{"id":35173,"date":"2021-08-18T16:20:31","date_gmt":"2021-08-18T16:20:31","guid":{"rendered":"https:\/\/www.africa-press.net\/tanzania\/?p=35173"},"modified":"2021-08-18T14:19:43","modified_gmt":"2021-08-18T14:19:43","slug":"hiv-vaccine-trials-ready-to-start","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/tanzania\/all-news\/hiv-vaccine-trials-ready-to-start","title":{"rendered":"HIV vaccine trials ready to start"},"content":{"rendered":"

Africa-Press<\/a> – Tanzania<\/a>. <\/strong><\/span>Dar es Salaam\/ Massachusetts.<\/b><\/p>\n

Biotechnology company Moderna is preparing to begin human trials on HIV vaccines today (Wednesday) in a landmark development that brings hope to the world.<\/p>\n

The Massachusetts-based firm said in a statement yesterday that it will begin human trials on HIV vaccines using the same mRNA platform as the firm\u2019s Covid-19 vaccine.<\/p>\n

The development sends hope to medical practitioners, with Dr Elisha Osati describing it as a \u201clandmark development\u201d.<\/p>\n

\u201cIt is a landmark development because such trials have been conducted, including in Tanzania where they (trials) were conducted twice though little was achieved,\u201d he said.<\/p>\n

He said if the trials finally bring positive results, then the success would be a game changer because the world will now be directing their resources to other pressing needs.<\/p>\n

\u201cWe remain positive that it might bring the intended results and the world is expecting the results with keen interest so that when a vaccine is finally obtained, the world will direct its resources to other pressing economic, healthy and social needs,\u201d he said.<\/p>\n

A programme manager with the Elizabeth Glaser Pediatric Aids Foundation (Egpaf), Mr Juma Songoro, said under normal circumstances, vaccination was better than treatment. He, however, said there had been a number of vaccine trials during the past few years but little was achieved.<\/p>\n

Moderna\u2019s entry posted to the National Institutes of Health\u2019s registry of clinical trials shows that the trials are estimated to start on August 19 (tomorrow) and should be completed by around May, 2023.<\/p>\n

Moderna has two HIV vaccine candidates, mRNA-1644 and mRNA-1644v2-Core, both of which have cleared initial safety testing before being used on humans for the first time. The randomized trials will include 56 HIV-negative participants aged 18 to 56.<\/p>\n

HIV is one of several viruses that Moderna is targeting for vaccine development using the mRNA platform. The Moderna and the Pfizer\/BioNTech Covid-19 vaccines were the first-ever mRNA vaccines authorized for human use in the US, although the technology had been in development for decades and was reaching maturity as the pandemic emerged.<\/p>\n

Attempts to develop an HIV vaccine have been ongoing for decades but have met with little success. While multiple vaccine candidates have reached the trial stage, not all were found to be safe and almost none were shown to be even modestly effective.<\/p>\n

What was likely the most effective candidate, a vaccine trialed in Thailand during the 2000s, was found to reduce infections by around 30 percent, although the trial results were considered controversial by some scientists.<\/p>\n

Scientists were forced to call off the trial of a different vaccine candidate during the same decade when it was found that the vaccine may have actually increased the risk of catching HIV rather than preventing infections.<\/p>\n

Unlike the Moderna candidate, none of the previous HIV vaccine candidates were developed using mRNA. Since the mRNA platform offers a fresh approach and has been shown to be safe and effective with Covid-19, scientists are hopeful that it will lead to an HIV breakthrough.<\/p>\n

In addition, mRNA technology could have some distinct advantages over more traditional methods due to the nature of HIV\u2014a virus that has quickly mutated into many different variants over the decades.<\/p>\n

\u201cThe mRNA platform makes it easy to develop vaccines against variants because it just requires an update to the coding sequences in the mRNA that code for the variant,\u201d Dr Rajesh Gandhi, an infectious disease expert who chairs the HIV Medicine Association, told Verywell Health.<\/p>\n

\u201cBased on its success in protecting against Covid-19, I am hopeful that mRNA technology will revolutionize our ability to develop vaccines against other pathogens, like HIV and influenza,\u201d added Dr Gandhi. Several other companies are also working on HIV vaccines.<\/p>\n

Some candidates are currently in, or about to enter, clinical trials. The other vaccines were developed using a variety of approaches, including the technique used in the partially-successful Thailand trial.<\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Tanzania. Dar es Salaam\/ Massachusetts. Biotechnology company Moderna is preparing to begin human trials on HIV vaccines today (Wednesday) in a landmark development that brings hope to the world. The Massachusetts-based firm said in a statement yesterday that it will begin human trials on HIV vaccines using the same mRNA platform as the […]<\/p>\n","protected":false},"author":84,"featured_media":35172,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,3,8,16],"tags":[6990,6991,711],"class_list":["post-35173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news","category-community","category-homepage-english","category-twitter","tag-africa-press-2","tag-africa-press-tanzania","tag-tanzania"],"yoast_head":"\nHIV vaccine trials ready to start - Tanzania<\/title>\n<meta name=\"description\" content=\"Dar es Salaam\/ Massachusetts. 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