{"id":55869,"date":"2023-10-13T15:22:11","date_gmt":"2023-10-13T15:22:11","guid":{"rendered":"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu"},"modified":"2023-10-13T17:11:41","modified_gmt":"2023-10-13T17:11:41","slug":"scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu","title":{"rendered":"Scientists Use CRISPR Gene Editing Tech on Chickens to Fight Bird Flu"},"content":{"rendered":"

Africa-Press – Namibia. <\/strong><\/span>According to a New York journal, the deadliest bird flu outbreak occurred between February 2022 and February 2023, killing 58 million farm-raised birds in the US, and leading to record high turkey prices.<\/p>\n

After three decades of research, Helen Sang, a geneticist at the University of Edinburgh\u2019s Roslin Institute, reached her first success in gene editing by creating chickens that demonstrate a resistance to the avian flu.<\/p>\n

Sang and her colleagues wrote in their findings that in chickens, the influenza A virus (IAV) relies on host protein ANP32A. In their study they a particular approach to genome editing known as CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats) to generate \u201chomozygous gene edited chickens containing two ANP32A amino acid substitutions that prevent viral polymerase interaction.\u201d<\/p>\n

The team put the avian influenza virus into the nostrils of 20 two-week-old chicks, half of which were subject to the modified gene. After the IAV challenge, the researchers wrote, at least nine out of 10 chicks (nearly the entire half) \u201cremain uninfected.\u201d<\/p>\n

However, this system will not be put to the test anytime soon, as the gene-edited chickens still became sick when they were exposed to larger amounts of the flu virus, even though the infections did develop more slowly, reaching lower viral levels,<\/p>\n

In addition, the researchers say that if a mutated virus does arise to confront the gene-edited chickens, it would have a \u201chigh probability\u201d of better infecting mammals – including humans.<\/p>\n

\u201cA water-tight system where no more replication takes place in chickens is necessary,\u201d Sander Herfst, a virologist from Erasmus University Medical Center, said. To accomplish their goal, the scientists will have to continue to use the genome editing approach (CRISPR-Cas9) in their tests.<\/p>\n

Additionally, per Barclay, test tube experiments showed that even high levels of the influenza virus could not infect chicken cells if that virus lacked all three ANP32 genes.<\/p>\n

However, the researchers will have to find a way to keep the chickens healthy too, as removing all three genes could have a negative effect on the chicken\u2019s health. The goal then, would be to find a way to alter the ANP32 gene so that it could ward off the virus, but still be able to function as a protein.<\/p>\n

Still, the discovery is one step further in scientists\u2019 efforts to prevent virus outbreaks.<\/p>\n

Richard Webby, a bird flu expert at St. Jude Children\u2019s Research Hospital, said the scientific community would “absolutely” reach the point where researchers will be able to \u201cmanipulate the host genome to make them less susceptible to flu. That\u2019ll be a win for public health.\u201d<\/p>\n

The findings were published Tuesday in the journal Nature Communications.<\/p>\n

For More News And Analysis About Namibia<\/a> Follow Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Namibia. According to a New York journal, the deadliest bird flu outbreak occurred between February 2022 and February 2023, killing 58 million farm-raised birds in the US, and leading to record high turkey prices. After three decades of research, Helen Sang, a geneticist at the University of Edinburgh\u2019s Roslin Institute, reached her first […]<\/p>\n","protected":false},"author":84,"featured_media":55868,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,9],"tags":[234,236,233],"class_list":["post-55869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news","category-miscellaneous","tag-africa-press","tag-africa-press-namibia","tag-namibia"],"yoast_head":"\nScientists Use CRISPR Gene Editing Tech on Chickens to Fight Bird Flu - Namibia<\/title>\n<meta name=\"description\" content=\"According to a New York journal, the deadliest bird flu outbreak occurred between February 2022 and February 2023, killi ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Use CRISPR Gene Editing Tech on Chickens to Fight Bird Flu\" \/>\n<meta property=\"og:description\" content=\"According to a New York journal, the deadliest bird flu outbreak occurred between February 2022 and February 2023, killi ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\" \/>\n<meta property=\"og:site_name\" content=\"Namibia\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AfricaPressTunisiaa\" \/>\n<meta property=\"article:published_time\" content=\"2023-10-13T15:22:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-13T17:11:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/nambia\/sites\/29\/2023\/10\/sm_1697204439.272489.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditoren\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditoren\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\"},\"author\":{\"name\":\"cfeditoren\",\"@id\":\"https:\/\/www.africa-press.net\/namibia\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb\"},\"headline\":\"Scientists Use CRISPR Gene Editing Tech on Chickens to Fight Bird Flu\",\"datePublished\":\"2023-10-13T15:22:11+00:00\",\"dateModified\":\"2023-10-13T17:11:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\"},\"wordCount\":464,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/nambia\/sites\/29\/2023\/10\/sm_1697204439.272489.jpg\",\"keywords\":[\"africa press\",\"Africa Press-Namibia\",\"namibia\"],\"articleSection\":[\"all news\",\"miscellaneous\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\",\"url\":\"https:\/\/www.africa-press.net\/namibia\/all-news\/scientists-use-crispr-gene-editing-tech-on-chickens-to-fight-bird-flu\",\"name\":\"Scientists Use CRISPR Gene Editing Tech on Chickens to Fight Bird Flu - 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