{"id":24814,"date":"2022-09-18T15:53:33","date_gmt":"2022-09-18T15:53:33","guid":{"rendered":"https:\/\/www.africa-press.net\/mali\/politique\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus"},"modified":"2022-09-18T17:20:40","modified_gmt":"2022-09-18T17:20:40","slug":"cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus","title":{"rendered":"Cet anticorps neutralisant s\u2019attaque \u00e0 tous les variants connus du coronavirus"},"content":{"rendered":"

Africa-Press – Mali. <\/strong><\/span>Un anticorps th\u00e9rapeutique qui neutralise tous les variants connus du coronavirus fait l\u2019objet d\u2019une publication r\u00e9cente dans un journal reconnu. Qu\u2019a-t-il de plus que les autres ?<\/p>\n

L\u2019arriv\u00e9e de chaque variant du SARS-CoV-2 menace l\u2019efficacit\u00e9 des vaccins et des anticorps th\u00e9rapeutiques disponibles. Omicron est si diff\u00e9rent des autres qu\u2019il a mis en \u00e9chec la plupart d\u2019entre eux prescrits avant son arriv\u00e9e. Les scientifiques esp\u00e8rent mettre au point un anticorps qui pourrait neutraliser tous les variants du SARS-CoV-2. Celui pr\u00e9sent\u00e9 r\u00e9cemment dans Science Immunology n\u2019est pas le premier ni le dernier, mais il a un atout qu\u2019il le rend digne d\u2019int\u00e9r\u00eat.<\/p>\n

Un anticorps neutralisant contre tous les variants<\/p>\n

SP1-77, c\u2019est son nom, a \u00e9t\u00e9 obtenu gr\u00e2ce \u00e0 des souris de laboratoire g\u00e9n\u00e9tiquement modifi\u00e9es pour produire des anticorps humanis\u00e9s \u2014 des anticorps de souris dont certains fragments sont humains. Pour isoler ceux qui r\u00e9agissent au SARS-CoV-2, les scientifiques les ont mis en contact avec la souche originelle de Wuhan. Parmi tous les anticorps qui ont r\u00e9agi, seul SP1-77 \u00e9tait capable de neutraliser la souche de Wuhan et tous les autres variants connus dont ceux de la famille Omicron.<\/p>\n

Qu\u2019est-ce qui rend SP1-77 si sp\u00e9cial ? Les scientifiques ont \u00e9tudi\u00e9 sa structure gr\u00e2ce \u00e0 la cryomicroscopie \u00e9lectronique, une technique qui permet de visualiser les anticorps \u00e0 l\u2019acide amin\u00e9 pr\u00e8s. Comme la plupart des anticorps neutralisants, SP1-77 se fixe sur le RBD, la partie du coronavirus qui interagit avec le r\u00e9cepteur de la cellule. Mais il neutralise le virus d\u2019une fa\u00e7on in\u00e9dite. SP1-77 n\u2019emp\u00eache pas la reconnaissance entre le RBD et ACE2 mais bloque l\u2019\u00e9tape suivante, la fusion entre la membrane du virus et celle de la cellule des deux membranes, indispensable pour que le virus infecte sa cellule h\u00f4te.<\/p>\n

De plus \u00ab SP1-77 se fixe sur un endroit de la prot\u00e9ine S qui n\u2019a pas \u00e9t\u00e9 mut\u00e9 dans aucun variant du SARS-coV-2 jusqu\u2019alors, neutralisant donc les variants gr\u00e2ce \u00e0 un nouveau m\u00e9canisme \u00bb, explique Tom Kirchhausen du Boston Children\u2019s Hospital.<\/p>\n

Cette \u00e9tude est avant tout une preuve de concept que les souris utilis\u00e9es par les scientifiques sont capables de produire des anticorps humanis\u00e9s neutralisants contre le SARS-CoV-2. Si SP1-77 montre des capacit\u00e9s int\u00e9ressantes in vitro, rien ne permet de conclure qu\u2019il est un candidat s\u00e9rieux pour \u00eatre un nouvel anticorps th\u00e9rapeutique utile pour soigner la Covid-19.<\/p>\n

Pour plus d’informations et d’analyses sur la Mali<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Mali. Un anticorps th\u00e9rapeutique qui neutralise tous les variants connus du coronavirus fait l\u2019objet d\u2019une publication r\u00e9cente dans un journal reconnu. Qu\u2019a-t-il de plus que les autres ? L\u2019arriv\u00e9e de chaque variant du SARS-CoV-2 menace l\u2019efficacit\u00e9 des vaccins et des anticorps th\u00e9rapeutiques disponibles. Omicron est si diff\u00e9rent des autres qu\u2019il a mis en […]<\/p>\n","protected":false},"author":82,"featured_media":24813,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,11,17],"tags":[76,86,19],"class_list":["post-24814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-homepage-french","category-toutes-les-actualites","tag-africa-press","tag-africa-press-mali","tag-mali"],"yoast_head":"\nCet anticorps neutralisant s\u2019attaque \u00e0 tous les variants connus du coronavirus - Mali<\/title>\n<meta name=\"description\" content=\"Un anticorps th\u00e9rapeutique qui neutralise tous les variants connus du coronavirus fait l\u2019objet d\u2019une publication r\u00e9cente ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cet anticorps neutralisant s\u2019attaque \u00e0 tous les variants connus du coronavirus\" \/>\n<meta property=\"og:description\" content=\"Un anticorps th\u00e9rapeutique qui neutralise tous les variants connus du coronavirus fait l\u2019objet d\u2019une publication r\u00e9cente ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\" \/>\n<meta property=\"og:site_name\" content=\"Mali\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AfricaPressTunisiaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-18T15:53:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-18T17:20:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/mali\/sites\/21\/2022\/09\/postQueueImg_9-6327534ecf947.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1520\" \/>\n\t<meta property=\"og:image:height\" content=\"875\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/mali\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Cet anticorps neutralisant s\u2019attaque \u00e0 tous les variants connus du coronavirus\",\"datePublished\":\"2022-09-18T15:53:33+00:00\",\"dateModified\":\"2022-09-18T17:20:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\"},\"wordCount\":462,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/mali\/sites\/21\/2022\/09\/postQueueImg_9-6327534ecf947.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Mali\",\"mali\"],\"articleSection\":[\"Divers\",\"homepage-french\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\",\"url\":\"https:\/\/www.africa-press.net\/mali\/homepage-french\/cet-anticorps-neutralisant-sattaque-a-tous-les-variants-connus-du-coronavirus\",\"name\":\"Cet anticorps neutralisant s\u2019attaque \u00e0 tous les variants connus du coronavirus - 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