{"id":10965,"date":"2023-12-30T16:39:34","date_gmt":"2023-12-30T16:39:34","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/chimie-click-une-chimie-qui-simplifie-la-physique-la-medecine-et-la-biologie"},"modified":"2023-12-30T18:40:34","modified_gmt":"2023-12-30T18:40:34","slug":"chimie-click-une-chimie-qui-simplifie-la-physique-la-medecine-et-la-biologie","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/chimie-click-une-chimie-qui-simplifie-la-physique-la-medecine-et-la-biologie","title":{"rendered":"Chimie click\u00a0: une chimie qui simplifie la physique, la m\u00e9decine et la biologie"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Cet article est issu du magazine Les Indispensables de Sciences et Avenir n\u00b0216 date\u0301 janvier\/ mars 2024.<\/p>\n

Cre\u0301er des mole\u0301cules organiques complexes en un minimum d\u2019e\u0301tapes est une gageure pour le chimiste. Mais pas avec la \u201cchimie click\u201d, dont l\u2019approche vise a\u0300 assembler n\u2019importe quels blocs mole\u0301culaires gra\u0302ce a\u0300 un ensemble limite\u0301 de re\u0301actions \u201cqui doivent avoir lieu dans des conditions douces \u2013 pas de haute tempe\u0301rature ni de pression \u2013 et donner des rendements e\u0301leve\u0301s sans former de produit inde\u0301sire\u0301\u201d, explique Fre\u0301de\u0301ric Taran, du Service de chimie bioorganique et de marquage de l\u2019Institut Fre\u0301de\u0301ric-Joliot. Cette technique a e\u0301te\u0301 mise au point inde\u0301pendamment en 2002 par l\u2019Ame\u0301ricain Barry Sharpless et le Danois Morten Meldal, qui de\u0301crocheront le prix Nobel 2022.<\/p>\n

\u201cSimple et efficace\u201d<\/b><\/p>\n

Leur ide\u0301e : pour unir deux blocs mole\u0301culaires, on les e\u0301quipe a\u0300 l\u2019une de leurs extre\u0301mite\u0301s d\u2019une petite unite\u0301 organique ayant une forte affinite\u0301 pour celle accroche\u0301e a\u0300 l\u2019autre. Il s\u2019agira d\u2019un azoture, soit trois atomes d\u2019azote lie\u0301s entre eux, et d\u2019un alcyne, soit deux atomes de carbone associe\u0301s par une triple liaison. Avec du cuivre en guise de catalyseur, l\u2019azoture et l\u2019alcyne re\u0301agiront rapidement pour former un anneau tre\u0300s stable unissant les deux chai\u0302nons atomiques.<\/p>\n

\u201cSimple et efficace, la chimie click, voire multi-click, a e\u0301te\u0301 adopte\u0301e par tous les chimistes organiciens, qui l\u2019ont de\u0301cline\u0301e pour fabriquer des me\u0301dicaments, des mate\u0301riaux, etc., s\u2019enthousiasme Fre\u0301de\u0301ric Taran. Mais c\u2019est dans l\u2019imagerie cellulaire et les the\u0301rapies cible\u0301es que ses applications sont remarquables.\u201d<\/p>\n

Adapter la chimie click au vivant<\/b><\/p>\n

Co-laure\u0301ate du Nobel, l\u2019Ame\u0301ricaine Carolyn Bertozzi a ainsi transpose\u0301 ce concept en biologie pour ame\u0301liorer la chimie dite \u201cbioorthogonale\u201d qui permet, au sein d\u2019une cellule, de re\u0301aliser des re\u0301actions artificielles ne perturbant pas ses processus habituels. Pour se passer du cuivre, non biocompatible, elle a eu recours a\u0300 un type d\u2019alcyne dit cyclique, coince\u0301 dans un anneau de carbone, ce qui en augmente la re\u0301activite\u0301.<\/p>\n

Adaptant la chimie click au vivant, elle est ainsi parvenue a\u0300 observer des glucides complexes, ou polysaccharides, a\u0300 la surface de membranes cellulaires, en fixant sur eux des mole\u0301cules fluorescentes. \u201cIl est ainsi possible de voir si un anti-cance\u0301reux atteint sa cible en lui injectant un marqueur radioactif ou fluorescent, conc\u0327u pour se clipser dessus\u201d, s\u2019enthousiasme Fre\u0301de\u0301ric Taran.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. Cet article est issu du magazine Les Indispensables de Sciences et Avenir n\u00b0216 date\u0301 janvier\/ mars 2024. Cre\u0301er des mole\u0301cules organiques complexes en un minimum d\u2019e\u0301tapes est une gageure pour le chimiste. Mais pas avec la \u201cchimie click\u201d, dont l\u2019approche vise a\u0300 assembler n\u2019importe quels blocs mole\u0301culaires gra\u0302ce a\u0300 […]<\/p>\n","protected":false},"author":82,"featured_media":10964,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-10965","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nChimie click\u00a0: une chimie qui simplifie la physique, la m\u00e9decine et la biologie - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Cet article est issu du magazine Les Indispensables de Sciences et Avenir n\u00b0216 date\u0301 janvier\/ mars 2024. 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