Africa-Press – Lesotho. Bertozzi, from Stanford University, Morten Meldal, from the University of Copenhagen, and K. Barry Sharpless, from the Scripps Research Institute, won the 2022 Nobel Prize in Chemistry, for “the development of click chemistry and bioorthogonal”.
K. Barry Sharpless thus becomes the fifth person to receive two Nobel Prizes. He had already received the Nobel Prize in Chemistry in 2001 and is now following in the footsteps of John Bardeen, Marie Skłodowska Curie, Linus Pauling and Frederick Sanger.
Johan Aqvist, chairman of the Nobel Chemistry Committee, said this year’s prize “is about not overcomplicating things, but working with what is easy and simple.
” “Functional molecules can be built even following a direct route,” he said.
Click chemistry is a class of biocompatible small molecule reactions commonly used in bioconjugation, allowing the coupling of substrates of choice with specific biomolecules.
Bioorthogonal, a term coined by Bertozzi herself, is a chemical reaction that can occur within living systems without interfering with native biochemical processes.
Barry Sharpless coined the concept of click chemistry around 2000, “which is a simple and reliable form of chemistry where reactions occur quickly and unwanted by-products are avoided,” the Swedish Academy explained in a statement.
Shortly afterwards, Morten Meldal and Barry Sharpless – independently – “presented what is today the crown jewel of click chemistry: the copper-catalyzed azide-alkyne cycloaddition.
This is an elegant and efficient chemical reaction” that is now used in a generalized way. “Among many other uses, it is used in the development of pharmaceuticals, for mapping DNA and creating more fit-for-purpose materials.
” Carolyn Bertozzi “has taken click chemistry to a new level. To map important but elusive biomolecules on the surface of cells – glycans – she developed click reactions that work inside living organisms.
Its bioorthogonal reactions occur without interrupting the normal chemistry of the cell. cell”. These reactions are “used globally to explore cells and trace biological processes.
Using bioorthogonal reactions, researchers have improved the targeting of cancer drugs, which are now being tested in clinical trials. ” In reaction, Carolyn R.
Bertozzi highlighted the importance of click chemistry in Medicine and in “drug administration”, implying doing “chemistry inside living patients to ensure that the drugs get to the right place and not the wrong one”.
In a call with the Committee, she said she was “absolutely stunned” by the award. “I’m still not completely sure it’s real,” she admitted, who is the eighth woman scientist to receive the Nobel Prize in Chemistry.
The award was announced yesterday in Stockholm, Sweden. The 2022 season of the announcement of the Nobel prizes began on Monday, with the one for Medicine, and ends on 7 October with the one for Peace, a much-awaited category this year, in time of war in Europe.
In between, the prizes for Physics (4 October) and Chemistry (5 yesterday) were awarded, today it will be the turn of the Nobel Prize for Literature. The winners receive a diploma, a gold medal and an amount of money, which this year will be 10 million Swedish crowns (about 919 thousand euros) to be divided between the various categories.
Profile of the distinguished Barry Sharpless – Born in 1941 in Philadelphia, Pennsylvania, Barry Sharpless attended a Quaker religious school from grades 6 to 12.
Twice a week, all the students attended the Quaker Meeting, prayer meetings that consisted of silent meditation, except when someone was called upon to speak.
In an autobiographical article, the American reported that he was never invited to speak, but that didn’t mean he didn’t have many thoughts on his mind.
He was a fishing and boating aficionado. Carolyn Ruth Bertozzi – Is an American biochemist. A member of the National Academy of Inventors, she was born October 10, 1966, in Boston, Massachusetts, USA
Stanford University Chemistry Professor Carolyn Ruth Bertozzi has developed a set of reactions that work quickly and efficiently, even in a messy cellular environment.
She named the field of bioorthogonal chemistry, which revolutionized biological research, medical imaging, and drug administration. “Orthogonal means not interacting and bioorthogonal means not interacting with biology,” says Bertozzi.
Morten P. Meldal – Born January 16, 1954 in Denmark. Professor of Chemistry at the University of Copenhagen, he is best known for developing the CuAAC click reaction, concurrent with but independent of Valery V. Fokin and K. Barry Sharpless. In 1981 he graduated with MSc. in Chemical Engineering from the Technical University of Denmark. Morten P.
Meldal obtained his doctorate in 1983 at the Institute of Organic Chemistry of the Technical University of Denmark, in “Synthesis and conformational analysis of O-specific antigens associated with Salmonella serogroups A, B and D1.
For More News And Analysis About Lesotho Follow Africa-Press
