{"id":18977,"date":"2024-02-27T17:21:50","date_gmt":"2024-02-27T17:21:50","guid":{"rendered":"https:\/\/www.africa-press.net\/guinee-conakry\/politique\/la-mutation-qui-fait-passer-escherichia-coli-dinoffensive-a-dangereuse"},"modified":"2024-02-27T18:56:49","modified_gmt":"2024-02-27T18:56:49","slug":"la-mutation-qui-fait-passer-escherichia-coli-dinoffensive-a-dangereuse","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/guinee-conakry\/toutes-les-actualites\/la-mutation-qui-fait-passer-escherichia-coli-dinoffensive-a-dangereuse","title":{"rendered":"La mutation qui fait passer Escherichia coli d\u2019inoffensive \u00e0 dangereuse"},"content":{"rendered":"

Africa-Press – Guin\u00e9e. <\/strong><\/span>Le monde des bacte\u0301ries nous demeure largement inconnu. Dernier exemple en date avec pourtant l\u2019une des plus communes qui soit: Escherichia coli. En effet, celle-ci se niche dans le tube digestif de l\u2019e\u0302tre humain et plus ge\u0301ne\u0301ralement dans celui de tous les animaux a\u0300 sang chaud. La plupart du temps, elle est totalement inoffensive.<\/p>\n

Des bonnes et des mauvaises Escherichia coli<\/b><\/p>\n

Pourtant, elle est e\u0301galement a\u0300 l\u2019origine de plusieurs maladies tre\u0300s se\u0301ve\u0300res, comme des infections intestinales, urinaires, cutane\u0301es, pulmonaires ou encore, chez le nouveau-ne\u0301, des me\u0301ningites. Dans le pire des cas, la bacte\u0301rie peut donc envahir malicieusement tous les organes, du cerveau au foie. Il pourrait donc exister de \u201cbonnes\u201d E.coli et des \u201cmauvaises\u201d. Mais qu\u2019est-ce qui distingue les deux types ?<\/p>\n

Mark Schembri et Nhu Nguyen de l\u2019universite\u0301 du Queensland (Australie), et leur e\u0301quipe, ont mis le doigt sur l\u2019un des processus qui transformerait la bacte\u0301rie commensale en pathoge\u0300ne. Ils publient leurs re\u0301sultats dans la revue Nature Communications.<\/p>\n

Une mutation qui empe\u0302che la bacte\u0301rie de fabriquer de la cellulose<\/b><\/p>\n

En analysant une se\u0301rie de ge\u0301nomes d\u2019une souche d\u2019E.coli tre\u0300s pathoge\u0300ne, les chercheurs ont ainsi identifie\u0301 une mutation qui empe\u0302che la bacte\u0301rie de fabriquer de la cellulose.<\/p>\n

Cette mole\u0301cule organique connue pour constituer la paroi cellulaire de nombreux ve\u0301ge\u0301taux est e\u0301galement synthe\u0301tise\u0301e par les bacte\u0301ries. Gra\u0302ce a\u0300 la cellulose, les bacte\u0301ries peuvent fabriquer des fibres tre\u0300s adhe\u0301sives et protectrices leur permettant de se rassembler en communaute\u0301s multicellulaires symbiotiques nomme\u0301es biofilms.<\/p>\n

5 millions de de\u0301ce\u0300s par an<\/b><\/p>\n

Les chercheurs australiens ont de\u0301montre\u0301 que les bacte\u0301ries E.coli pathoge\u0300nes sont pourvues d\u2019une mutation qui empe\u0302che, ou a\u0300 tout le moins re\u0301duit, leur synthe\u0300se de cellulose. Cela conduit a\u0300 une augmentation de l\u2019inflammation de l\u2019ho\u0302te et a\u0300 une rupture de la barrie\u0300re intestinale. Plus virulente, E.coli devient alors capable de se disse\u0301miner largement et d\u2019envahir d\u2019autres organes de l\u2019individu, et au-dela\u0300, d\u2019infecter d\u2019autres organismes.<\/p>\n

En outre, le phe\u0301nome\u0300ne ne concernerait pas uniquement cette bacte\u0301rie. Les analyses ge\u0301nomiques ont re\u0301ve\u0301le\u0301 aux scientifiques que l\u2019absence de fabrication de cellulose se retrouvait e\u0301galement chez plusieurs souches de Shigella et de Salmonella associe\u0301es a\u0300 de se\u0301ve\u0300res maladies e\u0301pide\u0301miques.<\/p>\n

Alors que la re\u0301sistance aux antibiotiques est devenue un enjeu majeur de sante\u0301 publique et que chaque anne\u0301e, plus de cinq millions de de\u0301ce\u0300s sont cause\u0301s par des bacte\u0301ries insensibles a\u0300 tout traitement, dont 800.000 par E.coli, il devient urgent, pre\u0301viennent les chercheurs, de trouver des parades pour re\u0301duire les contagions inter-humaines.<\/p>\n

Pour plus d’informations et d’analyses sur la Guin\u00e9e<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Guin\u00e9e. Le monde des bacte\u0301ries nous demeure largement inconnu. Dernier exemple en date avec pourtant l\u2019une des plus communes qui soit: Escherichia coli. En effet, celle-ci se niche dans le tube digestif de l\u2019e\u0302tre humain et plus ge\u0301ne\u0301ralement dans celui de tous les animaux a\u0300 sang chaud. La plupart du temps, elle est […]<\/p>\n","protected":false},"author":82,"featured_media":18976,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,57,58],"class_list":["post-18977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-guinee","tag-guinee"],"yoast_head":"\nLa mutation qui fait passer Escherichia coli d\u2019inoffensive \u00e0 dangereuse - guinee Conakry<\/title>\n<meta name=\"description\" content=\"Le monde des bacte\u0301ries nous demeure largement inconnu. 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