,4,3-LI(1,2-HOPO), serait 100 fois plus efficace que le DTPA pour se lier et e\u0301liminer ces e\u0301le\u0301ments.<\/p>\n

Pour plus d’informations et d’analyses sur la Djibouti<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Djibouti. La guerre en Ukraine fait planer depuis plusieurs mois un risque nucle\u0301aire, d’abord avec la menace d’une attaque atomique, et tre\u0300s re\u0301cemment, avec la situation critique a\u0300 la centrale nucle\u0301aire de Zaporijjia. Hasard du calendrier, les National Institutes of Health (NIH) – agences nationales ame\u0301ricaines de recherche me\u0301dicale – ont annonce\u0301, le […]<\/p>\n","protected":false},"author":82,"featured_media":12590,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,49,50],"class_list":["post-12591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-djibouti","tag-djibouti"],"yoast_head":"\nUn m\u00e9dicament oral destin\u00e9 \u00e0 \u00e9liminer une contamination radioactive test\u00e9 chez l'humain - Djibouti<\/title>\n<meta name=\"description\" content=\"La guerre en Ukraine fait planer depuis plusieurs mois un risque nucle\u0301aire, d'abord avec la menace d'une attaque atomiq ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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