{"id":72932,"date":"2025-11-25T12:00:00","date_gmt":"2025-11-25T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/augmentation-des-mutations-deleteres-des-spermatozoides"},"modified":"2025-11-26T04:25:37","modified_gmt":"2025-11-26T04:25:37","slug":"augmentation-des-mutations-deleteres-des-spermatozoides","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides","title":{"rendered":"Augmentation des Mutations D\u00e9l\u00e9t\u00e8res des Spermatozo\u00efdes"},"content":{"rendered":"

Africa-Press – Senegal. <\/strong><\/span>Chaque jour, environ 200 millions de spermatozoi\u0308des sont produits par les testicules chez l\u2019homme et cette intense prolife\u0301ration cellulaire les expose a\u0300 des erreurs de copie de leur ADN causant des mutations. Une premie\u0300re e\u0301tude de la se\u0301quence de l\u2019ADN des spermatozoi\u0308des effectue\u0301e par des chercheurs du Wellcome Sanger Institute au Royaume-Uni, et publie\u0301e dans la revue Nature, re\u0301ve\u0300le que la part des spermatozoi\u0308des mute\u0301s augmente avec l\u2019a\u0302ge et explique pourquoi.<\/p>\n

Une mutation qui peut de\u0301passer 3% des spermatozoi\u0308des a\u0300 partir de 50 ans<\/b><\/p>\n

Les ge\u0301ne\u0301ticiens britanniques ont utilise\u0301 une technologie de se\u0301quenc\u0327age de haute pre\u0301cision et ultrasensible pour se\u0301quencer l\u2019ADN de spermatozoi\u0308des individuels. Ils montrent que la proportion de ceux porteurs d\u2019une mutation retrouve\u0301e dans une maladie ge\u0301ne\u0301tique du de\u0301veloppement ou un cancer est multiplie\u0301e par deux entre 30 et 70 ans.<\/p>\n

Cette proportion, qui peut de\u0301passer 3% des spermatozoi\u0308des a\u0300 partir de 50 ans, a surpris les chercheurs par son importance et explique le risque croissant de maladie ge\u0301ne\u0301tique ou de cancer chez l\u2019enfant observe\u0301 avec l\u2019a\u0302ge du pe\u0300re. Ce risque est ne\u0301anmoins atte\u0301nue\u0301 par le fait que les mutations de\u0301cele\u0301es ne permettront pas toujours le de\u0301veloppement et la naissance d\u2019un enfant. La fre\u0301quence des mutations dans les spermatozoi\u0308des reste aussi largement infe\u0301rieure a\u0300 celle observe\u0301e dans les autres tissus de l\u2019organisme gra\u0302ce a\u0300 un me\u0301canisme protecteur qui reste a\u0300 e\u0301lucider.<\/p>\n

La plupart des mutations ge\u0301ne\u0301tiques observe\u0301es chez les enfants proviennent du pe\u0300re<\/b><\/p>\n

L\u2019e\u0301tude re\u0301ve\u0300le e\u0301galement que ces mutations ponctuelles se retrouvent plus souvent dans une quarantaine de ge\u0300nes et qu\u2019elles favoriseraient le de\u0301veloppement des cellules produisant les spermatozoi\u0308des. Les types de mutations ge\u0301ne\u0301tiques associe\u0301es a\u0300 la consommation d\u2019alcool ou de tabac retrouve\u0301es dans les cellules du sang n\u2019e\u0301taient pas pre\u0301sentes dans l\u2019ADN des spermatozoi\u0308des, ce qui montre que ces derniers sont plus prote\u0301ge\u0301s des agents mutage\u0300nes exte\u0301rieurs que les autres cellules de l\u2019organisme.<\/p>\n

La plupart des mutations ge\u0301ne\u0301tiques observe\u0301es chez les enfants proviennent du pe\u0300re et le risque de leur apparition est de\u0301ja\u0300 pris en compte en France par le fait que l\u2019a\u0302ge limite pour le don de sperme est de 44 ans. Chez la femme, la production de son stock d\u2019ovocytes s\u2019arre\u0302te avant la naissance et leur nombre plus limite\u0301 re\u0301duit le risque d\u2019apparition de mutations, les anomalies transmises se situant surtout au niveau chromosomique.<\/p>\n

Pour plus d’informations et d’analyses sur la Senegal<\/span>, suivez Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Senegal. Chaque jour, environ 200 millions de spermatozoi\u0308des sont produits par les testicules chez l\u2019homme et cette intense prolife\u0301ration cellulaire les expose a\u0300 des erreurs de copie de leur ADN causant des mutations. Une premie\u0300re e\u0301tude de la se\u0301quence de l\u2019ADN des spermatozoi\u0308des effectue\u0301e par des chercheurs du Wellcome Sanger Institute au Royaume-Uni, […]<\/p>\n","protected":false},"author":82,"featured_media":72931,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-72932","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"\nAugmentation des Mutations D\u00e9l\u00e9t\u00e8res des Spermatozo\u00efdes - Senegal<\/title>\n<meta name=\"description\" content=\"Chaque jour, environ 200 millions de spermatozoi\u0308des sont produits par les testicules chez l\u2019homme et cette intense prol ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Augmentation des Mutations D\u00e9l\u00e9t\u00e8res des Spermatozo\u00efdes\" \/>\n<meta property=\"og:description\" content=\"Chaque jour, environ 200 millions de spermatozoi\u0308des sont produits par les testicules chez l\u2019homme et cette intense prol ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\" \/>\n<meta property=\"og:site_name\" content=\"Senegal\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-25T12:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-26T04:25:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/11\/sm_1764159893.498223.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Augmentation des Mutations D\u00e9l\u00e9t\u00e8res des Spermatozo\u00efdes\",\"datePublished\":\"2025-11-25T12:00:00+00:00\",\"dateModified\":\"2025-11-26T04:25:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\"},\"wordCount\":490,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/11\/sm_1764159893.498223.jpg\",\"keywords\":[\"Senegal\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\",\"url\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/augmentation-des-mutations-deleteres-des-spermatozoides\",\"name\":\"Augmentation des Mutations D\u00e9l\u00e9t\u00e8res des Spermatozo\u00efdes - 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