{"id":10571,"date":"2023-12-12T19:16:02","date_gmt":"2023-12-12T19:16:02","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/larret-dun-nouveau-medicament-anti-obesite-entraine-une-reprise-de-poids"},"modified":"2023-12-12T21:35:09","modified_gmt":"2023-12-12T21:35:09","slug":"larret-dun-nouveau-medicament-anti-obesite-entraine-une-reprise-de-poids","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/larret-dun-nouveau-medicament-anti-obesite-entraine-une-reprise-de-poids","title":{"rendered":"L\u2019arr\u00eat d\u2019un nouveau m\u00e9dicament anti-ob\u00e9sit\u00e9 entra\u00eene une reprise de poids"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Une nouvelle ge\u0301ne\u0301ration de me\u0301dicaments contre l\u2019obe\u0301site\u0301 suscite depuis des mois l\u2019engouement de millions de patients et du secteur pharmaceutique \u2013 et une question : que se passe-t-il en cas d\u2019arre\u0302t de ces traitements ?<\/b>
\nDes me\u0301dicaments qui imitent la GLP-1, une hormone secre\u0301te\u0301e par les intestins<\/b><\/p>\n

Selon une e\u0301tude publie\u0301e lundi 11 de\u0301cembre 2023, une partie importante du poids perdu sous traitement revient une fois qu\u2019il est mis fin a\u0300 celui-ci, indiquant que ces nouvelles mole\u0301cules pourraient cre\u0301er une forme de de\u0301pendance de long terme.<\/p>\n

L\u2019e\u0301tude, publie\u0301e dans le Journal of the American Medical Association, a e\u0301te\u0301 mene\u0301e avec la tirzepatide, une mole\u0301cule du laboratoire ame\u0301ricain Eli Lilly pre\u0301sente dans le Zepbound, approuve\u0301 en novembre aux Etats-Unis comme traitement contre l\u2019obe\u0301site\u0301, maladie dont environ 40% des adultes souffrent dans le pays.<\/p>\n

Le Zepbound fait partie, avec Wegovy, Mounjaro et Ozempic notamment, de la re\u0301cente vague de me\u0301dicaments qui affolent le secteur pharmaceutique et nourrissent les espoirs de millions de malades a\u0300 travers le monde avec leur proprie\u0301te\u0301s tre\u0300s attractives : ils soignent le diabe\u0300te de type 2, font maigrir et peuvent e\u0302tre utilise\u0301s pour traiter l\u2019obe\u0301site\u0301.<\/p>\n

Ces me\u0301dicaments imitent une hormone secre\u0301te\u0301e par les intestins, GLP-1 (abre\u0301viation de glugaco-like peptide 1) qui stimule la se\u0301cre\u0301tion d\u2019insuline et re\u0301fre\u0300ne l\u2019appe\u0301tit en procurant une sensation de satie\u0301te\u0301.<\/p>\n

La moitie\u0301 du poids perdu<\/b><\/p>\n

Dans l\u2019e\u0301tude publie\u0301e lundi, une cohorte de 670 patients a d\u2019abord pris une dose de Zepbound en injection hebdomadaire, leur faisant perdre en moyenne 21% de leur poids apre\u0300s 36 semaines.<\/p>\n

Ils ont ensuite e\u0301te\u0301 se\u0301pare\u0301s en deux groupes : l\u2019un continue de recevoir du Zepbound, l\u2019autre un placebo. Au bout de 88 semaines (plus d\u2019un an et demi), ceux qui ont rec\u0327u le placebo ont regagne\u0301 pre\u0300s de la moitie\u0301 du poids perdu, avec un poids tout de me\u0302me 10% plus faible qu\u2019au tout de\u0301but du traitement.<\/p>\n

Le groupe avec du Zepbound a lui continue\u0301 de perdre du poids, avec une masse corporelle 25% plus faible qu\u2019au de\u0301but.<\/p>\n

La cohorte e\u0301tait compose\u0301e de patients en Argentine, au Bre\u0301sil, a\u0300 Tai\u0308wan et aux Etats-Unis, avec une moyenne d\u2019a\u0302ge de 48 ans, environ 70% de femmes et un poids au de\u0301but de 107 kilo en moyenne.<\/p>\n

Ils ont tous rec\u0327u des conseils pour manger moins et faire de l\u2019exercice. Ces re\u0301sultats \u201cmettent en e\u0301vidence le besoin de poursuivre le traitement pour pre\u0301venir une reprise de poids et s\u2019assurer d\u2019une baisse continue de poids\u201d, ce qui apporte d\u2019importants be\u0301ne\u0301fices cardiaques, e\u0301crivent les auteurs.<\/p>\n

Traitement continu<\/b><\/p>\n

Leur publication montre, comme l\u2019avaient de\u0301ja\u0300 fait 4 autres essais cliniques, qu\u2019avec cette nouvelle ge\u0301ne\u0301ration de me\u0301dicaments, \u201cdu poids est repris de manie\u0300re importante\u201d en cas d\u2019arre\u0302t du traitement, re\u0301sument-ils.<\/p>\n

\u201cLes patients, les soignants et le public ne comprennent pas toujours que l\u2019obe\u0301site\u0301 est une maladie chronique qui demande un traitement continu, ce qui signifie que le traitement doit e\u0302tre stoppe\u0301 quand les objectifs de perte de poids sont atteints\u201d, a de\u0301clare\u0301 Jeff Emmick, un responsable du laboratoire Eli Lilly, dans un communique\u0301 de re\u0301action a\u0300 l\u2019e\u0301tude.<\/p>\n

Eli Lilly vend le Zepbound a\u0300 1.060 dollars par mois aux Etats-Unis \u2013 un prix e\u0301leve\u0301, rarement rembourse\u0301 par les assurances sante\u0301 du pays.<\/p>\n

Cette nouvelle ge\u0301ne\u0301ration de me\u0301dicaments augmente le risque de proble\u0300mes gastro-intestinaux. Et me\u0302me s\u2019ils sont rarement graves, ces effets secondaires pourraient peut-e\u0302tre, selon des experts, finalement outrepasser les be\u0301ne\u0301fices du traitement si celui-ci doit e\u0302tre administre\u0301 sur le long terme.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. Une nouvelle ge\u0301ne\u0301ration de me\u0301dicaments contre l\u2019obe\u0301site\u0301 suscite depuis des mois l\u2019engouement de millions de patients et du secteur pharmaceutique \u2013 et une question : que se passe-t-il en cas d\u2019arre\u0302t de ces traitements ? Des me\u0301dicaments qui imitent la GLP-1, une hormone secre\u0301te\u0301e par les intestins Selon une […]<\/p>\n","protected":false},"author":82,"featured_media":10570,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-10571","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nL\u2019arr\u00eat d\u2019un nouveau m\u00e9dicament anti-ob\u00e9sit\u00e9 entra\u00eene une reprise de poids - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Une nouvelle ge\u0301ne\u0301ration de me\u0301dicaments contre l\u2019obe\u0301site\u0301 suscite depuis des mois l\u2019engouement de millions de pati ...\" \/>\n<meta name=\"robots\" content=\"index, follow, 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