{"id":69702,"date":"2025-07-08T12:00:00","date_gmt":"2025-07-08T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/fertilite-feminine-perturbee-par-horaires-decales"},"modified":"2025-07-09T01:22:04","modified_gmt":"2025-07-09T01:22:04","slug":"fertilite-feminine-perturbee-par-horaires-decales","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales","title":{"rendered":"Fertilit\u00e9 F\u00e9minine Perturb\u00e9e par Horaires D\u00e9cal\u00e9s"},"content":{"rendered":"

Africa-Press – Senegal. <\/strong><\/span>Chez les femmes, le respect du rythme circadien a probablement un impact sur la fertilite\u0301, explique Vale\u0301rie Simonneaux, directrice de recherche au CNRS a\u0300 l\u2019Institut des Neurosciences Cellulaires et Inte\u0301gratives (INCI), lors des Journe\u0301es Internationales d\u2019Endocrinologie de juin 2025. C\u2019est en tout cas ce que tendent a\u0300 montrer de nombreux travaux re\u0301alise\u0301s sur les souris, et qu\u2019une e\u0301tude clinique en pre\u0301paration ambitionne de montrer chez l\u2019humain. En particulier, le travail en horaires de\u0301cale\u0301s et irre\u0301guliers pourrait affecter les hormones sexuelles fe\u0301minines et le risque de troubles de la fertilite\u0301.<\/p>\n

Le pic de LH, indicateur de la synchronisation du cycle menstruel<\/b><\/p>\n

\u00ab Quasiment tous les ge\u0300nes exprime\u0301s dans les ovaires ont des rythmes journaliers. Celui des re\u0301cepteurs a\u0300 la LH par exemple s\u2019exprime de fac\u0327on a\u0300 ce qu\u2019il y ait un maximum de re\u0301cepteurs au moment du pic de LH \u00bb, illustre Vale\u0301rie Simonneaux. Ce pic de LH, ou hormone lute\u0301inisante, est essentiel pour induire l\u2019ovulation au milieu du cycle menstruel. De\u0301clenche\u0301 par l\u2019hypothalamus \u2013 une structure ce\u0301re\u0301brale a\u0300 la base du cerveau \u2013 de tous les mammife\u0300res femelles, ce pic pre\u0301ovulatoire se produit toujours a\u0300 un moment dicte\u0301 par le rythme circadien. Plus pre\u0301cise\u0301ment, ce pic a lieu a\u0300 la transition entre la pe\u0301riode de repos et d\u2019activite\u0301, c\u2019est-a\u0300-dire la fin de nuit pour les femmes ou a\u0300 la tombe\u0301e du jour pour les souris femelles, espe\u0300ce nocturne. \u00ab Pour que l\u2019organisme soit en phase avec l\u2019environnement, les neurones des noyaux suprachiasmatiques, ge\u0301rant l\u2019horloge biologique dans l\u2019hypothalamus, sont tre\u0300s sensibles a\u0300 la lumie\u0300re de\u0301tecte\u0301e par la re\u0301tine \u00bb, de\u0301taille Vale\u0301rie Simonneaux.<\/p>\n

Exposer a\u0300 re\u0301pe\u0301tition la re\u0301tine a\u0300 la lumie\u0300re pendant la nuit de\u0301synchronise donc l\u2019horloge et toutes les fonctions biologiques qui en de\u0301coulent. Chez les souris expose\u0301es a\u0300 la lumie\u0300re plusieurs heures en avance, le pic de LH est avance\u0301. \u00ab On cre\u0301e comme un jetlag en avanc\u0327ant l\u2019heure de la journe\u0301e de quelques heures. Le pic mettra ensuite une quinzaine de jours a\u0300 se resynchroniser une fois le rythme initial re\u0301instaure\u0301 \u00bb, relate Vale\u0301rie Simonneaux. Un temps qui correspond a\u0300 trois cycles ovariens chez les souris.<\/p>\n

Les horaires \u00ab poste\u0301s rotatifs \u00bb sont les plus susceptibles d\u2019affecter la fertilite\u0301 fe\u0301minine<\/b><\/p>\n

C\u2019est lorsque l\u2019exposition a\u0300 la lumie\u0300re est irre\u0301gulie\u0300re que les perturbations deviennent majeures chez les souris femelles, avec une quasi disparition du pic de LH. Si l\u2019ovulation en elle-me\u0302me n\u2019a pas pu e\u0302tre observe\u0301e, la chercheuse rapporte une baisse de la fertilite\u0301 visible notamment par un retard et une re\u0301duction du nombre de gestations. \u00ab Ce n\u2019est pas une abolition totale mais une re\u0301duction de la fertilite\u0301 \u00bb, pre\u0301cise Vale\u0301rie Simonneaux. Les horaires changeants, dits \u00ab poste\u0301s rotatifs \u00bb, sont donc plus perturbants chez la souris que les horaires de\u0301cale\u0301s mais constants, ajoute-t-elle. Chez les humains, les femmes aux horaires poste\u0301s rotatifs, comme chez le personnel hospitalier, seraient donc potentiellement plus expose\u0301es a\u0300 des perturbations de la fertilite\u0301. C\u2019est ce qu\u2019ambitionne d\u2019e\u0301valuer l\u2019e\u0301tude de Vale\u0301rie Simonneaux et du CHU de Strasbourg, qui pre\u0301voit de suivre le pic de LH de 30 a\u0300 40 femmes ayant des horaires de travail normaux ou poste\u0301s. \u00ab C\u0327a n\u2019a encore jamais e\u0301te\u0301 montre\u0301, mais certaines e\u0301tudes e\u0301pide\u0301miologiques ont releve\u0301 des cycles menstruels irre\u0301guliers, allonge\u0301s ou raccourcis et des concentrations hormonales alte\u0301re\u0301es. \u00bb<\/p>\n

Outre l\u2019augmentation de l\u2019a\u0302ge lors de la conception ou des perturbations me\u0301taboliques, l\u2019environnement a aussi une influence sur la baisse de la fertilite\u0301 fe\u0301minine, avance Vale\u0301rie Simonneaux. \u00ab Peut-e\u0302tre faudra-t-il recommander aux femmes qui essaient de concevoir de surveiller l\u2019exposition a\u0300 la lumie\u0300re et les horaires changeants. \u00bb Les techniques de PMA pourraient e\u0301galement be\u0301ne\u0301ficier d\u2019une prise en compte de l\u2019horaire. \u00ab Ces me\u0301decins font une stimulation ovarienne toujours au me\u0302me moment, mais ne pensent pas force\u0301ment a\u0300 tester diffe\u0301rents horaires pour optimiser le pre\u0301le\u0300vement des ovules ou injecter les spermatozoi\u0308des par exemple \u00bb, conclut Vale\u0301rie Simonneaux.<\/p>\n

Pour plus d’informations et d’analyses sur la Senegal<\/span>, suivez Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Senegal. Chez les femmes, le respect du rythme circadien a probablement un impact sur la fertilite\u0301, explique Vale\u0301rie Simonneaux, directrice de recherche au CNRS a\u0300 l\u2019Institut des Neurosciences Cellulaires et Inte\u0301gratives (INCI), lors des Journe\u0301es Internationales d\u2019Endocrinologie de juin 2025. C\u2019est en tout cas ce que tendent a\u0300 montrer de nombreux travaux re\u0301alise\u0301s […]<\/p>\n","protected":false},"author":82,"featured_media":69701,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-69702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"\nFertilit\u00e9 F\u00e9minine Perturb\u00e9e par Horaires D\u00e9cal\u00e9s - Senegal<\/title>\n<meta name=\"description\" content=\"Chez les femmes, le respect du rythme circadien a probablement un impact sur la fertilite\u0301, explique Vale\u0301rie Simonneaux ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fertilit\u00e9 F\u00e9minine Perturb\u00e9e par Horaires D\u00e9cal\u00e9s\" \/>\n<meta property=\"og:description\" content=\"Chez les femmes, le respect du rythme circadien a probablement un impact sur la fertilite\u0301, explique Vale\u0301rie Simonneaux ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\" \/>\n<meta property=\"og:site_name\" content=\"Senegal\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-08T12:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-09T01:22:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/07\/sm_1752052362.657987.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"899\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Fertilit\u00e9 F\u00e9minine Perturb\u00e9e par Horaires D\u00e9cal\u00e9s\",\"datePublished\":\"2025-07-08T12:00:00+00:00\",\"dateModified\":\"2025-07-09T01:22:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\"},\"wordCount\":770,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/07\/sm_1752052362.657987.jpg\",\"keywords\":[\"Senegal\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\",\"url\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/fertilite-feminine-perturbee-par-horaires-decales\",\"name\":\"Fertilit\u00e9 F\u00e9minine Perturb\u00e9e par Horaires D\u00e9cal\u00e9s - 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