{"id":73387,"date":"2025-12-12T12:00:00","date_gmt":"2025-12-12T12:00:00","guid":{"rendered":"https:\/\/www.africa-press.net\/senegal\/politique\/ebola-et-les-organoides-dans-le-systeme-digestif"},"modified":"2025-12-12T21:34:21","modified_gmt":"2025-12-12T21:34:21","slug":"ebola-et-les-organoides-dans-le-systeme-digestif","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif","title":{"rendered":"Ebola et les Organo\u00efdes dans le Syst\u00e8me Digestif"},"content":{"rendered":"<p><span style=\"color: #ff6600\"><strong>Africa-Press &#8211; Senegal. <\/strong><\/span>Les virus d\u2019Ebola et de Marburg font partie des pathoge\u0300nes les plus le\u0301taux qui soient avec des taux de mortalite\u0301 pouvant atteindre 90%. Tous deux membres de la famille des filovirus, ils ont cause\u0301 des e\u0301pide\u0301mies de\u0301vastatrices depuis les anne\u0301es 70 essentiellement en Afrique. Les tableaux cliniques des deux maladies sont identiques, Ebola e\u0301tant plus grave et plus mortel. Se signalant par de fortes ce\u0301phale\u0301es, des fie\u0300vres aigu\u0308es, des diarrhe\u0301es, des vomissements et une intense de\u0301shydratation de\u0300s les premiers jours d\u2019incubation, les deux infections de\u0301ge\u0301ne\u0300rent souvent en des manifestations he\u0301morragiques multiples entrainant la mort du patient une dizaine de jours apre\u0300s l\u2019apparition des premiers sympto\u0302mes.<\/p>\n<p>Aucun vaccin ni traitement n\u2019existe contre ces virus. Il apparai\u0302t donc essentiel de concevoir de nouvelles strate\u0301gies de lutte. C\u2019est dans ce cadre qu\u2019interviennent les travaux mene\u0301s par Elizabeth Flores du centre me\u0301dical de Boston (EU) et ses colle\u0300gues.<\/p>\n<p><b>Des mini intestins et colons<\/b><\/p>\n<p>L\u2019e\u0301quipe a conc\u0327u des organoi\u0308des, mini re\u0301pliques 3D de l\u2019intestin humain et de l\u2019e\u0301pithe\u0301lium colique. Cultive\u0301s a\u0300 partir de cellules souches pluripotentes induites (CSPi) cre\u0301e\u0301s en laboratoire a\u0300 partir de cellules de peau ou de globules rouges adultes, ces organoi\u0308des ont ensuite e\u0301te\u0301 infecte\u0301s avec les virus Ebola et Marburg. Le but de l\u2019expe\u0301rience e\u0301tant de voir comment les deux virus interagissent avec les tissus intestinaux et peuvent perturber la se\u0301cre\u0301tion des fluides corporels.<\/p>\n<p>En analysant les activite\u0301s ge\u0301ne\u0301tiques des organoi\u0308des infecte\u0301s, les chercheurs ont notamment note\u0301 que leurs intestin et co\u0302lon miniatures se comportaient diffe\u0301remment face aux virus, le second e\u0301tant plus se\u0301ve\u0300rement impacte\u0301.<\/p>\n<p><b>Une barrie\u0300re intestinale totalement poreuse<\/b><\/p>\n<p>Les deux virus agissent en perturbant les voies de signalisation implique\u0301es dans le transport des fluides et des ions le long de l\u2019appareil digestif. De fait, ils endommagent la muqueuse intestinale, a\u0300 la fois la surface externe des cellules ainsi que les jonctions entre cellules, les deux e\u0301le\u0301ments essentiels pour contro\u0302ler tout ce qui est autorise\u0301 a\u0300 traverser la barrie\u0300re intestinale. Ce qui explique que les organes digestifs deviennent poreux, entrainant biento\u0302t une de\u0301tresse ge\u0301ne\u0301ralise\u0301e de tout l\u2019organisme du malade. Dans le me\u0302me temps, les chercheurs ame\u0301ricains ont montre\u0301 que la re\u0301ponse immunitaire e\u0301tait totalement affaiblie et retarde\u0301e, tout spe\u0301cialement la production des interfe\u0301rons, des prote\u0301ines qui normalement combattent les virus et les empe\u0302chent de se multiplier.<\/p>\n<p>Avec ces travaux, les scientifiques ont ainsi permis de mieux appre\u0301hender les strate\u0301gies destructrices d\u2019Ebola et de Marburg, mais e\u0301galement de de\u0301montrer tout le potentiel de ces mini-organes de laboratoire que sont les organoi\u0308des. Ouvrant la voie a\u0300 la mise au point de the\u0301rapies cible\u0301es spe\u0301cifiquement contre ces deux impitoyables pathoge\u0300nes.<\/p>\n<p><strong>Pour plus d&rsquo;informations et d&rsquo;analyses sur la <span style=\"color: #ff6600\">Senegal<\/span>, suivez <span style=\"color: #ff6600\">Africa-Press<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Africa-Press &#8211; Senegal. Les virus d\u2019Ebola et de Marburg font partie des pathoge\u0300nes les plus le\u0301taux qui soient avec des taux de mortalite\u0301 pouvant atteindre 90%. Tous deux membres de la famille des filovirus, ils ont cause\u0301 des e\u0301pide\u0301mies de\u0301vastatrices depuis les anne\u0301es 70 essentiellement en Afrique. Les tableaux cliniques des deux maladies sont identiques, [&hellip;]<\/p>\n","protected":false},"author":82,"featured_media":73386,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[44],"class_list":["post-73387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-senegal-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ebola et les Organo\u00efdes dans le Syst\u00e8me Digestif - Senegal<\/title>\n<meta name=\"description\" content=\"Les virus d\u2019Ebola et de Marburg font partie des pathoge\u0300nes les plus le\u0301taux qui soient avec des taux de mortalite\u0301 pouv ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ebola et les Organo\u00efdes dans le Syst\u00e8me Digestif\" \/>\n<meta property=\"og:description\" content=\"Les virus d\u2019Ebola et de Marburg font partie des pathoge\u0300nes les plus le\u0301taux qui soient avec des taux de mortalite\u0301 pouv ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\" \/>\n<meta property=\"og:site_name\" content=\"Senegal\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-12T12:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-12T21:34:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/12\/sm_1765601149.38735.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Ebola et les Organo\u00efdes dans le Syst\u00e8me Digestif\",\"datePublished\":\"2025-12-12T12:00:00+00:00\",\"dateModified\":\"2025-12-12T21:34:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\"},\"wordCount\":543,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/senegal\/sites\/13\/2025\/12\/sm_1765601149.38735.jpg\",\"keywords\":[\"Senegal\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\",\"url\":\"https:\/\/www.africa-press.net\/senegal\/toutes-les-actualites\/ebola-et-les-organoides-dans-le-systeme-digestif\",\"name\":\"Ebola et les Organo\u00efdes dans le Syst\u00e8me Digestif - 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