{"id":47849,"date":"2021-10-07T20:15:37","date_gmt":"2021-10-07T18:15:37","guid":{"rendered":"https:\/\/www.africa-press.net\/zimbabwe\/?p=47849"},"modified":"2021-10-07T19:22:48","modified_gmt":"2021-10-07T17:22:48","slug":"ivermectin-how-false-science-created-a-covid-miracle-drug","status":"publish","type":"post","link":"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/ivermectin-how-false-science-created-a-covid-miracle-drug","title":{"rendered":"Ivermectin: How False Science Created A\u00a0Covid \u2018Miracle\u2019 Drug"},"content":{"rendered":"

Africa-Press<\/a> – Zimbabwe<\/a>. <\/strong><\/span>BBC<\/b> – IVERMECTIN has been called a Covid \u201cmiracle\u201d drug, championed by vaccine opponents, and recommended by health authorities in some countries.<\/p>\n

But the BBC can reveal there are serious errors in a number of key studies that the drug\u2019s promoters rely on.<\/p>\n

For some years ivermectin has been a vital anti-parasitic medicine used to treat humans and animals.<\/p>\n

But during the pandemic there has been a clamour from some proponents for using the drug for something else \u2013 to fight Covid and prevent deaths.<\/p>\n

The health authorities in the US, UK and EU have found there is insufficient evidence for using the drug against Covid, but thousands of supporters, many of them anti-vaccine activists, have continued to vigorously campaign for its use.<\/p>\n

Members of social media groups swap tips on getting hold of the drug, even advocating the versions used for animals.<\/p>\n

The hype around ivermectin \u2013 based on the strength of belief in the research \u2013 has driven large numbers of people around the world to use it.<\/p>\n

Campaigners for the drug point to a number of scientific studies and often claim this evidence is being ignored or covered up. But a review by a group of independent scientists has cast serious doubt on that body of research.<\/p>\n

The BBC can reveal that more than a third of 26 major trials of the drug for use on Covid have serious errors or signs of potential fraud. None of the rest show convincing evidence of ivermectin\u2019s effectiveness.<\/p>\n

Dr Kyle Sheldrick, one of the group investigating the studies, said they had not found \u201ca single clinical trial\u201d claiming to show that ivermectin prevented Covid deaths that did not contain \u201ceither obvious signs of fabrication or errors so critical they invalidate the study\u201d.<\/p>\n

Major problems included:<\/p>\n

The scientists in the group \u2013 Dr Gideon Meyerowitz-Katz, Dr James Heathers, Dr Nick Brown and Dr Sheldrick \u2013 each have a track record of exposing dodgy science.<\/p>\n

They\u2019ve been working together remotely on an informal and voluntary basis during the pandemic.<\/p>\n

They formed a group looking deeper into ivermectin studies after biomedical student Jack Lawrence spotted problems with an influential study from Egypt. Among other issues, it contained patients who turned out to have died before the trial started. It has now been retracted by the journal that published it.<\/p>\n

The group of independent scientists examined virtually every randomised controlled trial (RCT) on ivermectin and Covid \u2013 in theory the highest quality evidence \u2013 including all the key studies regularly cited by the drug\u2019s promoters.<\/p>\n

RCTs involve people being randomly chosen to receive either the drug which is being tested or a placebo \u2013 a dummy drug with no active properties.<\/p>\n

The team also looked at six particularly influential observational trials.<\/p>\n

This type of trial looks at what happens to people who are taking the drug anyway, so can be biased by the types of people who choose to take the treatment.<\/p>\n

Out of a total of 26 studies examined, there was evidence in five that the data may have been faked \u2013 for example they contained virtually impossible numbers or rows of identical patients copied and pasted.<\/p>\n

In a further five there were major red flags \u2013 for example, numbers didn\u2019t add up, percentages were calculated incorrectly or local health bodies weren\u2019t aware they had taken place.<\/p>\n

On top of these flawed trials, there were 14 authors of studies who failed to send data back. The independent scientists have flagged this as a possible indicator of fraud.<\/p>\n

The sample of research papers examined by the independent group also contains some high-quality studies from around the world.<\/p>\n

But the major problems were all in the studies making big claims for ivermectin \u2013 in fact, the bigger the claim in terms of lives saved or infections prevented, the greater the concerns suggesting it might be faked or invalid, the researchers discovered.<\/p>\n

While it\u2019s extremely difficult to rule out human error in these trials, Dr Sheldrick, a medical doctor and researcher at the University of New South Wales in Sydney, believes it is highly likely at least some of them may have been knowingly manipulated.<\/p>\n

A recent study in Lebanon was found to have blocks of details of 11 patients that had been copied and pasted repeatedly \u2013 suggesting many of the trial\u2019s apparent patients didn\u2019t really exist.<\/p>\n

The study\u2019s authors told the BBC that the \u201coriginal set of data was rigged, sabotaged or mistakenly entered in the final file\u201d and that they have submitted a retraction to the scientific journal which published it.<\/p>\n

Another study from Iran seemed to show that ivermectin prevented people dying from Covid.<\/p>\n

But the scientists who investigated it found issues. The records of how much iron was in patients\u2019 blood contained numbers in a sequence that was unlikely to come up naturally.<\/p>\n

And the patients given the placebo turned out to have had much lower levels of oxygen in their blood before the trial started than those given ivermectin. So they were already sicker and statistically more likely to die.<\/p>\n

But this pattern was repeated across a wide range of different measurements. The people with \u201cbad\u201d measurements ended up in the placebo group, the ones with \u201cgood\u201d measurements in the ivermectin group.<\/p>\n

The likelihood of this happening randomly across all these different measurements was vanishingly small, Dr Sheldrick said.<\/p>\n

Dr Morteza Niaee, who led the Iran study, defended the results and the methodology and disagreed with problems pointed out to him, adding that it was \u201cvery normal to see such randomisation\u201d when lots of different factors were considered and not all of them had any bearing on participants\u2019 Covid risk.<\/p>\n

But the Lebanon and Iran trials were excluded from a paper for Cochrane \u2013 the international experts in reviewing scientific evidence \u2013 because they were \u201csuch poorly reported studies\u201d.<\/p>\n

The review concluded there was no evidence of benefit for ivermectin when it comes to Covid.<\/p>\n

The largest and highest quality ivermectin study published so far is the Together trial at the McMaster University in Canada. It found no benefit for the drug when it comes to Covid.<\/p>\n

Ivermectin is generally considered a safe drug, though there have been some reports of side effects.<\/p>\n

Calls over suspected ivermectin poisoning in the US have increased a lot but from a very small base (435 to 1,143 this year) and most of these cases were not serious.<\/p>\n

Patients have had vomiting, diarrhoea, hallucinations, confusion, drowsiness and tremors.<\/p>\n

But indirect harm can come from giving people a false sense of security, especially if they choose ivermectin instead of seeking hospital treatment for Covid, or getting vaccinated in the first place.<\/p>\n

Dr Patricia Garcia, a public health expert in Peru, said at one stage she estimated that 14 out of every 15 patients she saw in hospital had been taking ivermectin and by the time they came in they were \u201creally, really sick\u201d.<\/p>\n

Large pro-ivermectin Facebook groups have turned into forums for people to find advice on where to buy it, including preparations meant for animals.<\/p>\n

Some groups regularly contain posts about conspiracy theories of ivermectin cover-ups, as well as pushing anti-vaccine sentiment or encouraging patients to leave hospital if they aren\u2019t getting the drug.<\/p>\n

The groups often provide a gateway to more fringe communities on the encrypted app Telegram.<\/p>\n

These channels have co-ordinated harassment of doctors who fail to prescribe ivermectin and abuse has been aimed at scientists. Prof Andrew Hill, from the University of Liverpool, wrote an influential positive review of ivermectin, originally saying the world should \u201cget prepared, get supplies, get ready to approve [the drug]\u201d.<\/p>\n

Now he says the studies don\u2019t stand up to scrutiny \u2013 but after he changed his view, based on new evidence emerging, he received vicious abuse.<\/p>\n

A small number of qualified doctors have had an exaggerated influence on the ivermectin debate. Noted proponent Dr Pierre Kory\u2019s views have not changed despite the major questions over the trials. He criticised \u201csuperficial interpretations of emerging trials data\u201d.<\/p>\n

Dr Tess Lawrie \u2013 a medical doctor who specialises in pregnancy and childbirth \u2013 founded the British Ivermectin Recommendation Development (Bird) Group.<\/p>\n

She has called for a pause to the Covid-19 vaccination programme and has made unsubstantiated claims implying the Covid vaccine had led to a large number of deaths based on a common misreading of safety data.<\/p>\n

When asked during an online panel what evidence might persuade her ivermectin didn\u2019t work she replied: \u201cIvermectin works. There\u2019s nothing that will persuade me.\u201d<\/p>\n

She told the BBC: \u201cThe only issues with the evidence base are the relentless efforts to undermine it.\u201d<\/p>\n

Around the world, it was originally not opposition to vaccines but a lack of them that led people to ivermectin.<\/p>\n

The drug has at various points been approved, recommended or prescribed for Covid in India, South Africa, Peru and much of the rest of Latin America, as well as in Slovakia.<\/p>\n

Health authorities in Peru and India have stopped recommending ivermectin in treatment guidelines.<\/p>\n

In February, Merck \u2013 one of the companies that makes the drug \u2013 said there was \u201cno scientific basis for a potential therapeutic effect against Covid-19\u201d.<\/p>\n

In South Africa, the drug has become a battleground \u2013 doctors point out the lack of evidence but many patients desperately want access as the vaccine rollout has been patchy and problematic.<\/p>\n

One GP in the country described a relative, a registered nurse, who didn\u2019t book a coronavirus vaccine she was eligible for and then caught the virus.<\/p>\n

\u201cWhen she started getting worse, instead of getting proper assessment and treatment, she treated herself with ivermectin,\u201d she said.<\/p>\n

\u201cInstead of consulting a doctor, she continued with the ivermectin and got home oxygen. By the time I heard how low her oxygen saturation levels were (66%), I begged her daughter to take her to casualty.<\/p>\n

\u201cAt first they were reluctant, but I convinced them to go. She passed away a few hours later.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Africa-Press – Zimbabwe. BBC – IVERMECTIN has been called a Covid \u201cmiracle\u201d drug, championed by vaccine opponents, and recommended by health authorities in some countries. But the BBC can reveal there are serious errors in a number of key studies that the drug\u2019s promoters rely on. For some years ivermectin has been a vital anti-parasitic […]<\/p>\n","protected":false},"author":84,"featured_media":47848,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4,35,15],"tags":[1493,2189,19],"class_list":["post-47849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news","category-community","category-homepage-english","category-twitter","tag-africa-press","tag-africa-press-zimbabwe-2","tag-zimbabwe"],"yoast_head":"\nIvermectin: How False Science Created A\u00a0Covid \u2018Miracle\u2019 Drug - zimbabwe<\/title>\n<meta name=\"description\" content=\"BBC - IVERMECTIN has been called a Covid \u201cmiracle\u201d drug, championed by vaccine opponents, and recommended by heal ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/ivermectin-how-false-science-created-a-covid-miracle-drug\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ivermectin: How False Science Created A\u00a0Covid \u2018Miracle\u2019 Drug\" \/>\n<meta property=\"og:description\" content=\"BBC - 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