{"id":60485,"date":"2023-12-12T16:38:43","date_gmt":"2023-12-12T16:38:43","guid":{"rendered":"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness"},"modified":"2023-12-12T17:35:19","modified_gmt":"2023-12-12T17:35:19","slug":"hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness","title":{"rendered":"HIV vaccine trial in Africa halted due to ineffectiveness"},"content":{"rendered":"<p><span style=\"color: #ff6600\"><strong>Africa-Press &#8211; Rwanda. <\/strong><\/span>The initial attempt in Africa to assess the efficacy of two combined vaccines against HIV has been terminated as researchers determined that the intervention was ineffective.<\/p>\n<p>The trial involved 1,500 participants aged 18 to 40 in Uganda, Tanzania, and South Africa. Conducted under African leadership, the trial commenced in December 2020 and was discontinued last month following an interim assessment of its advancement.<\/p>\n<p>Dr Eugene Ruzagira, trial director from the Uganda Virus Research Institute (UVRI) and assistant professor of epidemiology at the London School of Hygiene and Tropical Medicine, told UK\u2019s The Guardian that an analysis of the data collected by an independent data-monitoring committee led them to conclude that there is \u201clittle or no chance of demonstrating that the vaccines we are testing are reducing the risk of acquiring HIV.\u201d<\/p>\n<p>Led by African researchers with support from European scientists, the trials tested two different combinations of HIV vaccines to see if either could prevent infection in populations particularly at risk of infection.<\/p>\n<p>Prof Jonathan Weber, from Imperial College London, one of the trial\u2019s sponsors, said:<\/p>\n<p>\u201cWe do clinical trials because we don\u2019t know the answer to questions. It was important to find out whether the combination vaccine regimens in PrEPVacc, developed over 20 years, should be ruled out or further developed for preventing HIV.\u201d<\/p>\n<p>\u201cWhile we await the final results and analysis of individual products, I believe that our interim result puts this generation of putative HIV vaccines to bed,\u201d he added.<\/p>\n<p>Previous trials in South Africa to test the only vaccine that had shown any success in protecting against HIV \u2013 the RV144 \u2013 developed in Thailand, was stopped in February 2020 after interim results found it was not working.<\/p>\n<p>Prof. Pontiano Kaleebu, PrEPVacc\u2019s chief investigator at UVRI, said developing an effective vaccine to prevent HIV infection was \u201ca critical goal for Africa\u201d.<\/p>\n<p>He said: \u201cIt is a goal that must have even greater urgency now that no HIV vaccines are being trialled for efficacy anywhere in the world.<\/p>\n<p>\u201cWe have come so far in our HIV-prevention journey, but we must look to a new generation of vaccine approaches and technology to take us forward again.\u201d<\/p>\n<p>About 39 million people worldwide are living with HIV, more than 25 million in sub-Saharan Africa.<\/p>\n<p><strong>For More News And Analysis About <a href=\"https:\/\/www.africa-press.net\/rwanda\">Rwanda<\/a> Follow <a href=\"https:\/\/www.africa-press.net\/\">Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Africa-Press &#8211; Rwanda. The initial attempt in Africa to assess the efficacy of two combined vaccines against HIV has been terminated as researchers determined that the intervention was ineffective. The trial involved 1,500 participants aged 18 to 40 in Uganda, Tanzania, and South Africa. Conducted under African leadership, the trial commenced in December 2020 and [&hellip;]<\/p>\n","protected":false},"author":84,"featured_media":60484,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24,30],"tags":[760,763,758],"class_list":["post-60485","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news","category-community","tag-africa-press","tag-africa-press-rwanda","tag-rwanda"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>HIV vaccine trial in Africa halted due to ineffectiveness - Rwanda<\/title>\n<meta name=\"description\" content=\"The initial attempt in Africa to assess the efficacy of two combined vaccines against HIV has been terminated as researc ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HIV vaccine trial in Africa halted due to ineffectiveness\" \/>\n<meta property=\"og:description\" content=\"The initial attempt in Africa to assess the efficacy of two combined vaccines against HIV has been terminated as researc ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\" \/>\n<meta property=\"og:site_name\" content=\"Rwanda\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-12T16:38:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-12T17:35:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2023\/12\/sm_1702389868.911574.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"695\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditoren\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditoren\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\"},\"author\":{\"name\":\"cfeditoren\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb\"},\"headline\":\"HIV vaccine trial in Africa halted due to ineffectiveness\",\"datePublished\":\"2023-12-12T16:38:43+00:00\",\"dateModified\":\"2023-12-12T17:35:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\"},\"wordCount\":389,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2023\/12\/sm_1702389868.911574.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Rwanda\",\"Rwanda\"],\"articleSection\":[\"all news\",\"Community\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\",\"url\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/hiv-vaccine-trial-in-africa-halted-due-to-ineffectiveness\",\"name\":\"HIV vaccine trial in Africa halted due to ineffectiveness - 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