{"id":13097,"date":"2024-04-27T13:43:53","date_gmt":"2024-04-27T13:43:53","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/les-tumeurs-ne-seraient-pas-forcement-induites-par-des-mutations-genetiques"},"modified":"2024-04-27T15:17:59","modified_gmt":"2024-04-27T15:17:59","slug":"les-tumeurs-ne-seraient-pas-forcement-induites-par-des-mutations-genetiques","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/les-tumeurs-ne-seraient-pas-forcement-induites-par-des-mutations-genetiques","title":{"rendered":"Les tumeurs ne seraient pas forc\u00e9ment induites par des mutations g\u00e9n\u00e9tiques"},"content":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Une de\u0301couverte remet en question le ro\u0302le des mutations ge\u0301ne\u0301tiques dans le cancer, sugge\u0301rant que l\u2019e\u0301pige\u0301ne\u0301tique pourrait e\u0302tre a\u0300 l\u2019origine de la maladie. Cela ouvre de nouvelles voies the\u0301rapeutiques et souligne l\u2019importance continue de l\u2019e\u0301tude du ge\u0301nome en cance\u0301rologie.<\/p>\n

L\u2019e\u0301tude du ge\u0301nome n\u2019est pas termine\u0301e. Jusqu\u2019a\u0300 aujourd\u2019hui, on pensait que les mutations ge\u0301ne\u0301tiques e\u0301taient indispensables au processus d\u2019apparition des cancers, l\u2019une des principales causes de mortalite\u0301 dans le monde. Mais une e\u0301quipe de recherche vient de faire une de\u0301couverte majeure remettant en question cette conside\u0301ration, ouvrant ainsi de nouvelles pistes the\u0301rapeutiques en cance\u0301rologie. Et si les cancers trouvaient leur origine dans l\u2019e\u0301pige\u0301ne\u0301tique ?<\/p>\n

L\u2019e\u0301pige\u0301ne\u0301tique a\u0300 l\u2019origine de tumeurs<\/b><\/p>\n

L\u2019e\u0301pige\u0301ne\u0301tique regroupe l\u2019ensemble des modifications de la re\u0301gulation de l\u2019expression des ge\u0300nes. Ce sont elles qui expliquent par exemple pourquoi a\u0300 partir d\u2019un ge\u0301nome identique, un individu peut de\u0301velopper des cellules tre\u0300s varie\u0301es, comme les neurones, les cellules de la peau… Et ce sont e\u0301galement ces modifications qui peuvent induire des cancers, d\u2019apre\u0300s la re\u0301cente de\u0301couverte d\u2019une e\u0301quipe de recherche comprenant des scientifiques du CNRS, publie\u0301e le 24 avril dans la revue Nature.<\/p>\n

Pour en arriver a\u0300 cette conclusion, l\u2019e\u0301quipe de recherche s\u2019est inte\u0301resse\u0301e a\u0300 des facteurs e\u0301pige\u0301ne\u0301tiques pouvant alte\u0301rer l\u2019activite\u0301 des ge\u0300nes chez la drosophile. Ils ont provoque\u0301 un de\u0301re\u0300glement de ces facteurs, puis restaure\u0301 l\u2019e\u0301tat normal des cellules, et ont constate\u0301 qu\u2019une partie du ge\u0301nome restait dysfonctionnelle, induisant un e\u0301tat tumoral persistant, autonome et e\u0301volutif, et gardant en me\u0301moire le statut cance\u0301reux des cellules alors me\u0302me que le signal initiateur e\u0301tait re\u0301pare\u0301.<\/p>\n

Si des e\u0301tudes ont de\u0301ja\u0300 souligne\u0301 l\u2019influence de l\u2019e\u0301pige\u0301ne\u0301tique dans le de\u0301veloppement de tumeurs, c\u2019est la premie\u0300re fois qu\u2019il est de\u0301montre\u0301 que les mutations de l\u2019ADN \u2013 qui s\u2019accumulent au niveau du ge\u0301nome \u2013 ne sont pas indispensables a\u0300 l\u2019apparition des cancers. En d\u2019autres termes, cette de\u0301couverte montre que des processus pas force\u0301ment ge\u0301ne\u0301tiques sont entie\u0300rement capables de provoquer l\u2019apparition et le de\u0301veloppement de tumeur, ouvrant ainsi la voie a\u0300 de nouvelles pistes the\u0301rapeutiques.<\/p>\n

Pour plus d’informations et d’analyses sur la S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – S\u00e3o Tom\u00e9 e Pr\u00edncipe. Une de\u0301couverte remet en question le ro\u0302le des mutations ge\u0301ne\u0301tiques dans le cancer, sugge\u0301rant que l\u2019e\u0301pige\u0301ne\u0301tique pourrait e\u0302tre a\u0300 l\u2019origine de la maladie. Cela ouvre de nouvelles voies the\u0301rapeutiques et souligne l\u2019importance continue de l\u2019e\u0301tude du ge\u0301nome en cance\u0301rologie. L\u2019e\u0301tude du ge\u0301nome n\u2019est pas termine\u0301e. Jusqu\u2019a\u0300 aujourd\u2019hui, on pensait […]<\/p>\n","protected":false},"author":82,"featured_media":13096,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[36,55,56],"class_list":["post-13097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-sao-tome-e-principe","tag-sao-tome-e-principe"],"yoast_head":"\nLes tumeurs ne seraient pas forc\u00e9ment induites par des mutations g\u00e9n\u00e9tiques - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Une de\u0301couverte remet en question le ro\u0302le des mutations ge\u0301ne\u0301tiques dans le cancer, sugge\u0301rant que l\u2019e\u0301pige\u0301ne\u0301tique p ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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