{"id":68850,"date":"2025-06-03T12:00:00","date_gmt":"2025-06-03T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang"},"modified":"2025-06-04T00:22:50","modified_gmt":"2025-06-04T00:22:50","slug":"detection-des-cancers-du-sein-pharmaco-resistants-par-sang","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang","title":{"rendered":"D\u00e9tection des Cancers du Sein Pharmaco-R\u00e9sistants par Sang"},"content":{"rendered":"

Africa-Press – Senegal. <\/strong><\/span>Comment repe\u0301rer au plus to\u0302t l\u2019e\u0301chappement d\u2019une tumeur (ici des cancers du sein hormono-de\u0301pendants me\u0301tastase\u0301s) en de\u0301tectant l\u2019apparition de nouvelles mutations? En dosant re\u0301gulie\u0300rement l\u2019ADN tumoral circulant (ADNtc) avec une simple prise de sang. Tel est le concept ne\u0301 a\u0300 l\u2019Institut Curie il y a plusieurs anne\u0301es et qui voit son aboutissement tout juste pre\u0301sente\u0301 en se\u0301ance ple\u0301nie\u0300re (une tre\u0300s importante distinction parmi plus de 5.000 communications) lors de la 61e e\u0301dition 2025 du congre\u0300s international du cancer (ASCO), qui re\u0301unit du 30 mai au 4 juin a\u0300 Chicago (E\u0301tats-Unis) pre\u0300s de 40.000 spe\u0301cialistes internationaux.<\/p>\n

Ce travail, l\u2019essai Serena- 6, marque incontestablement une e\u0301tape importante dans la prise en charge des tumeurs du sein. Il s\u2019agit la\u0300 du premier essai mondial de phase 3 a\u0300 utiliser une approche guide\u0301e par l\u2019ADNtc pour de\u0301tecter l\u2019e\u0301mergence d\u2019une re\u0301sistance de la tumeur au traitement. Dans ce type de cancers du sein les plus fre\u0301quents (65%), dits hormono-de\u0301pendants me\u0301tastatiques , \u00bbmoins de 5% des femmes pre\u0301sentent une mutation du re\u0301cepteur aux \u0153stroge\u0300nes (ESR1) avant le de\u0301but du traitement \u00bb, pre\u0301cise le Pr Franc\u0327ois-Cle\u0301ment Bidard, oncologue me\u0301dical a\u0300 l\u2019Institut Curie (Paris) et copilote de ce travail mondial. \u00ab Par contre, quand la maladie e\u0301volue, on sait que cette mutation est alors retrouve\u0301e chez 40% des femmes \u00bb.<\/p>\n

Eclairer plus to\u0302t la de\u0301cision de changer de traitement<\/b><\/p>\n

D\u2019ou\u0300 l\u2019ide\u0301e d\u2019identifier au plus to\u0302t le moment de leur apparition. Car cette mutation s\u2019ave\u0300re de\u0301tectable dans le sang par une simple prise de sang, de\u0301tectant ici l\u2019ADN relargue\u0301 par les cellules tumorales. Mais attention, a\u0300 ce stade des recherches, cette technique n\u2019est pas encore utilisable sur un plan diagnostique mais employe\u0301e strictement pour surveiller l\u2019e\u0301chappement aux traitements.<\/p>\n

Franc\u0327ois-Cle\u0301ment Bidard, qui travaille de longue date sur le sujet en collaboration avec le re\u0301seau Unicancer, avait de\u0301ja\u0300 rapporte\u0301 cette approche en 2022 dans un essai acade\u0301mique dit PADA -1. Il avait alors de\u0301montre\u0301 que des prises de sang re\u0301alise\u0301es tous les deux mois permettaient de de\u0301tecter la mutation avant que celle-ci ne se traduise radiologiquement par une augmentation de la taille de la tumeur, qui, justement en raison de cette mutation, devient alors insensible au traitement, un peu comme avec le phe\u0301nome\u0300ne d\u2019antibiore\u0301sistance de\u0301veloppe\u0301e par les bacte\u0301ries.<\/p>\n

C\u2019est la\u0300 que la surveillance rapproche\u0301e biologique de\u0301passe celle assure\u0301e par l\u2019imagerie, en permettant d\u2019e\u0301clairer plus to\u0302t la de\u0301cision de changer de traitement, avant que la progression de la maladie ne soit visible sur les scanners, effectue\u0301s environ tous les 3 a\u0300 4 mois.<\/p>\n

Une solution plus simple et aussi moins cou\u0302teuse. Or, depuis la pre\u0301sentation de ce concept, le laboratoire AstraZeneca a propose\u0301 de l\u2019appliquer a\u0300 sa nouvelle hormonothe\u0301rapie contre le cancer du sein, le camizestrant, une mole\u0301cule d\u2019une nouvelle classe d\u2019hormonothe\u0301rapie appele\u0301e les SERD.<\/p>\n

Et dans l\u2019essai pre\u0301sente\u0301 cette anne\u0301e a\u0300 l\u2019Asco, deux groupes d\u2019environ 150 femmes portant la mutation ESR1 et recevant le traitement standard, une anti-aromatase combine\u0301e a\u0300 un inhibiteur de la prolife\u0301ration cellulaire CDK4\/6, ont e\u0301te\u0301 suivis avec une prise de sang tous les 2 a\u0300 3 mois. Si le groupe standard a continue\u0301 le me\u0302me traitement sans modification, le groupe expe\u0301rimental a lui vu son hormonothe\u0301rapie modifie\u0301e et a rec\u0327u le nouveau SERD.<\/p>\n

La biologie de\u0301passe ici la radiologie<\/b><\/p>\n

Au-dela\u0300 de la bonne tole\u0301rance au traitement, l\u2019essai de\u0301montre que pour les femmes du groupe expe\u0301rimental le risque d\u2019e\u0301volution tumorale a diminue\u0301 de 56%, leur taux de survie sans progression de la tumeur a\u0300 12 mois atteignant 60,7 % contre 33,4 % pour le groupe standard. \u201cDe plus, on retarde ici l\u2019e\u0301volution de la tumeur tout en pre\u0301servant la qualite\u0301 de vie des femmes\u201d, insiste le spe\u0301cialiste. En effet, l\u2019analyse des questionnaires des patientes a montre\u0301 que cette qualite\u0301 de vie de\u0301clinait environ vingt trois mois apre\u0300s la modification de traitement contre six mois pour celles reste\u0301es sous traitement standard malgre\u0301 la pre\u0301sence de la mutation.<\/p>\n

Bonne nouvelle: \u00ab Ces techniques de PCR qui n\u2019ont rien d\u2019e\u0301litiste sont simples et surtout de\u0301ja\u0300 accessibles en pratique, les plateformes de biologie mole\u0301culaire existant soit en interne dans les centres anticancer les plus importants, soit en externe pour les autres, pre\u0301cise l\u2019oncologue. Restera toutefois a\u0300 re\u0301gler la question de leur remboursement, d\u2019autant que le volume des tests pratique\u0301s est amene\u0301 a\u0300 rapidement augmenter \u00bb.<\/p>\n

Changement donc de paradigme a\u0300 venir dans la surveillance de l\u2019e\u0301volution des cancers du sein, la biologie de\u0301passant ici la radiologie. \u00ab Une surveillance par prise de sang environ tous les 4 mois devrait a\u0300 terme convenir, estime l\u2019oncologue, pour environ plusieurs milliers de nouvelles patientes par an en France.<\/p>\n

Nul doute que, tre\u0300s rapidement, cette surveillance biologique be\u0301ne\u0301ficie a\u0300 d\u2019autres cancers que ceux du sein. Gagner du temps contre le cancer, quelle que soit sa localisation, est un combat permanent.<\/p>\n

Pour plus d’informations et d’analyses sur la Senegal<\/span>, suivez Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Senegal. Comment repe\u0301rer au plus to\u0302t l\u2019e\u0301chappement d\u2019une tumeur (ici des cancers du sein hormono-de\u0301pendants me\u0301tastase\u0301s) en de\u0301tectant l\u2019apparition de nouvelles mutations? En dosant re\u0301gulie\u0300rement l\u2019ADN tumoral circulant (ADNtc) avec une simple prise de sang. Tel est le concept ne\u0301 a\u0300 l\u2019Institut Curie il y a plusieurs anne\u0301es et qui voit son aboutissement […]<\/p>\n","protected":false},"author":82,"featured_media":68849,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-68850","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"\nD\u00e9tection des Cancers du Sein Pharmaco-R\u00e9sistants par Sang - Senegal<\/title>\n<meta name=\"description\" content=\"Comment repe\u0301rer au plus to\u0302t l\u2019e\u0301chappement d\u2019une tumeur (ici des cancers du sein hormono-de\u0301pendants me\u0301tastase\u0301s) en ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9tection des Cancers du Sein Pharmaco-R\u00e9sistants par Sang\" \/>\n<meta property=\"og:description\" content=\"Comment repe\u0301rer au plus to\u0302t l\u2019e\u0301chappement d\u2019une tumeur (ici des cancers du sein hormono-de\u0301pendants me\u0301tastase\u0301s) en ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\" \/>\n<meta property=\"og:site_name\" content=\"Senegal\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-03T12:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-04T00:22:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/06\/sm_1749025061.011469.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"899\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"D\u00e9tection des Cancers du Sein Pharmaco-R\u00e9sistants par Sang\",\"datePublished\":\"2025-06-03T12:00:00+00:00\",\"dateModified\":\"2025-06-04T00:22:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\"},\"wordCount\":927,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/06\/sm_1749025061.011469.jpg\",\"keywords\":[\"Senegal\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\",\"url\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/detection-des-cancers-du-sein-pharmaco-resistants-par-sang\",\"name\":\"D\u00e9tection des Cancers du Sein Pharmaco-R\u00e9sistants par Sang - 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