{"id":62257,"date":"2024-10-26T12:00:00","date_gmt":"2024-10-26T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/impliquee-dans-la-maladie-dalzheimer-la-proteine-tau-peut-aussi-proteger-notre-cerveau"},"modified":"2024-10-26T23:43:48","modified_gmt":"2024-10-26T23:43:48","slug":"impliquee-dans-la-maladie-dalzheimer-la-proteine-tau-peut-aussi-proteger-notre-cerveau","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/impliquee-dans-la-maladie-dalzheimer-la-proteine-tau-peut-aussi-proteger-notre-cerveau","title":{"rendered":"Impliqu\u00e9e dans la maladie d\u2019Alzheimer, la prot\u00e9ine tau peut aussi prot\u00e9ger notre cerveau !"},"content":{"rendered":"

Africa-Press – Senegal. <\/strong><\/span>On sait de\u0301ja\u0300 que la prote\u0301ine tau est indispensable au bon fonctionnement du cerveau\u201d, pose Florence Clavaguera, chercheuse a\u0300 l\u2019Institut du Cerveau a\u0300 Paris et spe\u0301cialiste de la prote\u0301ine tau. Mais re\u0301cemment, d\u2019autres neurobiologistes ont mis en lumie\u0300re un me\u0301canisme de protection assure\u0301 par la prote\u0301ine, plus connue dans la maladie d\u2019Alzheimer que pour ses proprie\u0301te\u0301s be\u0301ne\u0301fiques.<\/p>\n

Pourtant, en introduisant la version pathologique de la prote\u0301ine tau \u2013 responsable entre autres de son accumulation caracte\u0301ristique dans la maladie d\u2019Alzheimer \u2013 dans les ge\u0300nes de drosophiles en laboratoire, ces chercheurs ont de\u0301montre\u0301 que lorsque la prote\u0301ine est \u201cabi\u0302me\u0301e\u201d, son ro\u0302le protecteur est diminue\u0301. Mais de quel ro\u0302le parle-t-on ?<\/p>\n

Des de\u0301chets produits par le cerveau<\/b><\/p>\n

Comme dans toute machinerie, il y a des de\u0301chets. Et les cellules du corps ne de\u0301rogent pas a\u0300 cette re\u0300gle. Des de\u0301chets naturels sont produits et peuvent dans certains cas devenir toxiques pour l\u2019organisme en cre\u0301ant un stress oxydatif, par ailleurs associe\u0301 aux maladies neurode\u0301ge\u0301ne\u0301ratives.<\/p>\n

Une piste pour limiter la neurode\u0301ge\u0301ne\u0301ration<\/b><\/p>\n

Fort heureusement, les cellules de soutien des neurones, les astrocytes \u2013 des cellules gliales-, recyclent ces de\u0301chets pour en faire de l\u2019e\u0301nergie. Mais c\u2019est la prote\u0301ine tau qui facilite l\u2019enveloppement et le transport de ces toxines au sein de gouttelettes de lipides vers les cellules gliales.<\/p>\n

\u201cSi la mutation pathologique de tau agit sur d\u2019autres cascades qu\u2019on parvenait a\u0300 identifier, on pourrait limiter le processus de neurode\u0301ge\u0301ne\u0301ration. Sans jouer directement sur la prote\u0301ine tau, on pourrait trouver des solutions pour restaurer la fonction de protection des astrocytes\u201d, imagine Florence Clavaguera. Affaire a\u0300 suivre donc, notamment par des expe\u0301riences sur des souris transge\u0301niques.<\/p>\n

Plus d\u2019informations a\u0300 propos de cette de\u0301couverte sont a\u0300 de\u0301couvrir dans un article de\u0301die\u0301 sur le site de La Recherche.<\/p>\n

Pour plus d’informations et d’analyses sur la Senegal, suivez Africa-Press<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Senegal. On sait de\u0301ja\u0300 que la prote\u0301ine tau est indispensable au bon fonctionnement du cerveau\u201d, pose Florence Clavaguera, chercheuse a\u0300 l\u2019Institut du Cerveau a\u0300 Paris et spe\u0301cialiste de la prote\u0301ine tau. Mais re\u0301cemment, d\u2019autres neurobiologistes ont mis en lumie\u0300re un me\u0301canisme de protection assure\u0301 par la prote\u0301ine, plus connue dans la maladie d\u2019Alzheimer […]<\/p>\n","protected":false},"author":82,"featured_media":62256,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-62257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"\nImpliqu\u00e9e dans la maladie d\u2019Alzheimer, la prot\u00e9ine tau peut aussi prot\u00e9ger notre cerveau ! - Senegal<\/title>\n<meta name=\"description\" content=\"On sait de\u0301ja\u0300 que la prote\u0301ine tau est indispensable au bon fonctionnement du cerveau\u201d, pose Florence Clavaguera, cherc ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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