{"id":25015,"date":"2026-02-23T12:00:00","date_gmt":"2026-02-23T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/politique\/vaccin-respiratoire-universel-contre-grippe-covid-allergies"},"modified":"2026-02-24T03:34:38","modified_gmt":"2026-02-24T03:34:38","slug":"vaccin-respiratoire-universel-contre-grippe-covid-allergies","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/sao-tome-e-principe\/toutes-les-actualites\/vaccin-respiratoire-universel-contre-grippe-covid-allergies","title":{"rendered":"Vaccin Respiratoire Universel Contre Grippe Covid Allergies"},"content":{"rendered":"<p><span style=\"color: #ff6600\"><strong>Africa-Press &#8211; S\u00e3o Tom\u00e9 e Pr\u00edncipe. <\/strong><\/span>Il nous prote\u0301gerait de la grippe, du rhume, du Covid-19 et de toutes les maladies respiratoires. Un nouveau vaccin, administre\u0301 sous forme de spray, semble montrer des preuves probantes dans la revue Science. Administre\u0301 a\u0300 la souris pour le moment, le vaccin a montre\u0301 une protection d\u2019au moins trois mois sur de multiples virus, bacte\u0301ries et me\u0302me contre les allerge\u0300nes respiratoires. Si ces re\u0301sultats venaient a\u0300 s\u2019appliquer a\u0300 l\u2019humain, il s\u2019agirait du premier vaccin universel disponible pour se prote\u0301ger des e\u0301pide\u0301mies chaque hiver.<\/p>\n<p>Jusqu\u2019a\u0300 pre\u0301sent, les vaccins sont formule\u0301s de fac\u0327on a\u0300 ce que l\u2019organisme n\u2019apprenne a\u0300 se de\u0301fendre que contre une seule infection. Un principe mis au point par l\u2019Anglais Edward Jenner au 19e sie\u0300cle. Conside\u0301re\u0301 comme le pe\u0300re de l\u2019immunologie, c\u2019est lui qui a mis au point le premier vaccin de l\u2019histoire, celui contre la variole. Le principe est simple: en administrant une partie inoffensive du virus ou de la bacte\u0301rie, le syste\u0300me immunitaire stimule la production d\u2019anticorps et cre\u0301e des \u00ab cellules me\u0301moire \u00bb contre la maladie. En cas d\u2019exposition re\u0301elle, l\u2019organisme peut alors enclencher une re\u0301action rapide et efficace.<\/p>\n<p><b>Le spray nasal, plus fort qu\u2019un vaccin intramusculaire<\/b><\/p>\n<p>Cette fois, l\u2019e\u0301quipe de Stanford a comple\u0300tement inverse\u0301 son raisonnement. Les scientifiques ne font pas le pari d\u2019entrai\u0302ner le syste\u0300me immunitaire contre toutes les maladies hivernales en une fois. Mais ils concentrent leurs efforts sur la fac\u0327on dont les cellules immunitaires communiquent entre elles. \u00ab Le syste\u0300me immunitaire acquis est bien plus ancien d\u2019un point de vue e\u0301volutif \u00bb, explique a\u0300 Sciences et Avenir le Pr Bali Pulendran, spe\u0301cialise\u0301 en immunologie a\u0300 l\u2019Universite\u0301 de Stanford et co-auteur de ces travaux. \u00ab Il est constitue\u0301 de macrophages, de cellules dendritiques, de neutrophiles (tous des globules blancs, ndlr)&#8230; Tous fournissent une protection rapide et large contre diffe\u0301rents microbes. Toutefois, cette re\u0301ponse immunitaire est en ge\u0301ne\u0301ral tre\u0300s courte: elle s\u2019estompe au bout de quelques jours, voire au bout de trois semaines maximum. \u00bb<\/p>\n<p>Pour contourner le proble\u0300me, l\u2019e\u0301quipe a cherche\u0301 a\u0300 activer le syste\u0300me immunitaire directement dans les poumons. Or pour atteindre cet organe, le meilleur chemin reste encore de passer&#8230; par le nez. D\u2019ou\u0300 l\u2019ide\u0301e d\u2019un spray nasal. \u00ab Il est crucial de passer par la voie intranasale. Elle nous permet de cibler directement le syste\u0300me immunitaire des voies ae\u0301riennes et entrai\u0302ne une immunite\u0301 forte et localise\u0301e. Un re\u0301sultat qu\u2019on n\u2019aurait pas pu obtenir en passant par une injection intramusculaire plus conventionnelle \u00bb, poursuit le Pr Pulendran. Car le syste\u0300me immunitaire inne\u0301 est comme \u00ab programme\u0301 \u00bb par chacun de nos tissus \u2013 et non par un agent pathoge\u0300ne global. Ainsi, une fois arrive\u0301 dans les poumons, le vaccin re\u0301ussit a\u0300 maintenir un e\u0301tat immunitaire localise\u0301: les globules blancs, les macrophages, en e\u0301tat d\u2019alerte permanent. En stimulant les macrophages, neutrophiles et cellules dendritiques mentionne\u0301s pre\u0301ce\u0301demment, il permet de ge\u0301ne\u0301rer une re\u0301ponse adaptative dans le poumon, qui s\u2019applique a\u0300 de nombreux virus et bacte\u0301ries respiratoires diffe\u0301rents.<\/p>\n<p><b>Efficace me\u0302me contre les acariens<\/b><\/p>\n<p>Concre\u0300tement, ce spray nasal est compose\u0301 de trois e\u0301le\u0301ments principaux. Deux mole\u0301cules permettant de stimuler les macrophages ainsi que d\u2019autres cellules immunitaires dans les poumons. Ajoute\u0301 a\u0300 cela, un troisie\u0300me composant active les lymphocytes T du syste\u0300me adaptatif. Ces derniers ont pour mission de maintenir le syste\u0300me immunitaire inne\u0301 e\u0301veille\u0301 plus longtemps que la normale. Apre\u0300s quatre doses de spray nasal, les souris ont montre\u0301 une immunite\u0301 contre les coronavirus dont le Covid-19, aux bacte\u0301ries causant des infections respiratoires. Elles ont aussi perdu leur hypersensibilite\u0301 aux acariens.<\/p>\n<p>Mais au-dela\u0300 de ce tour de force, comment le vaccin peut-il aussi diminuer les re\u0301actions allergiques? \u00ab Les infections respiratoires et les allergies impliquent des re\u0301ponses immunitaires dans les me\u0302mes tissus des poumons \u00bb, rappelle le chercheur. C\u2019est ainsi que le spray nasal a aussi permis de supprimer un e\u0301tat d\u2019inflammation allergique pathologique, tout en prote\u0301geant des maladies respiratoires.<\/p>\n<p>Avant de se re\u0301jouir trop vite, reste maintenant a\u0300 retrouver la me\u0302me re\u0301action chez les humains. Chez la souris, cette protection pouvait durer jusqu\u2019a\u0300 plusieurs mois, \u00ab une fraction importante de la vie de l\u2019animal. \u00bb Ce re\u0301sultat laisse espe\u0301rer que l\u2019immunite\u0301 chez l\u2019humain durerait plus longtemps encore \u00ab et que des boosters re\u0301guliers ne seraient pas ne\u0301cessaires. \u00bb Une question a\u0300 laquelle il n\u2019existe aucune re\u0301ponse, avant les re\u0301sultats d\u2019un essai clinique grandeur nature.<\/p>\n<p><strong>Pour plus d&rsquo;informations et d&rsquo;analyses sur la <span style=\"color: #ff6600\">S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/span>, suivez <span style=\"color: #ff6600\">Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Africa-Press &#8211; S\u00e3o Tom\u00e9 e Pr\u00edncipe. Il nous prote\u0301gerait de la grippe, du rhume, du Covid-19 et de toutes les maladies respiratoires. Un nouveau vaccin, administre\u0301 sous forme de spray, semble montrer des preuves probantes dans la revue Science. Administre\u0301 a\u0300 la souris pour le moment, le vaccin a montre\u0301 une protection d\u2019au moins trois [&hellip;]<\/p>\n","protected":false},"author":82,"featured_media":25014,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[56],"class_list":["post-25015","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-sao-tome-e-principe"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vaccin Respiratoire Universel Contre Grippe Covid Allergies - S\u00e3o Tom\u00e9 e Pr\u00edncipe<\/title>\n<meta name=\"description\" content=\"Il nous prote\u0301gerait de la grippe, du rhume, du Covid-19 et de toutes les maladies respiratoires. 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