{"id":72276,"date":"2024-05-07T16:01:56","date_gmt":"2024-05-07T16:01:56","guid":{"rendered":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study"},"modified":"2024-05-07T16:10:38","modified_gmt":"2024-05-07T16:10:38","slug":"alzheimers-likelihood-linked-to-genetics-says-new-study","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study","title":{"rendered":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study"},"content":{"rendered":"

Africa-Press – Rwanda. <\/strong><\/span>Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all patients who carry at least one copy of it.<\/p>\n

As a first in medical history, researchers have identified a genetic form of Alzheimer\u2019s disease. This means that the disease could be inherited more often than previously thought; just 1 in 50 cases of the disease were thought to be based on familial forms.<\/p>\n

But according to a study, published on Monday in the journal Nature Medicine, 1 in 6 cases of Alzheimer\u2019s could be considered inherited.<\/b><\/p>\n

According to the Centers for Disease Control and Prevention (CDC), Alzheimer\u2019s disease is the most common type of dementia. It is a progressive disease beginning with mild memory loss and can possibly lead to the loss of being able to carry on a conversation or respond to one\u2019s environment. It affects parts of the brain that control thought, memory and language.<\/p>\n

Prior to Monday’s publication, scientists have been aware of a gene called APOE4 that can increase people\u2019s risk of developing Alzheimer\u2019s. APOE makes a protein that is responsible for carrying cholesterol throughout the body and brain and is believed to play a role in monitoring beta amyloid plaques which disrupt cell function.<\/p>\n

APOE4 is one of three subtypes of the APOE gene. And those who have at least one copy of this gene type have an elevated risk of developing Alzheimer\u2019s disease, while people with two copies of the gene have an even higher risk.<\/p>\n

But authors of the new study say the gene is not just a risk factor – it is an inherited form of the disease and essentially guarantees that any person with two copies of the gene will experience the biological changes of Alzheimer\u2019s disease in their brains. APOE4 could also result in patients experiencing symptoms at an earlier rate – about 10 years earlier – than those without.<\/b><\/p>\n

The researchers found that those with two copies of the APOE4 gene were accumulating more amyloid at age 55 than those with just one copy of a \u201cneutral\u201d gene variant, APOE3. Then, at the age of 65, brain scans showed significant plaque buildup in almost three-quarters of double carriers.<\/p>\n

\u201cThe critical thing is that these individuals are often symptomatic 10 years earlier than other forms of Alzheimer\u2019s disease,\u201d said Dr. Reisa Sperling, a neurologist at Mass General Brigham in Boston and a co-author of the study. \u201cBy the time they are picked up and clinically diagnosed, because they\u2019re often younger, they have more pathology.\u201d<\/p>\n

Sperling said it isn\u2019t clear if those who carry two APOE4 genes would benefit from the drug Leqembi, which works to clear away amyloid, especially because they are at a high risk to the side effects of the drug which includes dangerous brain swelling and bleeding.<\/p>\n

A gene test for those that carry two APOE4 genes is also uncommon. But if one\u2019s parents both developed Alzheiemr\u2019s relatively early – in their 60s rather than their 80s – they most likely carry two APOE4 genes.<\/p>\n

For More News And Analysis About Rwanda<\/a> Follow Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Rwanda. Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all patients who carry at least one copy of it. As a first in medical history, researchers have identified a genetic form of Alzheimer\u2019s disease. This means that the disease could be […]<\/p>\n","protected":false},"author":84,"featured_media":72275,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24,31],"tags":[760,763,758],"class_list":["post-72276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news","category-miscellaneous","tag-africa-press","tag-africa-press-rwanda","tag-rwanda"],"yoast_head":"\nAlzheimer\u2019s Likelihood Linked to Genetics, Says New Study - Rwanda<\/title>\n<meta name=\"description\" content=\"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study\" \/>\n<meta property=\"og:description\" content=\"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\" \/>\n<meta property=\"og:site_name\" content=\"Rwanda\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-07T16:01:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-07T16:10:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditoren\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditoren\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\"},\"author\":{\"name\":\"cfeditoren\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb\"},\"headline\":\"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study\",\"datePublished\":\"2024-05-07T16:01:56+00:00\",\"dateModified\":\"2024-05-07T16:10:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\"},\"wordCount\":536,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Rwanda\",\"Rwanda\"],\"articleSection\":[\"all news\",\"Miscellaneous\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\",\"url\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\",\"name\":\"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study - Rwanda\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg\",\"datePublished\":\"2024-05-07T16:01:56+00:00\",\"dateModified\":\"2024-05-07T16:10:38+00:00\",\"author\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb\"},\"description\":\"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...\",\"breadcrumb\":{\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage\",\"url\":\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg\",\"contentUrl\":\"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg\",\"width\":1280,\"height\":720,\"caption\":\"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.africa-press.net\/rwanda\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#website\",\"url\":\"https:\/\/www.africa-press.net\/rwanda\/\",\"name\":\"Rwanda\",\"description\":\"Just another Africa News Agency Sites site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.africa-press.net\/rwanda\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb\",\"name\":\"cfeditoren\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study - Rwanda","description":"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study","og_locale":"en_US","og_type":"article","og_title":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study","og_description":"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...","og_url":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study","og_site_name":"Rwanda","article_published_time":"2024-05-07T16:01:56+00:00","article_modified_time":"2024-05-07T16:10:38+00:00","og_image":[{"width":1280,"height":720,"url":"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg","type":"image\/jpeg"}],"author":"cfeditoren","twitter_card":"summary_large_image","twitter_misc":{"Written by":"cfeditoren","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#article","isPartOf":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study"},"author":{"name":"cfeditoren","@id":"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb"},"headline":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study","datePublished":"2024-05-07T16:01:56+00:00","dateModified":"2024-05-07T16:10:38+00:00","mainEntityOfPage":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study"},"wordCount":536,"commentCount":0,"image":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage"},"thumbnailUrl":"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg","keywords":["Africa Press","Africa Press-Rwanda","Rwanda"],"articleSection":["all news","Miscellaneous"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study","url":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study","name":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study - Rwanda","isPartOf":{"@id":"https:\/\/www.africa-press.net\/rwanda\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage"},"image":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage"},"thumbnailUrl":"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg","datePublished":"2024-05-07T16:01:56+00:00","dateModified":"2024-05-07T16:10:38+00:00","author":{"@id":"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb"},"description":"Further research will be needed to develop gene therapy or drugs that target the gene which accounts for half of all pat ...","breadcrumb":{"@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#primaryimage","url":"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg","contentUrl":"https:\/\/static.africa-press.net\/rwanda\/sites\/23\/2024\/05\/sm_1715085541.508243.jpg","width":1280,"height":720,"caption":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study"},{"@type":"BreadcrumbList","@id":"https:\/\/www.africa-press.net\/rwanda\/all-news\/alzheimers-likelihood-linked-to-genetics-says-new-study#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.africa-press.net\/rwanda\/"},{"@type":"ListItem","position":2,"name":"Alzheimer\u2019s Likelihood Linked to Genetics, Says New Study"}]},{"@type":"WebSite","@id":"https:\/\/www.africa-press.net\/rwanda\/#website","url":"https:\/\/www.africa-press.net\/rwanda\/","name":"Rwanda","description":"Just another Africa News Agency Sites site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.africa-press.net\/rwanda\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.africa-press.net\/rwanda\/#\/schema\/person\/068c7ab4e9634ae78ec5d54ec46598bb","name":"cfeditoren"}]}},"_links":{"self":[{"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/posts\/72276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/comments?post=72276"}],"version-history":[{"count":0,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/posts\/72276\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/media\/72275"}],"wp:attachment":[{"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/media?parent=72276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/categories?post=72276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.africa-press.net\/rwanda\/wp-json\/wp\/v2\/tags?post=72276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}