{"id":66255,"date":"2024-06-08T18:16:27","date_gmt":"2024-06-08T18:16:27","guid":{"rendered":"https:\/\/www.africa-press.net\/tchad\/politique\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome"},"modified":"2024-06-08T19:33:19","modified_gmt":"2024-06-08T19:33:19","slug":"un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome","title":{"rendered":"Un virus courant est \u00e0 l’origine d’un grave cancer du cerveau, le glioblastome"},"content":{"rendered":"

Africa-Press – Tchad. <\/strong><\/span>Le glioblastome, cancer du cerveau le plus fre\u0301quent et de plus mauvais pronostic, est du\u0302 a\u0300 un virus courant, le cytome\u0301galovirus (ou CMV), re\u0301ve\u0300le une longue enque\u0302te mene\u0301e par le virologue me\u0301dical Georges Herbein et son e\u0301quipe au CHU de Besanc\u0327on et a\u0300 l\u2019Universite\u0301 de Franche-Comte\u0301. Ces travaux ont e\u0301te\u0301 publie\u0301s dans la revue Cancer Gene Therapy.<\/p>\n

La piste du CMV, ancienne mais pas de\u0301montre\u0301e jusqu’a\u0300 pre\u0301sent<\/b><\/p>\n

\u00ab\u00a0La piste n’est pas nouvelle, elle a e\u0301merge\u0301 il y a une vingtaine d’anne\u0301es quand du CMV a e\u0301te\u0301 identifie\u0301 dans la majorite\u0301 des glioblastomes bien qu’en tre\u0300s faible quantite\u0301\u00a0\u00bb, pre\u0301cise le spe\u0301cialiste de la maladie Franc\u0327ois Ducray au service de neuro-oncologie des Hospices Civils de Lyon.<\/p>\n

Pour de\u0301montrer le ro\u0302le causal du virus, les chercheurs ont isole\u0301 le virus de biopsies de la tumeur lors de son ope\u0301ration chez trois patients et montre\u0301 qu\u2019il e\u0301tait capable de transformer en quelques mois in vitro des cellules du cerveau humain en cellules cance\u0301reuses typiques de la maladie. Une fois transfe\u0301re\u0301es dans le cerveau de souris, ces cellules ont bien donne\u0301 un glioblastome mortel.<\/p>\n

Pourquoi ce virus courant devient-il cance\u0301rige\u0300ne chez certains ?<\/b><\/p>\n

Point crucial, l\u2019e\u0301volution plus ou moins rapide de la maladie chez les animaux a refle\u0301te\u0301 celle qui avait e\u0301te\u0301 observe\u0301e chez les patients porteurs de CMV diffe\u0301rents, preuve que le virus joue un ro\u0302le de\u0301terminant.<\/p>\n

Pourquoi le CMV qui infecte pre\u0300s de la moitie\u0301 de la population franc\u0327aise devient-il cance\u0301rige\u0300ne chez certaines personnes ? \u00ab\u00a0Nous ne le savons pas encore mais des mutations pourraient intervenir\u00a0\u00bb, pre\u0301cise Georges Herbein.<\/p>\n

\u00ab\u00a0Ce virus s\u2019installe a\u0300 vie dans l\u2019organisme\u00a0\u00bb<\/b><\/p>\n

L\u2019infection se fait durant la prime enfance par des gouttelettes de salive et ne pre\u0301sente le plus souvent aucun sympto\u0302me. \u00ab\u00a0Comme les autres herpe\u0300s virus, le CMV s\u2019installe a\u0300 vie dans l\u2019organisme et se re\u0301active par pousse\u0301es occasionnelles\u00a0\u00bb, ajoute le chercheur. Cette de\u0301couverte offre des pistes de traitement contre ce cancer du cerveau actuellement incurable.<\/p>\n

\u00ab\u00a0Des essais cliniques sont de\u0301ja\u0300 en cours pour voir si l\u2019utilisation d\u2019un antiviral, le ganciclovir, pourrait ralentir la progression de la maladie mais il n\u2019est pas su\u0302r que le virus soit ne\u0301cessaire a\u0300 la progression du cancer par la suite\u00a0\u00bb, note Franc\u0327ois Ducray.<\/p>\n

Une solution a\u0300 plus long terme serait un vaccin contre le CMV. \u00ab\u00a0Il n\u2019existe pas encore mais nous y travaillons\u00a0\u00bb, ajoute Georges Herbein. Un tel vaccin chez le jeune enfant permettrait, comme dans le cas du papillomavirus et des cancers du col de l\u2019ute\u0301rus et oropharynge\u0301, d\u2019e\u0301viter un cancer redoutable des de\u0301cennies plus tard.<\/p>\n

Pour plus d’informations et d’analyses sur la Tchad<\/a>, suivez Africa-Press<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Tchad. Le glioblastome, cancer du cerveau le plus fre\u0301quent et de plus mauvais pronostic, est du\u0302 a\u0300 un virus courant, le cytome\u0301galovirus (ou CMV), re\u0301ve\u0300le une longue enque\u0302te mene\u0301e par le virologue me\u0301dical Georges Herbein et son e\u0301quipe au CHU de Besanc\u0327on et a\u0300 l\u2019Universite\u0301 de Franche-Comte\u0301. Ces travaux ont e\u0301te\u0301 publie\u0301s dans […]<\/p>\n","protected":false},"author":82,"featured_media":66254,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,10],"tags":[37,292,29],"class_list":["post-66255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divers","category-toutes-les-actualites","tag-africa-press","tag-africa-press-tchad","tag-tchad"],"yoast_head":"\nUn virus courant est \u00e0 l'origine d'un grave cancer du cerveau, le glioblastome - tchad<\/title>\n<meta name=\"description\" content=\"Le glioblastome, cancer du cerveau le plus fre\u0301quent et de plus mauvais pronostic, est du\u0302 a\u0300 un virus courant, le cytom ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un virus courant est \u00e0 l'origine d'un grave cancer du cerveau, le glioblastome\" \/>\n<meta property=\"og:description\" content=\"Le glioblastome, cancer du cerveau le plus fre\u0301quent et de plus mauvais pronostic, est du\u0302 a\u0300 un virus courant, le cytom ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\" \/>\n<meta property=\"og:site_name\" content=\"tchad\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-08T18:16:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-08T19:33:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/tchad\/sites\/41\/2024\/06\/sm_1717862467.189384.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"899\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditorfr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditorfr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\"},\"author\":{\"name\":\"cfeditorfr\",\"@id\":\"https:\/\/www.africa-press.net\/tchad\/#\/schema\/person\/2b1cf3cd81a31e3cd26889ca66d677f1\"},\"headline\":\"Un virus courant est \u00e0 l’origine d’un grave cancer du cerveau, le glioblastome\",\"datePublished\":\"2024-06-08T18:16:27+00:00\",\"dateModified\":\"2024-06-08T19:33:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\"},\"wordCount\":515,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome#primaryimage\"},\"thumbnailUrl\":\"https:\/\/static.africa-press.net\/tchad\/sites\/41\/2024\/06\/sm_1717862467.189384.jpg\",\"keywords\":[\"Africa Press\",\"Africa Press-Tchad\",\"Tchad\"],\"articleSection\":[\"Divers\",\"Toutes les actualit\u00e9s\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\",\"url\":\"https:\/\/www.africa-press.net\/tchad\/toutes-les-actualites\/un-virus-courant-est-a-lorigine-dun-grave-cancer-du-cerveau-le-glioblastome\",\"name\":\"Un virus courant est \u00e0 l'origine d'un grave cancer du cerveau, le glioblastome - 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