{"id":11313,"date":"2024-01-19T21:16:13","date_gmt":"2024-01-19T21:16:13","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/la-rapamycine-un-elixir-de-longue-vie-efficace"},"modified":"2024-01-19T22:43:04","modified_gmt":"2024-01-19T22:43:04","slug":"la-rapamycine-un-elixir-de-longue-vie-efficace","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace","title":{"rendered":"La Rapamycine, un \u00c9lixir de Longue Vie Efficace ?"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>La rapamycine est une substance isole\u0301e a\u0300 partir d\u2019une bacte\u0301rie (Streptomyces hygroscopicus) de\u0301couverte pour la premie\u0300re fois dans le sol de Rapa-Nui (l\u2019i\u0302le de Pa\u0302ques). Elle posse\u0300de des proprie\u0301te\u0301s immunosuppressives qui en font l\u2019un des me\u0301dicaments utilise\u0301s pour limiter les risques de rejets en cas de greffe. Mais depuis 2009, et une publication dans la revue Nature, cette substance suscite un incroyable engouement: elle serait en effet capable de combattre la se\u0301nescence et ainsi d\u2019allonger la dure\u0301e de vie moyenne. Un ve\u0301ritable e\u0301lixir de longue vie (et pas de jouvence, la rapamycine peut en effet retarder le vieillissement mais pas l\u2019inverser), a\u0300 manier avec pre\u0301caution.<\/p>\n

Le me\u0301canisme anti-a\u0302ge de la rapamycine<\/b><\/p>\n

Le me\u0301canisme anti-a\u0302ge de la rapamycine est lie\u0301 a\u0300 l\u2019inhibition de la prote\u0301ine mTOR (mammalian Target Of Rapamycin, ou encore, cible de la rapamycine chez les mammife\u0300res). Le blocage de voie mTOR e\u0301tait de\u0301ja\u0300 connu pour prolonger la vie de certaines espe\u0300ces: levure, mouches ou ne\u0301matodes, mais en 2009, il est apparu que la rapamycine est capable d\u2019allonger la dure\u0301e de vie des souris d\u2019environ 15% pour les femelles et d\u2019environ 10% pour les ma\u0302les. Pour la premie\u0300re fois, les me\u0301decins avaient a\u0300 leur disposition une substance me\u0301dicamenteuse capable de ralentir la se\u0301nescence chez les mammife\u0300res. Un Graal pour les scientifiques mais qui n\u2019est pas encore accessible a\u0300 l\u2019humain.<\/p>\n

En effet, une e\u0301tude publie\u0301e en 2012 dans la revue Science indique que le produit n\u2019inhibe pas seulement une prote\u0301ine kinase appele\u0301e mTORC1 pour produire ses effets sur la longe\u0301vite\u0301 mais qu\u2019il brise aussi un complexe apparente\u0301 appele\u0301 mTORC2 et que mTORC2 est ne\u0301cessaire a\u0300 la re\u0301gulation par l\u2019insuline du me\u0301tabolisme du glucose dans le foie. En clair, la prise de rapamycine pourrait induire une re\u0301sistance a\u0300 l\u2019insuline voire un diabe\u0300te de type 2. Aussi, les scientifiques sont a\u0300 la recherche de substances pouvant bloquer plus spe\u0301cifiquement le complexe mTORC1 sans alte\u0301rer mTORC2, ce qui e\u0301viterait les effets secondaires. Des e\u0301tudes sont en cours dont les premiers re\u0301sultats devraient biento\u0302t e\u0302tre disponibles.<\/p>\n

Des e\u0301valuations encourageantes<\/b><\/p>\n

Mais en de\u0301pit du risque suppose\u0301 d\u2019effets secondaires, de nombreuses personnes (la plupart aux Etats-Unis) se voient prescrire de la rapamycine hors AMM, en pre\u0301vention. Une e\u0301tude datant de 2023 a e\u0301value\u0301 son innocuite\u0301 sur 333 personnes en bonne sante\u0301 qui en prenait a\u0300 de faibles doses (plus faibles que pour l\u2019effet immunosuppresseur recherche\u0301 en cas de transplantation). Elle semble montrer que les effets secondaires ne sont pas si importants que cela a\u0300 faible dose mais incluent ne\u0301anmoins un risque plus e\u0301leve\u0301 d\u2019infections bacte\u0301riennes et de plaies buccales. En revanche, la rapamycine a sensiblement ame\u0301liore\u0301 les sympto\u0302mes ressentis de plusieurs maladies, de l\u2019arthrite aux troubles de l\u2019humeur tels que la de\u0301pression en passant par le Covid long.<\/p>\n

Cette e\u0301tude, qui est base\u0301e sur des re\u0301ponses des participants sans e\u0301valuation me\u0301dicale des be\u0301ne\u0301fices et\/ou effets secondaires de\u0301clare\u0301s, ne peut constituer une preuve suffisante ni de l\u2019absence de dangerosite\u0301 de la rapamycine ni de son efficacite\u0301. Toutefois, elle indique que des recherches plus pousse\u0301es sur la sante\u0301 humaine et la se\u0301nescence peuvent e\u0302tre mene\u0301es sans grand danger et d\u2019ailleurs d\u2019autres protocoles d\u2019e\u0301valuation sont pre\u0301vus pour les prochaines anne\u0301es.<\/p>\n

Si la rapamycine semble bel et bien posse\u0301der un potentiel pour ralentir le vieillissement chez l\u2019Homme, d\u2019autres moyens (qui ont eux fait leur preuve) peuvent e\u0301galement e\u0302tre mobilise\u0301s. Ainsi, la pratique d\u2019une activite\u0301 sportive re\u0301gulie\u0300re, les choix alimentaires, l\u2019ame\u0301lioration du sommeil et le maintien des liens sociaux constituent autant d\u2019armes associe\u0301es a\u0300 une meilleure espe\u0301rance de vie en bonne sante\u0301.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. La rapamycine est une substance isole\u0301e a\u0300 partir d\u2019une bacte\u0301rie (Streptomyces hygroscopicus) de\u0301couverte pour la premie\u0300re fois dans le sol de Rapa-Nui (l\u2019i\u0302le de Pa\u0302ques). Elle posse\u0300de des proprie\u0301te\u0301s immunosuppressives qui en font l\u2019un des me\u0301dicaments utilise\u0301s pour limiter les risques de rejets en cas de greffe. Mais depuis […]<\/p>\n","protected":false},"author":82,"featured_media":11312,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-11313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nLa Rapamycine, un \u00c9lixir de Longue Vie Efficace ? - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"La rapamycine est une substance isole\u0301e a\u0300 partir d\u2019une bacte\u0301rie (Streptomyces hygroscopicus) de\u0301couverte pour la premi ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La Rapamycine, un \u00c9lixir de Longue Vie Efficace ?\" \/>\n<meta property=\"og:description\" content=\"La rapamycine est une substance isole\u0301e a\u0300 partir d\u2019une bacte\u0301rie (Streptomyces hygroscopicus) de\u0301couverte pour la premi ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\" \/>\n<meta property=\"og:site_name\" content=\"S\u00e3o Tom\u00e9 e Pr\u00edncipe\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-19T21:16:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-19T22:43:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/sao-tome-e-principe\/sites\/59\/2024\/01\/sm_1705687864.753788.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"899\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"La Rapamycine, un \u00c9lixir de Longue Vie Efficace ?\",\"datePublished\":\"2024-01-19T21:16:13+00:00\",\"dateModified\":\"2024-01-19T22:43:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\"},\"wordCount\":722,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/sao-tome-e-principe\/sites\/59\/2024\/01\/sm_1705687864.753788.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-S\u00e3o Tom\u00e9 e Pr\u00edncipe\",\"S\u00e3o Tom\u00e9 e Pr\u00edncipe\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\",\"url\":\"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/la-rapamycine-un-elixir-de-longue-vie-efficace\",\"name\":\"La Rapamycine, un \u00c9lixir de Longue Vie Efficace ? 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