{"id":12078,"date":"2024-02-23T21:22:51","date_gmt":"2024-02-23T21:22:51","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/des-ultrasons-therapeutiques-face-au-glioblastome"},"modified":"2024-02-23T22:33:34","modified_gmt":"2024-02-23T22:33:34","slug":"des-ultrasons-therapeutiques-face-au-glioblastome","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/des-ultrasons-therapeutiques-face-au-glioblastome","title":{"rendered":"Des ultrasons th\u00e9rapeutiques face au glioblastome"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Le glioblastome est un type de cancer ce\u0301re\u0301bral qui tue environ 3500 personnes par an en France. Il s\u2019agit d\u2019une tumeur de mauvais pronostic, a\u0300 haut risque de re\u0301cidive. Destine\u0301 a\u0300 contrer cette maladie, un essai clinique original \u2013 nomme\u0301 SONOBIRD \u2013 vient de de\u0301marrer.<\/p>\n

Objectif: ouvrir temporairement la barrie\u0300re he\u0301matoence\u0301phalique<\/b><\/p>\n

L\u2019essai international repose sur une technique made in France. Il implique des ultrasons particuliers de faible intensite\u0301 et se de\u0301roulera dans diffe\u0301rents centre, re\u0301partis en Europe et outre-Atlantique.<\/p>\n

En pratique, cet essai de phase 3 randomise\u0301 et multicentrique va tester un dispositif innovant en phase de test depuis de\u0301ja\u0300 quelques anne\u0301es. Sa particularite\u0301: ouvrir temporairement pendant quelques heures la barrie\u0300re he\u0301matoence\u0301phalique (BHE) afin d\u2019ame\u0301liorer le passage des chimiothe\u0301rapies pour leur permettre de mieux diffuser.<\/p>\n

Le dispositif est implante\u0301 au moment de l\u2019intervention chirurgicale quand le chirurgien re\u0301alise une craniotomie, une ouverture du crane permettant d\u2019acce\u0301der au cerveau pour en extraire la tumeur. De premiers essais, dont les re\u0301sultats complets sont attendus au cours de l\u2019anne\u0301e 2024, ont de\u0301ja\u0300 de\u0301montre\u0301 la faisabilite\u0301 et le profil de se\u0301curite\u0301 du dispositif de\u0301veloppe\u0301 sous plusieurs versions.<\/p>\n

560 patients dans les essais cliniques en Europe et aux Etats-Unis<\/b><\/p>\n

Dans tous les cas, sont envoye\u0301s des ultrasons pulse\u0301s de faible intensite\u0301 (Low Intensity Pulsed Ultrasounds, LIPU). Applique\u0301s en combinaison avec l\u2019injection intraveineuse d\u2019un agent constitue\u0301 de microbulles, ils entrai\u0302nent la vibration de ces dernie\u0300res. Et c\u2019est justement cet effet me\u0301canique qui, en perturbant temporairement les jonctions cellulaires serre\u0301es de la BHE, permet d\u2019augmenter sa perme\u0301abilite\u0301 pour favoriser un meilleur passage des mole\u0301cules de chimiothe\u0301rapie.<\/p>\n

SONOBIRD va inclure des patients pre\u0301sentant une re\u0301cidive de leur tumeur ce\u0301re\u0301brale. Cet essai a pour objectif de comparer l\u2019efficacite\u0301 de son dispositif me\u0301dical ultrasonore, SonoCloud-9\u00ae utilise\u0301 avec la chimiothe\u0301rapie dite carboplatine, a\u0300 celle des traitements standards (lomustine, temozolomide) administre\u0301s eux sans ultrasons.<\/p>\n

Carthera, la socie\u0301te\u0301 franc\u0327aise qui a de\u0301veloppe\u0301 SonoCloud, vient tout juste d\u2019annoncer l\u2019inclusion des premiers patients. 560 au total sont pre\u0301vus, tous re\u0301partis en Europe et aux Etats-Unis. Ils seront recrute\u0301s au cours des deux prochaines anne\u0301es, l\u2019e\u0301tude devant elle durer jusqu\u2019en 2028. A suivre.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. Le glioblastome est un type de cancer ce\u0301re\u0301bral qui tue environ 3500 personnes par an en France. Il s\u2019agit d\u2019une tumeur de mauvais pronostic, a\u0300 haut risque de re\u0301cidive. Destine\u0301 a\u0300 contrer cette maladie, un essai clinique original \u2013 nomme\u0301 SONOBIRD \u2013 vient de de\u0301marrer. Objectif: ouvrir temporairement la […]<\/p>\n","protected":false},"author":82,"featured_media":12077,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-12078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nDes ultrasons th\u00e9rapeutiques face au glioblastome - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Le glioblastome est un type de cancer ce\u0301re\u0301bral qui tue environ 3500 personnes par an en France. 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