{"id":12472,"date":"2024-03-15T21:25:12","date_gmt":"2024-03-15T21:25:12","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/sida-un-medicament-anti-obesite-pourrait-ameliorer-la-sante-des-patients"},"modified":"2024-03-16T00:11:12","modified_gmt":"2024-03-16T00:11:12","slug":"sida-un-medicament-anti-obesite-pourrait-ameliorer-la-sante-des-patients","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/sida-un-medicament-anti-obesite-pourrait-ameliorer-la-sante-des-patients","title":{"rendered":"Sida : un m\u00e9dicament anti-ob\u00e9sit\u00e9 pourrait am\u00e9liorer la sant\u00e9 des patients"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Apre\u0300s le diabe\u0300te, l\u2019obe\u0301site\u0301 et les maladies neurode\u0301ge\u0301ne\u0301ratives comme Alzheimer, le GLP-1 pourrait bien ame\u0301liorer la vie des personnes se\u0301ropositives. Cette mole\u0301cule, commercialise\u0301e sous le nom de Wegovy pour l\u2019obe\u0301site\u0301 et Ozempic pour le diabe\u0300te, imite une hormone appele\u0301e le glucagon-like peptide 1. Elle participe a\u0300 la baisse des niveaux de sucre dans le sang et aide a\u0300 contro\u0302ler l\u2019appe\u0301tit. De nouveaux travaux, pre\u0301sente\u0301s de\u0301but mars 2024, semblent e\u0301galement montrer une action positive chez les personnes porteuses du VIH.<\/p>\n

La surcharge de graisse entrai\u0302ne des le\u0301sions dans le foie<\/b><\/p>\n

Tout comme dans la population ge\u0301ne\u0301rale, le nombre de personnes se\u0301ropositives en surpoids devient de plus en plus important. D\u2019autant plus que les the\u0301rapies antire\u0301trovirales ont e\u0301te\u0301 associe\u0301es avec une accumulation anormale de graisse abdominale, ce qui rend les patients se\u0301ropositifs encore plus a\u0300 risque que les autres. Environ 30 a\u0300 40% des personnes porteuses du VIH sont affecte\u0301es par une dysfonction me\u0301tabolique, appele\u0301e la ste\u0301atose he\u0301patique, qui se caracte\u0301rise par une accumulation de graisse dans le foie. Plus la maladie progresse et plus le risque d\u2019insuffisance he\u0301patique et de maladies cardiaques est e\u0301leve\u0301.<\/p>\n

Concre\u0300tement, la surcharge de graisse entrai\u0302ne des le\u0301sions dans le foie, au point de l\u2019empe\u0302cher de fonctionner correctement. Ce qui peut mettre gravement en danger la vie du patient. \u201cOn sait que les personnes se\u0301ropositives pre\u0301sentent des formes de maladie du foie gras plus agressives que les autres\u201d, confirme Jordan Lake, spe\u0301cialise\u0301e dans les maladies infectieuses a\u0300 l\u2019Universite\u0301 du Texas (Etats-Unis), dans la revue Nature.<\/p>\n

Moins de graisse autour du foie et sur l\u2019abdomen<\/b><\/p>\n

Pour l\u2019instant, aucun me\u0301dicament n\u2019a e\u0301te\u0301 approuve\u0301 pour traiter ce proble\u0300me. Mais l\u2019hormone GLP-1 semble e\u0302tre prometteuse. Dans un essai clinique mene\u0301 chez 222 personnes se\u0301ropositives recevant un traitement contre le VIH, l\u2019utilisation de cette mole\u0301cule a e\u0301te\u0301 associe\u0301e avec une perte de poids moyenne de 6,5 kilogrammes sur un an, soit environ 5,7% du poids d\u2019origine des participants.<\/p>\n

Avec une injection toutes les semaines pendant six mois, 29% des patients se sont totalement re\u0301tablis de leur ste\u0301atose he\u0301patique. Une re\u0301duction \u201cimpressionnante et significative en un temps aussi restreint\u201d, se fe\u0301licite le Dr Lake. Seul point ne\u0301gatif: les malades les plus a\u0302ge\u0301s, de 60 ans ou au-dela\u0300, ont montre\u0301 une perte musculaire, ce qui demande un suivi spe\u0301cialise\u0301.<\/p>\n

Au-dela\u0300 du foie, l\u2019hormone semble capable d\u2019e\u0301liminer significativement la graisse abdominale chez les personnes se\u0301ropositives. C\u2019est en tout cas ce que semble montrer un essai mene\u0301 cette fois chez les personnes souffrant de lipohypertrophie, une anomalie de la re\u0301partition du tissu graisseux. \u201cLa graisse abdominale, associe\u0301e a\u0300 une inflammation e\u0301leve\u0301e dans le corps, entrai\u0302ne un risque cardiome\u0301tabolique plus e\u0301leve\u0301\u201d, pre\u0301cise Allison Eckard, de l\u2019Universite\u0301 me\u0301dicale de Caroline du Sud.<\/p>\n

Me\u0302me chez les personnes dont le VIH est bien contro\u0302le\u0301, un e\u0301tat d\u2019inflammation chronique peut s\u2019installer. Cette inflammation peut engendrer toutes sortes de maladies dans les organes, le c\u0153ur, les reins mais aussi le cerveau ou le foie. Pour les participants de cet essai, les marqueurs d\u2019inflammation dans le sang (les prote\u0301ines C re\u0301actives) avaient baisse\u0301 de 40% par rapport aux participants qui n\u2019ont pas eu acce\u0300s a\u0300 la mole\u0301cule.<\/p>\n

Ces donne\u0301es, qui sont pour le moment pre\u0301liminaires, demandent a\u0300 e\u0302tre confirme\u0301es par de futurs essais cliniques plus larges. Mais si GLP-1 venait a\u0300 confirmer son efficacite\u0301 dans ce domaine, il pourrait bien devenir un traitement cle\u0301 dans le contro\u0302le des maladies me\u0301taboliques induites par les me\u0301dicaments antire\u0301troviraux chez les personnes porteuses du VIH.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. Apre\u0300s le diabe\u0300te, l\u2019obe\u0301site\u0301 et les maladies neurode\u0301ge\u0301ne\u0301ratives comme Alzheimer, le GLP-1 pourrait bien ame\u0301liorer la vie des personnes se\u0301ropositives. Cette mole\u0301cule, commercialise\u0301e sous le nom de Wegovy pour l\u2019obe\u0301site\u0301 et Ozempic pour le diabe\u0300te, imite une hormone appele\u0301e le glucagon-like peptide 1. Elle participe a\u0300 la baisse des […]<\/p>\n","protected":false},"author":82,"featured_media":12471,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-12472","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nSida : un m\u00e9dicament anti-ob\u00e9sit\u00e9 pourrait am\u00e9liorer la sant\u00e9 des patients - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Apre\u0300s le diabe\u0300te, l\u2019obe\u0301site\u0301 et les maladies neurode\u0301ge\u0301ne\u0301ratives comme Alzheimer, le GLP-1 pourrait bien ame\u0301liorer ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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