{"id":70420,"date":"2025-08-05T12:00:00","date_gmt":"2025-08-05T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/dentisterie-vers-la-repousse-des-dents-naturelles"},"modified":"2025-08-05T22:56:04","modified_gmt":"2025-08-05T22:56:04","slug":"dentisterie-vers-la-repousse-des-dents-naturelles","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/dentisterie-vers-la-repousse-des-dents-naturelles","title":{"rendered":"Dentisterie: vers la Repousse des Dents Naturelles"},"content":{"rendered":"<p><span style=\"color: #ff6600\"><strong>Africa-Press &#8211; Senegal. <\/strong><\/span>Les scientifiques ouvrent la voie a\u0300 une e\u0301volution majeure: la re\u0301ge\u0301ne\u0301ration des dents naturelles. Un changement qui pourrait, d\u2019ici a\u0300 quelques anne\u0301es, rele\u0301guer implants et dentiers au rang de souvenirs du passe\u0301.<\/p>\n<p>A\u0300 travers le monde, la perte de dents est courante, principalement due aux caries ou a\u0300 des accidents. Aujourd\u2019hui, 7 % des plus de 20 ans \u2013et jusqu\u2019a\u0300 23 % des seniors\u2013 n\u2019ont plus aucune dent naturelle. Le remplacement s\u2019est modernise\u0301 depuis les prothe\u0300ses des E\u0301trusques, mais les implants me\u0301talliques restent la re\u0301fe\u0301rence, bien qu\u2019ils pre\u0301sentent des failles: absence de sensation, inconfort et risques d\u2019inflammation avec le temps. Qui n\u2019a jamais re\u0302ve\u0301 d\u2019une solution vivante, indolore et durable?<\/p>\n<p>L\u2019ide\u0301e de re\u0301ge\u0301ne\u0301rer une dent et non simplement de la remplacer a\u0300 e\u0301merger il y a une vingtaine d\u2019anne\u0301es avec le biologiste londonien Paul Sharpe. Depuis, plusieurs e\u0301quipes dans le monde s\u2019attachent a\u0300 rendre ce re\u0302ve possible, raconte New Scientist. A\u0300 l\u2019universite\u0301 Tufts, a\u0300 Boston (E\u0301tats-Unis), l\u2019orthodontiste Pamela Yelick et son e\u0301quipe ont expe\u0301rimente\u0301 l\u2019implantation de cellules dentaires de porc sur des matrices inse\u0301re\u0301es dans la bouche de rats. Re\u0301sultat: apre\u0300s quelques semaines, de ve\u0301ritables dents, compose\u0301es de dentine et d\u2019e\u0301mail, se sont de\u0301veloppe\u0301es. Reproduire tous les de\u0301tails architecturaux et fonctionnels d\u2019une dent humaine reste cependant ardu.<\/p>\n<p>De son co\u0302te\u0301, Paul Sharpe s\u2019est penche\u0301 avec son e\u0301quipe sur le signalement chimique entre cellules adultes, pour tenter de leur faire rejouer le programme embryonnaire de fabrication dentaire. Les re\u0301sultats de laboratoire sont prometteurs, mais pas encore pre\u0302ts pour la clinique.<\/p>\n<p><b>Cellules, ge\u0300nes et manipulations<\/b><\/p>\n<p>La prouesse tient a\u0300 un ballet complexe entre deux types de cellules: les cellules e\u0301pithe\u0301liales (qui cre\u0301ent l\u2019e\u0301mail) et les me\u0301senchymateuses (a\u0300 l\u2019origine de la dentine et de la pulpe). Si les premie\u0300res ne sont quasiment pre\u0301sentes que chez l\u2019enfant, la technologie des cellules souches induites (iPSC), qui fait \u00ab revenir en arrie\u0300re \u00bb des cellules adultes, offre une piste malgre\u0301 son cou\u0302t e\u0301leve\u0301, aujourd\u2019hui prohibitif compare\u0301 a\u0300 un implant classique.<\/p>\n<p>Certaines e\u0301quipes s\u2019inspirent e\u0301galement de la ge\u0301ne\u0301tique rare. Par exemple, les personnes atteintes de dysplasie cle\u0301ido-cra\u0302nienne (maladie ge\u0301ne\u0301tique affectant les os et les dents) de\u0301veloppent parfois des dents en trop, a\u0300 cause d\u2019un de\u0301faut du ge\u0300ne RUNX2. Des chercheurs japonais ont me\u0302me re\u0301ussi a\u0300 de\u0301clencher la pousse de dents chez la souris en bloquant un autre ge\u0300ne (USAG-1) via des anticorps. Une premie\u0300re mondiale qui a abouti en 2024 au lancement d\u2019essais cliniques sur l\u2019homme.<\/p>\n<p>Si la croissance d\u2019une dent vivante en laboratoire n\u2019a encore donne\u0301 lieu a\u0300 aucune souris \u2013et encore moins e\u0302tre humain\u2013 au sourire avec dents de rechange, l\u2019optimisme reste de mise. La socie\u0301te\u0301 Toregem Biopharma, cre\u0301e\u0301e par Katsu Takahashi et ses colle\u0300gues de l\u2019Universite\u0301 de Kyoto au Japon, espe\u0300re commercialiser un me\u0301dicament favorisant la re\u0301ge\u0301ne\u0301ration dentaire d\u2019ici a\u0300 2030, notamment pour les enfants souffrant d\u2019e\u0301dentation conge\u0301nitale.<\/p>\n<p>Les obstacles techniques pour faire repousser des dents sont de\u0301sormais quasiment leve\u0301s, mais le principal frein reste le manque de financement. Paul Sharpe redoute que cette avance\u0301e ne se concre\u0301tise pas, faute d\u2019inte\u0301re\u0302t de la part de financiers, d\u2019industries pharmaceutiques et d\u2019investisseurs. Malgre\u0301 les re\u0301sultats prometteurs, l\u2019absence de soutien e\u0301conomique empe\u0302che encore les essais cliniques humains a\u0300 grande e\u0301chelle et retarde la commercialisation de ces solutions innovantes.<\/p>\n<p>Biento\u0302t peut-e\u0302tre, remplacer ses dents pourrait ne plus signifier poser du me\u0301tal mais faire refleurir d\u2019e\u0301mail. Un futur ou\u0300 le sourire ne s\u2019ache\u0300tera plus en kit, mais se re\u0301ge\u0301ne\u0300rera naturellement.<\/p>\n<p><strong>Pour plus d&rsquo;informations et d&rsquo;analyses sur la <span style=\"color: #ff6600\">Senegal<\/span>, suivez <span style=\"color: #ff6600\">Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Africa-Press &#8211; Senegal. Les scientifiques ouvrent la voie a\u0300 une e\u0301volution majeure: la re\u0301ge\u0301ne\u0301ration des dents naturelles. Un changement qui pourrait, d\u2019ici a\u0300 quelques anne\u0301es, rele\u0301guer implants et dentiers au rang de souvenirs du passe\u0301. A\u0300 travers le monde, la perte de dents est courante, principalement due aux caries ou a\u0300 des accidents. Aujourd\u2019hui, 7 [&hellip;]<\/p>\n","protected":false},"author":82,"featured_media":70419,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-70420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dentisterie: vers la Repousse des Dents Naturelles - Senegal<\/title>\n<meta name=\"description\" content=\"Les scientifiques ouvrent la voie a\u0300 une e\u0301volution majeure: la re\u0301ge\u0301ne\u0301ration des dents naturelles. 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